BENZIMIDAZOLES, THEIR 1-, 3,-ISOMERIC COMPOSITIONS AND THEIR SALTS AS WELL AS THE PROCESS FOR THEIR PREPARATION
Opisani su benzimidazoli, formule u kojoj označavaju R1, fluor, hlor ili brom, alkil, cikloalkil, fluormetil, difluormetil ili trifluormetil grupu; R2, u datom slučaju, sa jednom ili dve alkil grupe ili sa tetrametilen ili pentametilen grupom supstituisanu 5-, 6-ili 7-članu alkilenimino ili alkenile...
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| creator | HAUEL, NORBERT DR VAN MEEL, JACQUES DR RIES, UWE DR WIENEN, WOLFGANG DR ENTZEROTH, MICHAEL DR NARR, BERTHOLD DR |
| description | Opisani su benzimidazoli, formule u kojoj označavaju R1, fluor, hlor ili brom, alkil, cikloalkil, fluormetil, difluormetil ili trifluormetil grupu; R2, u datom slučaju, sa jednom ili dve alkil grupe ili sa tetrametilen ili pentametilen grupom supstituisanu 5-, 6-ili 7-članu alkilenimino ili alkenilenimino grupu, sa alkil ili fenil grupom mono ili disupstituisanu imido grupu maleinske kiseline, u 1-položaju, sa alkil grupom, sa 1 do 6 atoma ugljenika, ili sa cikloalkil grupom supstituisanu benzimidazol-2-il ili 4,5,6,7-tetrahidro-benzimidazol-2-il grupu, imidazo(2,1-b)tiazol-6-il, imidazo(1,2-a)piridin-2-il, 5,6,7,8-tetrahidro-imidazo-(1,2-a)-piridin-2-il, imidazo(1,2-a)pirimidin-2-il, imidazo(4,5-b)piridin-2-il, imidazo-(4,5-c)-piridin-2-il, imidazo(1,2-c)pirimidin-2-il, imidazo(1,2-a)pirazin-2-il, imidazo-(1,2-b)-piridizin-2-il, purin-8-il, imidazo(4,5-b)pirazin-2-il, imidazo(4,5-c)piridazin-2-il ili imidazo(4,5-d)piridazin-2-il grupu, piridil grupu, ili u datom slučaju, u 1-položaju, sa alkil ili benzil grupom preko ugljenika vezanu imidazolil grupu; R3, alkil grupu sa 1 do 5 atoma ugljenika ili cikloalkil grupu sa 3 do 5 atoma ugljenika, R4, karboksi ili 1H-tetrazolil grupu,i njihove 1-, 3-izomerne smeše i njihove soli kao i postupci za njihovo dobijanje.Nova jedinjenja predstavljaju naročito angiotenzijske antagoniste.
The invention relates to novel pyrimidine-containing derivatives having biological activity and pharmaceutical composition based thereon. Derivatives of benzimidazole of the general formula (1) EMBED ISISServer (1) where: r1 = C1-Сз-alkyl or C1, R2 = in position 6: benzimidazole-2-yl, tetrahydrobenzimidazole-1-yl, 1-methyl benzimidazole-2-yl, phthalimidobenzimidazole-1-yl, 1-oxoimidazole-2-yl, 1-oxoisoindole-2-yl, 2-oxopiperidine-1-yl, butansultam-1-yl, N-benzosulfonylmethylamino, imidazo[1,2-a]pyridine-2-yl, 5, 6, 7, 8-tetrahydroimidazo[1,2-a]pyridine-2-yl, imidazo[2,1-b]thiazol-6-yl, pyridine-2-yl, 1-isopropylimidazole-4-yl, isopropylcarbonylamino, 2,3-dimethylmaleinimido, morpholinecarbonylamino, cyclohexylaminocarbonylamino, amidino or, in the position 7, group of the formula EMBED ISISServer where: n=2-5, Rз = Et, n-Pr, n-Bu, R4 = CO2H or 1H-tetrazol-5-yl, in the form of a mixture of isomers, separate isomers, hydrates and salts. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_YU9892A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>YU9892A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_YU9892A3</originalsourceid><addsrcrecordid>eNqFi7EOgkAQRGksjPoHFvsBXKE0Up7HEjY52MvtGSMNIeasjJDg_0dI6K1eZubNNhmu2LRUU6FbtigphArJw0mlkKWKhGv0ZMBw7VgoEDcCuilWTbQNcxa4o7UL5xqcZ4MiULJfNefRaa-X9z7ZvPr3FA8rd8mxxGAqFcehi9PYP-MnfrvHLb_kZ539mX8z7jU4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>BENZIMIDAZOLES, THEIR 1-, 3,-ISOMERIC COMPOSITIONS AND THEIR SALTS AS WELL AS THE PROCESS FOR THEIR PREPARATION</title><source>esp@cenet</source><creator>HAUEL, NORBERT DR ; VAN MEEL, JACQUES DR ; RIES, UWE DR ; WIENEN, WOLFGANG DR ; ENTZEROTH, MICHAEL DR ; NARR, BERTHOLD DR</creator><creatorcontrib>HAUEL, NORBERT DR ; VAN MEEL, JACQUES DR ; RIES, UWE DR ; WIENEN, WOLFGANG DR ; ENTZEROTH, MICHAEL DR ; NARR, BERTHOLD DR</creatorcontrib><description>Opisani su benzimidazoli, formule u kojoj označavaju R1, fluor, hlor ili brom, alkil, cikloalkil, fluormetil, difluormetil ili trifluormetil grupu; R2, u datom slučaju, sa jednom ili dve alkil grupe ili sa tetrametilen ili pentametilen grupom supstituisanu 5-, 6-ili 7-članu alkilenimino ili alkenilenimino grupu, sa alkil ili fenil grupom mono ili disupstituisanu imido grupu maleinske kiseline, u 1-položaju, sa alkil grupom, sa 1 do 6 atoma ugljenika, ili sa cikloalkil grupom supstituisanu benzimidazol-2-il ili 4,5,6,7-tetrahidro-benzimidazol-2-il grupu, imidazo(2,1-b)tiazol-6-il, imidazo(1,2-a)piridin-2-il, 5,6,7,8-tetrahidro-imidazo-(1,2-a)-piridin-2-il, imidazo(1,2-a)pirimidin-2-il, imidazo(4,5-b)piridin-2-il, imidazo-(4,5-c)-piridin-2-il, imidazo(1,2-c)pirimidin-2-il, imidazo(1,2-a)pirazin-2-il, imidazo-(1,2-b)-piridizin-2-il, purin-8-il, imidazo(4,5-b)pirazin-2-il, imidazo(4,5-c)piridazin-2-il ili imidazo(4,5-d)piridazin-2-il grupu, piridil grupu, ili u datom slučaju, u 1-položaju, sa alkil ili benzil grupom preko ugljenika vezanu imidazolil grupu; R3, alkil grupu sa 1 do 5 atoma ugljenika ili cikloalkil grupu sa 3 do 5 atoma ugljenika, R4, karboksi ili 1H-tetrazolil grupu,i njihove 1-, 3-izomerne smeše i njihove soli kao i postupci za njihovo dobijanje.Nova jedinjenja predstavljaju naročito angiotenzijske antagoniste.
The invention relates to novel pyrimidine-containing derivatives having biological activity and pharmaceutical composition based thereon. Derivatives of benzimidazole of the general formula (1) EMBED ISISServer (1) where: r1 = C1-Сз-alkyl or C1, R2 = in position 6: benzimidazole-2-yl, tetrahydrobenzimidazole-1-yl, 1-methyl benzimidazole-2-yl, phthalimidobenzimidazole-1-yl, 1-oxoimidazole-2-yl, 1-oxoisoindole-2-yl, 2-oxopiperidine-1-yl, butansultam-1-yl, N-benzosulfonylmethylamino, imidazo[1,2-a]pyridine-2-yl, 5, 6, 7, 8-tetrahydroimidazo[1,2-a]pyridine-2-yl, imidazo[2,1-b]thiazol-6-yl, pyridine-2-yl, 1-isopropylimidazole-4-yl, isopropylcarbonylamino, 2,3-dimethylmaleinimido, morpholinecarbonylamino, cyclohexylaminocarbonylamino, amidino or, in the position 7, group of the formula EMBED ISISServer where: n=2-5, Rз = Et, n-Pr, n-Bu, R4 = CO2H or 1H-tetrazol-5-yl, in the form of a mixture of isomers, separate isomers, hydrates and salts.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990304&DB=EPODOC&CC=YU&NR=9892A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990304&DB=EPODOC&CC=YU&NR=9892A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HAUEL, NORBERT DR</creatorcontrib><creatorcontrib>VAN MEEL, JACQUES DR</creatorcontrib><creatorcontrib>RIES, UWE DR</creatorcontrib><creatorcontrib>WIENEN, WOLFGANG DR</creatorcontrib><creatorcontrib>ENTZEROTH, MICHAEL DR</creatorcontrib><creatorcontrib>NARR, BERTHOLD DR</creatorcontrib><title>BENZIMIDAZOLES, THEIR 1-, 3,-ISOMERIC COMPOSITIONS AND THEIR SALTS AS WELL AS THE PROCESS FOR THEIR PREPARATION</title><description>Opisani su benzimidazoli, formule u kojoj označavaju R1, fluor, hlor ili brom, alkil, cikloalkil, fluormetil, difluormetil ili trifluormetil grupu; R2, u datom slučaju, sa jednom ili dve alkil grupe ili sa tetrametilen ili pentametilen grupom supstituisanu 5-, 6-ili 7-članu alkilenimino ili alkenilenimino grupu, sa alkil ili fenil grupom mono ili disupstituisanu imido grupu maleinske kiseline, u 1-položaju, sa alkil grupom, sa 1 do 6 atoma ugljenika, ili sa cikloalkil grupom supstituisanu benzimidazol-2-il ili 4,5,6,7-tetrahidro-benzimidazol-2-il grupu, imidazo(2,1-b)tiazol-6-il, imidazo(1,2-a)piridin-2-il, 5,6,7,8-tetrahidro-imidazo-(1,2-a)-piridin-2-il, imidazo(1,2-a)pirimidin-2-il, imidazo(4,5-b)piridin-2-il, imidazo-(4,5-c)-piridin-2-il, imidazo(1,2-c)pirimidin-2-il, imidazo(1,2-a)pirazin-2-il, imidazo-(1,2-b)-piridizin-2-il, purin-8-il, imidazo(4,5-b)pirazin-2-il, imidazo(4,5-c)piridazin-2-il ili imidazo(4,5-d)piridazin-2-il grupu, piridil grupu, ili u datom slučaju, u 1-položaju, sa alkil ili benzil grupom preko ugljenika vezanu imidazolil grupu; R3, alkil grupu sa 1 do 5 atoma ugljenika ili cikloalkil grupu sa 3 do 5 atoma ugljenika, R4, karboksi ili 1H-tetrazolil grupu,i njihove 1-, 3-izomerne smeše i njihove soli kao i postupci za njihovo dobijanje.Nova jedinjenja predstavljaju naročito angiotenzijske antagoniste.
The invention relates to novel pyrimidine-containing derivatives having biological activity and pharmaceutical composition based thereon. Derivatives of benzimidazole of the general formula (1) EMBED ISISServer (1) where: r1 = C1-Сз-alkyl or C1, R2 = in position 6: benzimidazole-2-yl, tetrahydrobenzimidazole-1-yl, 1-methyl benzimidazole-2-yl, phthalimidobenzimidazole-1-yl, 1-oxoimidazole-2-yl, 1-oxoisoindole-2-yl, 2-oxopiperidine-1-yl, butansultam-1-yl, N-benzosulfonylmethylamino, imidazo[1,2-a]pyridine-2-yl, 5, 6, 7, 8-tetrahydroimidazo[1,2-a]pyridine-2-yl, imidazo[2,1-b]thiazol-6-yl, pyridine-2-yl, 1-isopropylimidazole-4-yl, isopropylcarbonylamino, 2,3-dimethylmaleinimido, morpholinecarbonylamino, cyclohexylaminocarbonylamino, amidino or, in the position 7, group of the formula EMBED ISISServer where: n=2-5, Rз = Et, n-Pr, n-Bu, R4 = CO2H or 1H-tetrazol-5-yl, in the form of a mixture of isomers, separate isomers, hydrates and salts.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFi7EOgkAQRGksjPoHFvsBXKE0Up7HEjY52MvtGSMNIeasjJDg_0dI6K1eZubNNhmu2LRUU6FbtigphArJw0mlkKWKhGv0ZMBw7VgoEDcCuilWTbQNcxa4o7UL5xqcZ4MiULJfNefRaa-X9z7ZvPr3FA8rd8mxxGAqFcehi9PYP-MnfrvHLb_kZ539mX8z7jU4</recordid><startdate>19990304</startdate><enddate>19990304</enddate><creator>HAUEL, NORBERT DR</creator><creator>VAN MEEL, JACQUES DR</creator><creator>RIES, UWE DR</creator><creator>WIENEN, WOLFGANG DR</creator><creator>ENTZEROTH, MICHAEL DR</creator><creator>NARR, BERTHOLD DR</creator><scope>EVB</scope></search><sort><creationdate>19990304</creationdate><title>BENZIMIDAZOLES, THEIR 1-, 3,-ISOMERIC COMPOSITIONS AND THEIR SALTS AS WELL AS THE PROCESS FOR THEIR PREPARATION</title><author>HAUEL, NORBERT DR ; VAN MEEL, JACQUES DR ; RIES, UWE DR ; WIENEN, WOLFGANG DR ; ENTZEROTH, MICHAEL DR ; NARR, BERTHOLD DR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_YU9892A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1999</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>HAUEL, NORBERT DR</creatorcontrib><creatorcontrib>VAN MEEL, JACQUES DR</creatorcontrib><creatorcontrib>RIES, UWE DR</creatorcontrib><creatorcontrib>WIENEN, WOLFGANG DR</creatorcontrib><creatorcontrib>ENTZEROTH, MICHAEL DR</creatorcontrib><creatorcontrib>NARR, BERTHOLD DR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HAUEL, NORBERT DR</au><au>VAN MEEL, JACQUES DR</au><au>RIES, UWE DR</au><au>WIENEN, WOLFGANG DR</au><au>ENTZEROTH, MICHAEL DR</au><au>NARR, BERTHOLD DR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BENZIMIDAZOLES, THEIR 1-, 3,-ISOMERIC COMPOSITIONS AND THEIR SALTS AS WELL AS THE PROCESS FOR THEIR PREPARATION</title><date>1999-03-04</date><risdate>1999</risdate><abstract>Opisani su benzimidazoli, formule u kojoj označavaju R1, fluor, hlor ili brom, alkil, cikloalkil, fluormetil, difluormetil ili trifluormetil grupu; R2, u datom slučaju, sa jednom ili dve alkil grupe ili sa tetrametilen ili pentametilen grupom supstituisanu 5-, 6-ili 7-članu alkilenimino ili alkenilenimino grupu, sa alkil ili fenil grupom mono ili disupstituisanu imido grupu maleinske kiseline, u 1-položaju, sa alkil grupom, sa 1 do 6 atoma ugljenika, ili sa cikloalkil grupom supstituisanu benzimidazol-2-il ili 4,5,6,7-tetrahidro-benzimidazol-2-il grupu, imidazo(2,1-b)tiazol-6-il, imidazo(1,2-a)piridin-2-il, 5,6,7,8-tetrahidro-imidazo-(1,2-a)-piridin-2-il, imidazo(1,2-a)pirimidin-2-il, imidazo(4,5-b)piridin-2-il, imidazo-(4,5-c)-piridin-2-il, imidazo(1,2-c)pirimidin-2-il, imidazo(1,2-a)pirazin-2-il, imidazo-(1,2-b)-piridizin-2-il, purin-8-il, imidazo(4,5-b)pirazin-2-il, imidazo(4,5-c)piridazin-2-il ili imidazo(4,5-d)piridazin-2-il grupu, piridil grupu, ili u datom slučaju, u 1-položaju, sa alkil ili benzil grupom preko ugljenika vezanu imidazolil grupu; R3, alkil grupu sa 1 do 5 atoma ugljenika ili cikloalkil grupu sa 3 do 5 atoma ugljenika, R4, karboksi ili 1H-tetrazolil grupu,i njihove 1-, 3-izomerne smeše i njihove soli kao i postupci za njihovo dobijanje.Nova jedinjenja predstavljaju naročito angiotenzijske antagoniste.
The invention relates to novel pyrimidine-containing derivatives having biological activity and pharmaceutical composition based thereon. Derivatives of benzimidazole of the general formula (1) EMBED ISISServer (1) where: r1 = C1-Сз-alkyl or C1, R2 = in position 6: benzimidazole-2-yl, tetrahydrobenzimidazole-1-yl, 1-methyl benzimidazole-2-yl, phthalimidobenzimidazole-1-yl, 1-oxoimidazole-2-yl, 1-oxoisoindole-2-yl, 2-oxopiperidine-1-yl, butansultam-1-yl, N-benzosulfonylmethylamino, imidazo[1,2-a]pyridine-2-yl, 5, 6, 7, 8-tetrahydroimidazo[1,2-a]pyridine-2-yl, imidazo[2,1-b]thiazol-6-yl, pyridine-2-yl, 1-isopropylimidazole-4-yl, isopropylcarbonylamino, 2,3-dimethylmaleinimido, morpholinecarbonylamino, cyclohexylaminocarbonylamino, amidino or, in the position 7, group of the formula EMBED ISISServer where: n=2-5, Rз = Et, n-Pr, n-Bu, R4 = CO2H or 1H-tetrazol-5-yl, in the form of a mixture of isomers, separate isomers, hydrates and salts.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | BENZIMIDAZOLES, THEIR 1-, 3,-ISOMERIC COMPOSITIONS AND THEIR SALTS AS WELL AS THE PROCESS FOR THEIR PREPARATION |
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