STREPTOMYCES AVERMITILIS GENE DIRECTING THE RATIO OF B2:B1 AVERMECTINS

The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further...

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1. Verfasser: STUTZMAN-ENGWALL, KIM JONELLE
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description The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced. Ovaj pronalazak se odnosi na polinukleotidne molekule koji sadrže nukleotidne sekvence koje kodiraju produkt aveC gena, gde ti polinukelotidni molekuli mogu biti korišćeni da izmene odnos ili količinu klase 2:1 avermektina proizvedenih u fermentacionim kulturama S. avermitilis Ovaj pronalazak se dalje odnosi na vektore, ćelije domaćine, i mutante sojeve S. avermitilis u kojima je aveC gen inaktiviran, ili mutiran tako da menja odnos ili količinu klase 2:1 proizvedenih avermektina.[The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
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The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced. Ovaj pronalazak se odnosi na polinukleotidne molekule koji sadrže nukleotidne sekvence koje kodiraju produkt aveC gena, gde ti polinukelotidni molekuli mogu biti korišćeni da izmene odnos ili količinu klase 2:1 avermektina proizvedenih u fermentacionim kulturama S. avermitilis Ovaj pronalazak se dalje odnosi na vektore, ćelije domaćine, i mutante sojeve S. avermitilis u kojima je aveC gen inaktiviran, ili mutiran tako da menja odnos ili količinu klase 2:1 proizvedenih avermektina.[The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. 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The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced. Ovaj pronalazak se odnosi na polinukleotidne molekule koji sadrže nukleotidne sekvence koje kodiraju produkt aveC gena, gde ti polinukelotidni molekuli mogu biti korišćeni da izmene odnos ili količinu klase 2:1 avermektina proizvedenih u fermentacionim kulturama S. avermitilis Ovaj pronalazak se dalje odnosi na vektore, ćelije domaćine, i mutante sojeve S. avermitilis u kojima je aveC gen inaktiviran, ili mutiran tako da menja odnos ili količinu klase 2:1 proizvedenih avermektina.[The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. 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The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced. Ovaj pronalazak se odnosi na polinukleotidne molekule koji sadrže nukleotidne sekvence koje kodiraju produkt aveC gena, gde ti polinukelotidni molekuli mogu biti korišćeni da izmene odnos ili količinu klase 2:1 avermektina proizvedenih u fermentacionim kulturama S. avermitilis Ovaj pronalazak se dalje odnosi na vektore, ćelije domaćine, i mutante sojeve S. avermitilis u kojima je aveC gen inaktiviran, ili mutiran tako da menja odnos ili količinu klase 2:1 proizvedenih avermektina.[The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.</abstract><oa>free_for_read</oa></addata></record>
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subjects AGRICULTURE
ANIMAL HUSBANDRY
BEER
BIOCHEMISTRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TRAPPING
VINEGAR
WINE
title STREPTOMYCES AVERMITILIS GENE DIRECTING THE RATIO OF B2:B1 AVERMECTINS
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