PROCESS FOR PREPARING NOVEL AZEPINE DERIVATIVES

1321509 Hypotensive &c medicines DR KARL THOMAE GmbH 13 Aug 1971 [14 Aug 1970 2 June 1971] 38160/71 Heading ASB [Also in Division C2] Pharmaceutical compositions having hypotensive, sedative, antitussive and/or antiphlogistic activity, for oral, rectal or parenteral administration, comprise a compound I: (in which R 1 is H, C 1-4 alkyl, C 1-4 hydroxyalkyl, allyl, cycloalkyl, hexahydrobenzyl, phenyl, phenylethyl or benzyl, the benzyl group optionally being substituted by 1 or 2 halogen atoms, 1 to 3 methoxy groups, a CF 3 group or a C 1-3 alkyl group, X is O or S, and R 2 is H, C 1-5 alkyl, allyl, cycloalkyl, phenyl, benzyl or phenylethyl, with the proviso that when X is O, R 2 is H) or a pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutical carrier. The compositions may also comprise other active ingredients, e.g. codeine phosphate and 2, 6-bis-(diethanolamino)-4, 8-dipiperidino-pyrimido [5, 4- d] pyrimidine.