PROCESS FOR OBTAINING BICYCLIC THROMBOXANE SYNTHETASE INHIBITORS
Compounds of the formula: wherein R , which is attached to a carbon atom of ring "B", is hydrogen, halo, C1-C4 alkyl, or -S(C1-C4 alkyl); Y, which is attached to ring "A", is -CN, -COOH, -COO(C1-C4 alkyl) or -CONH2; X is O, S, NH, N(C1-C4 alkyl) or -CH=CH-; and R, which is attach...
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| creator | CROSS P.E DICKINSON R.P |
| description | Compounds of the formula:
wherein
R , which is attached to a carbon atom of ring "B", is hydrogen, halo, C1-C4 alkyl, or -S(C1-C4 alkyl);
Y, which is attached to ring "A", is -CN, -COOH, -COO(C1-C4 alkyl) or -CONH2;
X is O, S, NH, N(C1-C4 alkyl) or -CH=CH-;
and
R, which is attached to carbon atom of ring "B", is a group of the formula:
where Z is -CH2-, -CH=CH-, -OCH2-, -CO- or -S-;
and the pharmaceutically, acceptable salts thereof.
The compounds in which Y is -COOH, -CCO(C1-C4 alkyl) and -CONH2 are pharmaceutical agents being selective thromboxane synthetase inhibitors. Those in which Y is -CN are useful intermediates. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_YU180184A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>YU180184A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_YU180184A3</originalsourceid><addsrcrecordid>eNrjZHAICPJ3dg0OVnDzD1Lwdwpx9PTz9HNXcPJ0jnT28XRWCPEI8vd18o9w9HNVCI70C_FwDXEMdlXw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDHJuriHOHrqpBfnxqcUFicmpeakl8ZGhhhYGhhYmjsYEFQAA6VwqFA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PROCESS FOR OBTAINING BICYCLIC THROMBOXANE SYNTHETASE INHIBITORS</title><source>esp@cenet</source><creator>CROSS P.E ; DICKINSON R.P</creator><creatorcontrib>CROSS P.E ; DICKINSON R.P</creatorcontrib><description>Compounds of the formula:
wherein
R , which is attached to a carbon atom of ring "B", is hydrogen, halo, C1-C4 alkyl, or -S(C1-C4 alkyl);
Y, which is attached to ring "A", is -CN, -COOH, -COO(C1-C4 alkyl) or -CONH2;
X is O, S, NH, N(C1-C4 alkyl) or -CH=CH-;
and
R, which is attached to carbon atom of ring "B", is a group of the formula:
where Z is -CH2-, -CH=CH-, -OCH2-, -CO- or -S-;
and the pharmaceutically, acceptable salts thereof.
The compounds in which Y is -COOH, -CCO(C1-C4 alkyl) and -CONH2 are pharmaceutical agents being selective thromboxane synthetase inhibitors. Those in which Y is -CN are useful intermediates.</description><edition>2</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1985</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19850430&DB=EPODOC&CC=YU&NR=180184A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19850430&DB=EPODOC&CC=YU&NR=180184A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CROSS P.E</creatorcontrib><creatorcontrib>DICKINSON R.P</creatorcontrib><title>PROCESS FOR OBTAINING BICYCLIC THROMBOXANE SYNTHETASE INHIBITORS</title><description>Compounds of the formula:
wherein
R , which is attached to a carbon atom of ring "B", is hydrogen, halo, C1-C4 alkyl, or -S(C1-C4 alkyl);
Y, which is attached to ring "A", is -CN, -COOH, -COO(C1-C4 alkyl) or -CONH2;
X is O, S, NH, N(C1-C4 alkyl) or -CH=CH-;
and
R, which is attached to carbon atom of ring "B", is a group of the formula:
where Z is -CH2-, -CH=CH-, -OCH2-, -CO- or -S-;
and the pharmaceutically, acceptable salts thereof.
The compounds in which Y is -COOH, -CCO(C1-C4 alkyl) and -CONH2 are pharmaceutical agents being selective thromboxane synthetase inhibitors. Those in which Y is -CN are useful intermediates.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1985</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAICPJ3dg0OVnDzD1Lwdwpx9PTz9HNXcPJ0jnT28XRWCPEI8vd18o9w9HNVCI70C_FwDXEMdlXw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDHJuriHOHrqpBfnxqcUFicmpeakl8ZGhhhYGhhYmjsYEFQAA6VwqFA</recordid><startdate>19850430</startdate><enddate>19850430</enddate><creator>CROSS P.E</creator><creator>DICKINSON R.P</creator><scope>EVB</scope></search><sort><creationdate>19850430</creationdate><title>PROCESS FOR OBTAINING BICYCLIC THROMBOXANE SYNTHETASE INHIBITORS</title><author>CROSS P.E ; DICKINSON R.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_YU180184A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1985</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CROSS P.E</creatorcontrib><creatorcontrib>DICKINSON R.P</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CROSS P.E</au><au>DICKINSON R.P</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR OBTAINING BICYCLIC THROMBOXANE SYNTHETASE INHIBITORS</title><date>1985-04-30</date><risdate>1985</risdate><abstract>Compounds of the formula:
wherein
R , which is attached to a carbon atom of ring "B", is hydrogen, halo, C1-C4 alkyl, or -S(C1-C4 alkyl);
Y, which is attached to ring "A", is -CN, -COOH, -COO(C1-C4 alkyl) or -CONH2;
X is O, S, NH, N(C1-C4 alkyl) or -CH=CH-;
and
R, which is attached to carbon atom of ring "B", is a group of the formula:
where Z is -CH2-, -CH=CH-, -OCH2-, -CO- or -S-;
and the pharmaceutically, acceptable salts thereof.
The compounds in which Y is -COOH, -CCO(C1-C4 alkyl) and -CONH2 are pharmaceutical agents being selective thromboxane synthetase inhibitors. Those in which Y is -CN are useful intermediates.</abstract><edition>2</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROCESS FOR OBTAINING BICYCLIC THROMBOXANE SYNTHETASE INHIBITORS |
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