PROCESS FOR OBTAINING 5-(E)-(2-BROMOVINYL)-2'-DEOXYURIDINE

PROCESS FOR OBTAINING 5-(E)-(2-BROMOVINYL)-2'-DEOXYURIDINE

(E)-5-(2-bromovinyl)-2'- deoxyuridine and its derivatives of general formula VI (where R is H or as defined below) are prepared from 3,5'-di-O-acyl-5-ethyl- 2'-deoxyuridines of general formula IV (wherein R is C1-8 alkanoyl, benzoyl or benzoyl group substituted in para position by C1-...

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Bibliographische Detailangaben
Hauptverfasser: OETVOES L, REEFSCHLAGER J, VOROESHALZY L, GAL T, RATONYI Z, JUST H, SZABOLCS A, TUEDOES H, SAGI J, DAROCZY I, BARWOLF D
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:(E)-5-(2-bromovinyl)-2'- deoxyuridine and its derivatives of general formula VI (where R is H or as defined below) are prepared from 3,5'-di-O-acyl-5-ethyl- 2'-deoxyuridines of general formula IV (wherein R is C1-8 alkanoyl, benzoyl or benzoyl group substituted in para position by C1-4 alkyl or halogen) by reaction with bromine to give a dibromo derivative of general formula V which is then dehydrohalogenated and if desired deacylated to give the compound of formula of formula (VI) in which R is H. The compounds of formula (VI) in which R is other than H are new compounds and are metabolic precursors for (E)-5-(2-bromovinyl-2'- deoxyuridine. These compounds are thus useful in medicine.