PROCESS FOR MAKING 1,4 DIHYDROPIRIDINE
Dihydropyridines of the formula:- and their pharmaceutically acceptable acid addition salts wherein Y is -(CH2)2-, -(CH2)3-, -CH2CH(CH3)- or -CH2C(CH3)2-; R is aryl or heteroaryl; R and R are each independently C1-C4 alkyl or 2-methoxyethyl; and R is hydrogen, C1-C4 alkyl, 2-(C1-C4 alkoxyl) ethyl, c...
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| creator | CAMPBELL S.F STUBBS J.K CROSS P.E |
| description | Dihydropyridines of the formula:-
and their pharmaceutically acceptable acid addition salts
wherein Y is -(CH2)2-, -(CH2)3-, -CH2CH(CH3)- or -CH2C(CH3)2-;
R is aryl or heteroaryl;
R and R are each independently C1-C4 alkyl or 2-methoxyethyl; and
R is hydrogen, C1-C4 alkyl, 2-(C1-C4 alkoxyl) ethyl, cyclopropylmethyl, benzyl, or -(CH2)mCOR where m is 1, 2 or 3 and R is hydroxy, C1-C4 alkoxy or - NR5 where R and R are each independently hydrogen or C1-C4 alkyl, pharmaceutical compositions containing them, and processes for their production.
The compounds are particularly useful in the treatment or prevention of a variety of cardiac conditions, e.g, angina pectoris. |
| format | Patent |
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and their pharmaceutically acceptable acid addition salts
wherein Y is -(CH2)2-, -(CH2)3-, -CH2CH(CH3)- or -CH2C(CH3)2-;
R is aryl or heteroaryl;
R and R are each independently C1-C4 alkyl or 2-methoxyethyl; and
R is hydrogen, C1-C4 alkyl, 2-(C1-C4 alkoxyl) ethyl, cyclopropylmethyl, benzyl, or -(CH2)mCOR where m is 1, 2 or 3 and R is hydroxy, C1-C4 alkoxy or - NR5 where R and R are each independently hydrogen or C1-C4 alkyl, pharmaceutical compositions containing them, and processes for their production.
The compounds are particularly useful in the treatment or prevention of a variety of cardiac conditions, e.g, angina pectoris.</description><edition>2</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1986</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19860630&DB=EPODOC&CC=YU&NR=141985A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19860630&DB=EPODOC&CC=YU&NR=141985A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CAMPBELL S.F</creatorcontrib><creatorcontrib>STUBBS J.K</creatorcontrib><creatorcontrib>CROSS P.E</creatorcontrib><title>PROCESS FOR MAKING 1,4 DIHYDROPIRIDINE</title><description>Dihydropyridines of the formula:-
and their pharmaceutically acceptable acid addition salts
wherein Y is -(CH2)2-, -(CH2)3-, -CH2CH(CH3)- or -CH2C(CH3)2-;
R is aryl or heteroaryl;
R and R are each independently C1-C4 alkyl or 2-methoxyethyl; and
R is hydrogen, C1-C4 alkyl, 2-(C1-C4 alkoxyl) ethyl, cyclopropylmethyl, benzyl, or -(CH2)mCOR where m is 1, 2 or 3 and R is hydroxy, C1-C4 alkoxy or - NR5 where R and R are each independently hydrogen or C1-C4 alkyl, pharmaceutical compositions containing them, and processes for their production.
The compounds are particularly useful in the treatment or prevention of a variety of cardiac conditions, e.g, angina pectoris.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1986</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFALCPJ3dg0OVnDzD1LwdfT29HNXMNQxUXDx9Ih0CfIP8AzydPH0c-VhYE1LzClO5YXS3Axybq4hzh66qQX58anFBYnJqXmpJfGRoYYmhpYWpo7GBBUAAOI3Ik4</recordid><startdate>19860630</startdate><enddate>19860630</enddate><creator>CAMPBELL S.F</creator><creator>STUBBS J.K</creator><creator>CROSS P.E</creator><scope>EVB</scope></search><sort><creationdate>19860630</creationdate><title>PROCESS FOR MAKING 1,4 DIHYDROPIRIDINE</title><author>CAMPBELL S.F ; STUBBS J.K ; CROSS P.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_YU141985A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1986</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CAMPBELL S.F</creatorcontrib><creatorcontrib>STUBBS J.K</creatorcontrib><creatorcontrib>CROSS P.E</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CAMPBELL S.F</au><au>STUBBS J.K</au><au>CROSS P.E</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR MAKING 1,4 DIHYDROPIRIDINE</title><date>1986-06-30</date><risdate>1986</risdate><abstract>Dihydropyridines of the formula:-
and their pharmaceutically acceptable acid addition salts
wherein Y is -(CH2)2-, -(CH2)3-, -CH2CH(CH3)- or -CH2C(CH3)2-;
R is aryl or heteroaryl;
R and R are each independently C1-C4 alkyl or 2-methoxyethyl; and
R is hydrogen, C1-C4 alkyl, 2-(C1-C4 alkoxyl) ethyl, cyclopropylmethyl, benzyl, or -(CH2)mCOR where m is 1, 2 or 3 and R is hydroxy, C1-C4 alkoxy or - NR5 where R and R are each independently hydrogen or C1-C4 alkyl, pharmaceutical compositions containing them, and processes for their production.
The compounds are particularly useful in the treatment or prevention of a variety of cardiac conditions, e.g, angina pectoris.</abstract><edition>2</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROCESS FOR MAKING 1,4 DIHYDROPIRIDINE |
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