NOVEL CEPHALOTAXANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alcaloïds used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor wh...
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| creator | CHAUVIAT, LUDOVIC POUTOT, SANDRINE ROBIN, JEAN-PIERRE CHARBONNEL, SANDRA DHAL, ROBERT GIRODIER, LAURENT GILET, CHRYSTELLE DUJARDIN, GILLES ROBIN, JULIE ROUAUD, SYLVIE CAVOLEAU, SYLVIE MEVELEC, LAURENCE FOURNIER, FLORENCE |
| description | The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alcaloïds used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.
L'invention concerne une nouvelle méthode permettant d'effectuer une semi-synthèse asymétrique d'haringtonines et de leurs analogues, qui sont des alcaloïdes utilisés en chimiothérapie. Cette méthode comprend l'estérification directe d'une céphalotaxine avec un composé d'acylation constitué d'un précurseur de chaîne latérale dont le squelette et les groupes fonctionnels sont entièrement préformés. |
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L'invention concerne une nouvelle méthode permettant d'effectuer une semi-synthèse asymétrique d'haringtonines et de leurs analogues, qui sont des alcaloïdes utilisés en chimiothérapie. Cette méthode comprend l'estérification directe d'une céphalotaxine avec un composé d'acylation constitué d'un précurseur de chaîne latérale dont le squelette et les groupes fonctionnels sont entièrement préformés.</description><edition>6</edition><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991104&DB=EPODOC&CC=WO&NR=9948894B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991104&DB=EPODOC&CC=WO&NR=9948894B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHAUVIAT, LUDOVIC</creatorcontrib><creatorcontrib>POUTOT, SANDRINE</creatorcontrib><creatorcontrib>ROBIN, JEAN-PIERRE</creatorcontrib><creatorcontrib>CHARBONNEL, SANDRA</creatorcontrib><creatorcontrib>DHAL, ROBERT</creatorcontrib><creatorcontrib>GIRODIER, LAURENT</creatorcontrib><creatorcontrib>GILET, CHRYSTELLE</creatorcontrib><creatorcontrib>DUJARDIN, GILLES</creatorcontrib><creatorcontrib>ROBIN, JULIE</creatorcontrib><creatorcontrib>ROUAUD, SYLVIE</creatorcontrib><creatorcontrib>CAVOLEAU, SYLVIE</creatorcontrib><creatorcontrib>MEVELEC, LAURENCE</creatorcontrib><creatorcontrib>FOURNIER, FLORENCE</creatorcontrib><title>NOVEL CEPHALOTAXANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION</title><description>The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alcaloïds used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.
L'invention concerne une nouvelle méthode permettant d'effectuer une semi-synthèse asymétrique d'haringtonines et de leurs analogues, qui sont des alcaloïdes utilisés en chimiothérapie. Cette méthode comprend l'estérification directe d'une céphalotaxine avec un composé d'acylation constitué d'un précurseur de chaîne latérale dont le squelette et les groupes fonctionnels sont entièrement préformés.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD08w9z9VFwdg3wcPTxD3GMcPRzVXBxDfIMcwzxDHMNVnD0c1EICPJ3dg0OVnDzD1II8XD1DAKKuAY4BgGV-PvxMLCmJeYUp_JCaW4GBTfXEGcP3dSC_PjU4oLE5NS81JL4cH9LSxMLC0sTJ0NjIpQAAKjhKxs</recordid><startdate>19991104</startdate><enddate>19991104</enddate><creator>CHAUVIAT, LUDOVIC</creator><creator>POUTOT, SANDRINE</creator><creator>ROBIN, JEAN-PIERRE</creator><creator>CHARBONNEL, SANDRA</creator><creator>DHAL, ROBERT</creator><creator>GIRODIER, LAURENT</creator><creator>GILET, CHRYSTELLE</creator><creator>DUJARDIN, GILLES</creator><creator>ROBIN, JULIE</creator><creator>ROUAUD, SYLVIE</creator><creator>CAVOLEAU, SYLVIE</creator><creator>MEVELEC, LAURENCE</creator><creator>FOURNIER, FLORENCE</creator><scope>EVB</scope></search><sort><creationdate>19991104</creationdate><title>NOVEL CEPHALOTAXANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION</title><author>CHAUVIAT, LUDOVIC ; POUTOT, SANDRINE ; ROBIN, JEAN-PIERRE ; CHARBONNEL, SANDRA ; DHAL, ROBERT ; GIRODIER, LAURENT ; GILET, CHRYSTELLE ; DUJARDIN, GILLES ; ROBIN, JULIE ; ROUAUD, SYLVIE ; CAVOLEAU, SYLVIE ; MEVELEC, LAURENCE ; FOURNIER, FLORENCE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9948894B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1999</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHAUVIAT, LUDOVIC</creatorcontrib><creatorcontrib>POUTOT, SANDRINE</creatorcontrib><creatorcontrib>ROBIN, JEAN-PIERRE</creatorcontrib><creatorcontrib>CHARBONNEL, SANDRA</creatorcontrib><creatorcontrib>DHAL, ROBERT</creatorcontrib><creatorcontrib>GIRODIER, LAURENT</creatorcontrib><creatorcontrib>GILET, CHRYSTELLE</creatorcontrib><creatorcontrib>DUJARDIN, GILLES</creatorcontrib><creatorcontrib>ROBIN, JULIE</creatorcontrib><creatorcontrib>ROUAUD, SYLVIE</creatorcontrib><creatorcontrib>CAVOLEAU, SYLVIE</creatorcontrib><creatorcontrib>MEVELEC, LAURENCE</creatorcontrib><creatorcontrib>FOURNIER, FLORENCE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHAUVIAT, LUDOVIC</au><au>POUTOT, SANDRINE</au><au>ROBIN, JEAN-PIERRE</au><au>CHARBONNEL, SANDRA</au><au>DHAL, ROBERT</au><au>GIRODIER, LAURENT</au><au>GILET, CHRYSTELLE</au><au>DUJARDIN, GILLES</au><au>ROBIN, JULIE</au><au>ROUAUD, SYLVIE</au><au>CAVOLEAU, SYLVIE</au><au>MEVELEC, LAURENCE</au><au>FOURNIER, FLORENCE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL CEPHALOTAXANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION</title><date>1999-11-04</date><risdate>1999</risdate><abstract>The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alcaloïds used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.
L'invention concerne une nouvelle méthode permettant d'effectuer une semi-synthèse asymétrique d'haringtonines et de leurs analogues, qui sont des alcaloïdes utilisés en chimiothérapie. Cette méthode comprend l'estérification directe d'une céphalotaxine avec un composé d'acylation constitué d'un précurseur de chaîne latérale dont le squelette et les groupes fonctionnels sont entièrement préformés.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL CEPHALOTAXANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION |
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