ANTI-VIRAL PYRIMIDINE DERIVATIVES
Compounds and compositions which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives having formula (I) wherein X is a member selected from the group consisting of -NR R , -OR , -SR , aryl, alkyl and...
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| creator | MIAO, SHIANG CUSHING, TIMOTHY, D MELLON, HEATHER, L CHEN, XIAOQI JAEN, JUAN, C POWERS, JAY, P FLYGARE, JOHN, A |
| description | Compounds and compositions which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives having formula (I) wherein X is a member selected from the group consisting of -NR R , -OR , -SR , aryl, alkyl and arylalkyl; Y is a member selected from the group consisting of a covalent bond, -N(R )-, -O-, -S-, -C(=O)- and alkylene; R and R are members independently selected from the group consisting of hydrogen, alkyl, -O-alkyl, -S-alkyl, aryl, arylalkyl, -O-aryl, -S-aryl, -NO2, -NR R , -C(O)R , -CO2R , -C(O)NR R , -N(R )C(O)R , -N(R )CO2R , -N(R )C(O)NR R , -S(O)mNR R , -S(O)nR , -CN, halogen, and -N(R )S(O)mR .
L'invention concerne des composés et des compositions convenant au traitement d'infections virales, et en particulier, chez l'homme, l'infection par Cytomégalovirus. Ces composés contiennent les dérivés à base de pyrimidine de l'invention, représentés par la formule générale (I). Dans cette formule, X appartient au groupe des -NR R , -OR , -SR , aryle, alkyle et arylalkyle; Y appartient au group constitué d'une liaison covalente, des -N(R )-, -O-, -S-, -C(=O)-, et de l'alkylène; R et R appartiennent chacun indépendamment au groupe des hydrogène, alkyle, -O-alkyle, -S-alkyle, aryle, arylalkyle, -O-aryle, -S-aryle, -NO2, -NR R , -C(O)R , -CO2R , -C(O)NR R , -N(R )C(O)R , -N(R )CO2R , -N(R )C(O)NR R , -S(O)mNR R , -S(O)nR , -CN, halogène, et -N(R )S(O)mR . |
| format | Patent |
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L'invention concerne des composés et des compositions convenant au traitement d'infections virales, et en particulier, chez l'homme, l'infection par Cytomégalovirus. Ces composés contiennent les dérivés à base de pyrimidine de l'invention, représentés par la formule générale (I). Dans cette formule, X appartient au groupe des -NR R , -OR , -SR , aryle, alkyle et arylalkyle; Y appartient au group constitué d'une liaison covalente, des -N(R )-, -O-, -S-, -C(=O)-, et de l'alkylène; R et R appartiennent chacun indépendamment au groupe des hydrogène, alkyle, -O-alkyle, -S-alkyle, aryle, arylalkyle, -O-aryle, -S-aryle, -NO2, -NR R , -C(O)R , -CO2R , -C(O)NR R , -N(R )C(O)R , -N(R )CO2R , -N(R )C(O)NR R , -S(O)mNR R , -S(O)nR , -CN, halogène, et -N(R )S(O)mR .</description><edition>6</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990819&DB=EPODOC&CC=WO&NR=9941253A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990819&DB=EPODOC&CC=WO&NR=9941253A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MIAO, SHIANG</creatorcontrib><creatorcontrib>CUSHING, TIMOTHY, D</creatorcontrib><creatorcontrib>MELLON, HEATHER, L</creatorcontrib><creatorcontrib>CHEN, XIAOQI</creatorcontrib><creatorcontrib>JAEN, JUAN, C</creatorcontrib><creatorcontrib>POWERS, JAY, P</creatorcontrib><creatorcontrib>FLYGARE, JOHN, A</creatorcontrib><title>ANTI-VIRAL PYRIMIDINE DERIVATIVES</title><description>Compounds and compositions which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives having formula (I) wherein X is a member selected from the group consisting of -NR R , -OR , -SR , aryl, alkyl and arylalkyl; Y is a member selected from the group consisting of a covalent bond, -N(R )-, -O-, -S-, -C(=O)- and alkylene; R and R are members independently selected from the group consisting of hydrogen, alkyl, -O-alkyl, -S-alkyl, aryl, arylalkyl, -O-aryl, -S-aryl, -NO2, -NR R , -C(O)R , -CO2R , -C(O)NR R , -N(R )C(O)R , -N(R )CO2R , -N(R )C(O)NR R , -S(O)mNR R , -S(O)nR , -CN, halogen, and -N(R )S(O)mR .
L'invention concerne des composés et des compositions convenant au traitement d'infections virales, et en particulier, chez l'homme, l'infection par Cytomégalovirus. Ces composés contiennent les dérivés à base de pyrimidine de l'invention, représentés par la formule générale (I). Dans cette formule, X appartient au groupe des -NR R , -OR , -SR , aryle, alkyle et arylalkyle; Y appartient au group constitué d'une liaison covalente, des -N(R )-, -O-, -S-, -C(=O)-, et de l'alkylène; R et R appartiennent chacun indépendamment au groupe des hydrogène, alkyle, -O-alkyle, -S-alkyle, aryle, arylalkyle, -O-aryle, -S-aryle, -NO2, -NR R , -C(O)R , -CO2R , -C(O)NR R , -N(R )C(O)R , -N(R )CO2R , -N(R )C(O)NR R , -S(O)mNR R , -S(O)nR , -CN, halogène, et -N(R )S(O)mR .</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB09Avx1A3zDHL0UQiIDPL09XTx9HNVcHEN8gxzDPEMcw3mYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXx4f6WliaGRqbGjobGRCgBAO-BIis</recordid><startdate>19990819</startdate><enddate>19990819</enddate><creator>MIAO, SHIANG</creator><creator>CUSHING, TIMOTHY, D</creator><creator>MELLON, HEATHER, L</creator><creator>CHEN, XIAOQI</creator><creator>JAEN, JUAN, C</creator><creator>POWERS, JAY, P</creator><creator>FLYGARE, JOHN, A</creator><scope>EVB</scope></search><sort><creationdate>19990819</creationdate><title>ANTI-VIRAL PYRIMIDINE DERIVATIVES</title><author>MIAO, SHIANG ; CUSHING, TIMOTHY, D ; MELLON, HEATHER, L ; CHEN, XIAOQI ; JAEN, JUAN, C ; POWERS, JAY, P ; FLYGARE, JOHN, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9941253A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1999</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MIAO, SHIANG</creatorcontrib><creatorcontrib>CUSHING, TIMOTHY, D</creatorcontrib><creatorcontrib>MELLON, HEATHER, L</creatorcontrib><creatorcontrib>CHEN, XIAOQI</creatorcontrib><creatorcontrib>JAEN, JUAN, C</creatorcontrib><creatorcontrib>POWERS, JAY, P</creatorcontrib><creatorcontrib>FLYGARE, JOHN, A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MIAO, SHIANG</au><au>CUSHING, TIMOTHY, D</au><au>MELLON, HEATHER, L</au><au>CHEN, XIAOQI</au><au>JAEN, JUAN, C</au><au>POWERS, JAY, P</au><au>FLYGARE, JOHN, A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTI-VIRAL PYRIMIDINE DERIVATIVES</title><date>1999-08-19</date><risdate>1999</risdate><abstract>Compounds and compositions which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives having formula (I) wherein X is a member selected from the group consisting of -NR R , -OR , -SR , aryl, alkyl and arylalkyl; Y is a member selected from the group consisting of a covalent bond, -N(R )-, -O-, -S-, -C(=O)- and alkylene; R and R are members independently selected from the group consisting of hydrogen, alkyl, -O-alkyl, -S-alkyl, aryl, arylalkyl, -O-aryl, -S-aryl, -NO2, -NR R , -C(O)R , -CO2R , -C(O)NR R , -N(R )C(O)R , -N(R )CO2R , -N(R )C(O)NR R , -S(O)mNR R , -S(O)nR , -CN, halogen, and -N(R )S(O)mR .
L'invention concerne des composés et des compositions convenant au traitement d'infections virales, et en particulier, chez l'homme, l'infection par Cytomégalovirus. Ces composés contiennent les dérivés à base de pyrimidine de l'invention, représentés par la formule générale (I). Dans cette formule, X appartient au groupe des -NR R , -OR , -SR , aryle, alkyle et arylalkyle; Y appartient au group constitué d'une liaison covalente, des -N(R )-, -O-, -S-, -C(=O)-, et de l'alkylène; R et R appartiennent chacun indépendamment au groupe des hydrogène, alkyle, -O-alkyle, -S-alkyle, aryle, arylalkyle, -O-aryle, -S-aryle, -NO2, -NR R , -C(O)R , -CO2R , -C(O)NR R , -N(R )C(O)R , -N(R )CO2R , -N(R )C(O)NR R , -S(O)mNR R , -S(O)nR , -CN, halogène, et -N(R )S(O)mR .</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANTI-VIRAL PYRIMIDINE DERIVATIVES |
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