HETEROCYCLIC TOPOISOMERASE POISONS
The invention provides a topoisomerase poison of formula (I) wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a salt thereof, intermediates useful for pre...
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| creator | LAVOIE, EDMOND, J LIU, LEROY, FONG KIM, JUNG, SUN RANGARAJAN, MEERA |
| description | The invention provides a topoisomerase poison of formula (I) wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a salt thereof, intermediates useful for preparing a compound of formula (I), and therapeutic methods comprising administering a compound of formula (I) or a salt thereof.
L'invention concerne un poison topoisomérase de la formule (I) dans laquelle R1-R8 ont n'importe laquelle des significations définies dans la description, ou alors un sel de ce poison acceptable du point de vue pharmaceutique; l'invention concerne également des compositions pharmaceutiques comprenant un composé de la formule (I) ou un sel de ce composé, des intermédiaires utiles dans la préparation d'un composé de la formule (I) et des méthodes thérapeutiques comprenant l'administration d'un composé de la formule (I) ou d'un sel de ce composé. |
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L'invention concerne un poison topoisomérase de la formule (I) dans laquelle R1-R8 ont n'importe laquelle des significations définies dans la description, ou alors un sel de ce poison acceptable du point de vue pharmaceutique; l'invention concerne également des compositions pharmaceutiques comprenant un composé de la formule (I) ou un sel de ce composé, des intermédiaires utiles dans la préparation d'un composé de la formule (I) et des méthodes thérapeutiques comprenant l'administration d'un composé de la formule (I) ou d'un sel de ce composé.</description><edition>6</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990819&DB=EPODOC&CC=WO&NR=9941241A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990819&DB=EPODOC&CC=WO&NR=9941241A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LAVOIE, EDMOND, J</creatorcontrib><creatorcontrib>LIU, LEROY, FONG</creatorcontrib><creatorcontrib>KIM, JUNG, SUN</creatorcontrib><creatorcontrib>RANGARAJAN, MEERA</creatorcontrib><title>HETEROCYCLIC TOPOISOMERASE POISONS</title><description>The invention provides a topoisomerase poison of formula (I) wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a salt thereof, intermediates useful for preparing a compound of formula (I), and therapeutic methods comprising administering a compound of formula (I) or a salt thereof.
L'invention concerne un poison topoisomérase de la formule (I) dans laquelle R1-R8 ont n'importe laquelle des significations définies dans la description, ou alors un sel de ce poison acceptable du point de vue pharmaceutique; l'invention concerne également des compositions pharmaceutiques comprenant un composé de la formule (I) ou un sel de ce composé, des intermédiaires utiles dans la préparation d'un composé de la formule (I) et des méthodes thérapeutiques comprenant l'administration d'un composé de la formule (I) ou d'un sel de ce composé.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFDycA1xDfJ3jnT28XRWCPEP8PcM9vd1DXIMdlUAs_2CeRhY0xJzilN5oTQ3g4Kba4izh25qQX58anFBYnJqXmpJfLi_paWJoZGJoaOhMRFKACeIIqI</recordid><startdate>19990819</startdate><enddate>19990819</enddate><creator>LAVOIE, EDMOND, J</creator><creator>LIU, LEROY, FONG</creator><creator>KIM, JUNG, SUN</creator><creator>RANGARAJAN, MEERA</creator><scope>EVB</scope></search><sort><creationdate>19990819</creationdate><title>HETEROCYCLIC TOPOISOMERASE POISONS</title><author>LAVOIE, EDMOND, J ; LIU, LEROY, FONG ; KIM, JUNG, SUN ; RANGARAJAN, MEERA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9941241A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1999</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LAVOIE, EDMOND, J</creatorcontrib><creatorcontrib>LIU, LEROY, FONG</creatorcontrib><creatorcontrib>KIM, JUNG, SUN</creatorcontrib><creatorcontrib>RANGARAJAN, MEERA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LAVOIE, EDMOND, J</au><au>LIU, LEROY, FONG</au><au>KIM, JUNG, SUN</au><au>RANGARAJAN, MEERA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HETEROCYCLIC TOPOISOMERASE POISONS</title><date>1999-08-19</date><risdate>1999</risdate><abstract>The invention provides a topoisomerase poison of formula (I) wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a salt thereof, intermediates useful for preparing a compound of formula (I), and therapeutic methods comprising administering a compound of formula (I) or a salt thereof.
L'invention concerne un poison topoisomérase de la formule (I) dans laquelle R1-R8 ont n'importe laquelle des significations définies dans la description, ou alors un sel de ce poison acceptable du point de vue pharmaceutique; l'invention concerne également des compositions pharmaceutiques comprenant un composé de la formule (I) ou un sel de ce composé, des intermédiaires utiles dans la préparation d'un composé de la formule (I) et des méthodes thérapeutiques comprenant l'administration d'un composé de la formule (I) ou d'un sel de ce composé.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HETEROCYCLIC TOPOISOMERASE POISONS |
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