PAI-2 AND t-PA AS DIAGNOSTIC MARKERS OF PERIODONTAL DISEASE

The existence and the extent of periodontal disease can be diagnosed by measuring plasminogen activator inhibitor 2 (PAI-2) and/or tissue plasminogen activator (t-PA) levels in gingival crevicular fluid (GCF). Levels of PAI-2 and t-PA in GCF rise sharply in the context of periodontal disease, and th...

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Bibliographische Detailangaben
Hauptverfasser:	XIAO, YIN, BARTOLD, PETER, M, BUNN, CLIVE, L
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The existence and the extent of periodontal disease can be diagnosed by measuring plasminogen activator inhibitor 2 (PAI-2) and/or tissue plasminogen activator (t-PA) levels in gingival crevicular fluid (GCF). Levels of PAI-2 and t-PA in GCF rise sharply in the context of periodontal disease, and they also correlate with the severity of disease at different sites in the same patient. Selon cette invention, il est possible de diagnostiquer l'existence et l'étendue de la parodontopathie en mesurant les taux d'inhibiteurs 2 (PAI-2) de l'activateur du plasminogène et/ou de l'activateur (t-PA) du plasminogène de type tissulaire dans le fluide gingival. L'augmentation brusque des taux de PAI-2 et t-PA dans le fluide gingival indiquent la présence de la parodontopathie, ces taux ayant également une corrélation avec la gravité de la maladie au niveau de différents sites chez le même patient.