TRANSGENIC ANIMAL MODEL FOR DEGENERATIVE DISEASES OF CARTILAGE
The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also p...
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| creator | NEUHOLD, LISA, ANN KILLAR, LORAN, MARIE |
| description | The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides.
L'invention concerne des systèmes modèles animaux de lutte contre une maladie dégénérative du cartilage. Ces systèmes modèles comprennent des animaux transgéniques pouvant exprimer des enzymes recombinantes d'altération matricielle (MDE), en particulier des métalloprotéases matricielles (MMP), par régulation temporelle et spatiale. L'invention concerne également des procédés de production d'indicateurs phénotypiques d'une maladie dégénérative du cartilage chez un mammifère, et des procédés pour déterminer le pouvoir d'une composition de lutter contre une maladie dégénérative du cartilage. L'invention concerne enfin des acides nucléiques isolés codant des polypeptides proMMP présentant une activité enzymatique constitutive et des polypeptides proMMP isolés. |
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L'invention concerne des systèmes modèles animaux de lutte contre une maladie dégénérative du cartilage. Ces systèmes modèles comprennent des animaux transgéniques pouvant exprimer des enzymes recombinantes d'altération matricielle (MDE), en particulier des métalloprotéases matricielles (MMP), par régulation temporelle et spatiale. L'invention concerne également des procédés de production d'indicateurs phénotypiques d'une maladie dégénérative du cartilage chez un mammifère, et des procédés pour déterminer le pouvoir d'une composition de lutter contre une maladie dégénérative du cartilage. L'invention concerne enfin des acides nucléiques isolés codant des polypeptides proMMP présentant une activité enzymatique constitutive et des polypeptides proMMP isolés.</description><edition>6</edition><language>eng ; fre</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BEER ; BIOCHEMISTRY ; CARE OF BIRDS, FISHES, INSECTS ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NEW BREEDS OF ANIMALS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TRAPPING ; VINEGAR ; WINE</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990701&DB=EPODOC&CC=WO&NR=9931969A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990701&DB=EPODOC&CC=WO&NR=9931969A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NEUHOLD, LISA, ANN</creatorcontrib><creatorcontrib>KILLAR, LORAN, MARIE</creatorcontrib><title>TRANSGENIC ANIMAL MODEL FOR DEGENERATIVE DISEASES OF CARTILAGE</title><description>The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides.
L'invention concerne des systèmes modèles animaux de lutte contre une maladie dégénérative du cartilage. Ces systèmes modèles comprennent des animaux transgéniques pouvant exprimer des enzymes recombinantes d'altération matricielle (MDE), en particulier des métalloprotéases matricielles (MMP), par régulation temporelle et spatiale. L'invention concerne également des procédés de production d'indicateurs phénotypiques d'une maladie dégénérative du cartilage chez un mammifère, et des procédés pour déterminer le pouvoir d'une composition de lutter contre une maladie dégénérative du cartilage. L'invention concerne enfin des acides nucléiques isolés codant des polypeptides proMMP présentant une activité enzymatique constitutive et des polypeptides proMMP isolés.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CARE OF BIRDS, FISHES, INSECTS</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NEW BREEDS OF ANIMALS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TRAPPING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLALCXL0C3Z39fN0VnD08_R19FHw9Xdx9VFw8w9ScHEFSrgGOYZ4hrkquHgGuzoGuwYr-LspODsGhXj6OLq78jCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSS-HB_S0tjQ0szS0cjYyKUAAD4winK</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>NEUHOLD, LISA, ANN</creator><creator>KILLAR, LORAN, MARIE</creator><scope>EVB</scope></search><sort><creationdate>19990701</creationdate><title>TRANSGENIC ANIMAL MODEL FOR DEGENERATIVE DISEASES OF CARTILAGE</title><author>NEUHOLD, LISA, ANN ; KILLAR, LORAN, MARIE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9931969A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1999</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CARE OF BIRDS, FISHES, INSECTS</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NEW BREEDS OF ANIMALS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TRAPPING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>NEUHOLD, LISA, ANN</creatorcontrib><creatorcontrib>KILLAR, LORAN, MARIE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NEUHOLD, LISA, ANN</au><au>KILLAR, LORAN, MARIE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRANSGENIC ANIMAL MODEL FOR DEGENERATIVE DISEASES OF CARTILAGE</title><date>1999-07-01</date><risdate>1999</risdate><abstract>The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides.
L'invention concerne des systèmes modèles animaux de lutte contre une maladie dégénérative du cartilage. Ces systèmes modèles comprennent des animaux transgéniques pouvant exprimer des enzymes recombinantes d'altération matricielle (MDE), en particulier des métalloprotéases matricielles (MMP), par régulation temporelle et spatiale. L'invention concerne également des procédés de production d'indicateurs phénotypiques d'une maladie dégénérative du cartilage chez un mammifère, et des procédés pour déterminer le pouvoir d'une composition de lutter contre une maladie dégénérative du cartilage. L'invention concerne enfin des acides nucléiques isolés codant des polypeptides proMMP présentant une activité enzymatique constitutive et des polypeptides proMMP isolés.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRAPPING VINEGAR WINE |
| title | TRANSGENIC ANIMAL MODEL FOR DEGENERATIVE DISEASES OF CARTILAGE |
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