A POLYPEPTIDES INHIBITING BINDING BETWEEN BONE SIALOPROTEIN ANS STAPHYLOCOCCAL CELLS
A polypeptide of bone sialoprotein selected from an amino acid sequence within position 42 to position 85 in the amino acid sequence set forth in SEQ ID NO: 10 and comprising the amino acid sequence LKRF, said polypeptide having the ability to inhibit the binding of bone sialoprotein to staphylococc...
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| creator | RYDEN, CECILIA OLDBERG, AAKE |
| description | A polypeptide of bone sialoprotein selected from an amino acid sequence within position 42 to position 85 in the amino acid sequence set forth in SEQ ID NO: 10 and comprising the amino acid sequence LKRF, said polypeptide having the ability to inhibit the binding of bone sialoprotein to staphylococcal cells, or functional equivalents comprising the sequence LKRF. The invention also comprises the polypeptide for use as a medicament and use of the polypeptide for the manufacture of a medicament for inhibiting staphylococcal adhesion to tissues or implants. Further a method of inhibiting staphylococcal adhesion to tissues or implants of a mammal, including man, is included.
L'invention concerne un polypeptide d'une sialoprotéine osseuse sélectionnée dans une séquence d'acides aminés de la position 42 à la position 85 de la séquence d'acides aminés donnée dans SEQ ID NO: 10 et comprenant la séquence d'acides aminés LKRF. Ce polypeptide à l'aptitude d'inhiber la liaison entre la sialoprotéine osseuse et les cellules staphylococciques ou équivalents fonctionnels comprenant la séquence LKRF. L'invention comprend également le polypeptide destiné à être utilisé comme médicament et l'utilisation du polypeptide pour la production d'un médicament inhibant l'adhésion staphylococcique aux tissus et implants. L'invention comprend enfin un procédé inhibant l'adhésion staphylococcique aux tissus ou implants chez un mammifère, y compris chez l'homme. |
| format | Patent |
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L'invention concerne un polypeptide d'une sialoprotéine osseuse sélectionnée dans une séquence d'acides aminés de la position 42 à la position 85 de la séquence d'acides aminés donnée dans SEQ ID NO: 10 et comprenant la séquence d'acides aminés LKRF. Ce polypeptide à l'aptitude d'inhiber la liaison entre la sialoprotéine osseuse et les cellules staphylococciques ou équivalents fonctionnels comprenant la séquence LKRF. L'invention comprend également le polypeptide destiné à être utilisé comme médicament et l'utilisation du polypeptide pour la production d'un médicament inhibant l'adhésion staphylococcique aux tissus et implants. L'invention comprend enfin un procédé inhibant l'adhésion staphylococcique aux tissus ou implants chez un mammifère, y compris chez l'homme.</description><edition>6</edition><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990408&DB=EPODOC&CC=WO&NR=9916792A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990408&DB=EPODOC&CC=WO&NR=9916792A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RYDEN, CECILIA</creatorcontrib><creatorcontrib>OLDBERG, AAKE</creatorcontrib><title>A POLYPEPTIDES INHIBITING BINDING BETWEEN BONE SIALOPROTEIN ANS STAPHYLOCOCCAL CELLS</title><description>A polypeptide of bone sialoprotein selected from an amino acid sequence within position 42 to position 85 in the amino acid sequence set forth in SEQ ID NO: 10 and comprising the amino acid sequence LKRF, said polypeptide having the ability to inhibit the binding of bone sialoprotein to staphylococcal cells, or functional equivalents comprising the sequence LKRF. The invention also comprises the polypeptide for use as a medicament and use of the polypeptide for the manufacture of a medicament for inhibiting staphylococcal adhesion to tissues or implants. Further a method of inhibiting staphylococcal adhesion to tissues or implants of a mammal, including man, is included.
L'invention concerne un polypeptide d'une sialoprotéine osseuse sélectionnée dans une séquence d'acides aminés de la position 42 à la position 85 de la séquence d'acides aminés donnée dans SEQ ID NO: 10 et comprenant la séquence d'acides aminés LKRF. Ce polypeptide à l'aptitude d'inhiber la liaison entre la sialoprotéine osseuse et les cellules staphylococciques ou équivalents fonctionnels comprenant la séquence LKRF. L'invention comprend également le polypeptide destiné à être utilisé comme médicament et l'utilisation du polypeptide pour la production d'un médicament inhibant l'adhésion staphylococcique aux tissus et implants. L'invention comprend enfin un procédé inhibant l'adhésion staphylococcique aux tissus ou implants chez un mammifère, y compris chez l'homme.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQANAsDqL-w_2AQxWUjEl6moNwF8xB6VRKiZNoof4_gvgBTm95a6MOsqQ-Y1ZqsQBxJE9KfAVP3H5F7RAZvDBCIZck30SRGBwXKOpy7JMECcElCJhS2ZrVfXwsdfdzY-CCGuK-zq-hLvM41Wd9D51Y25zO9uCa4x_lA_J6MDM</recordid><startdate>19990408</startdate><enddate>19990408</enddate><creator>RYDEN, CECILIA</creator><creator>OLDBERG, AAKE</creator><scope>EVB</scope></search><sort><creationdate>19990408</creationdate><title>A POLYPEPTIDES INHIBITING BINDING BETWEEN BONE SIALOPROTEIN ANS STAPHYLOCOCCAL CELLS</title><author>RYDEN, CECILIA ; OLDBERG, AAKE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9916792A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1999</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>RYDEN, CECILIA</creatorcontrib><creatorcontrib>OLDBERG, AAKE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RYDEN, CECILIA</au><au>OLDBERG, AAKE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A POLYPEPTIDES INHIBITING BINDING BETWEEN BONE SIALOPROTEIN ANS STAPHYLOCOCCAL CELLS</title><date>1999-04-08</date><risdate>1999</risdate><abstract>A polypeptide of bone sialoprotein selected from an amino acid sequence within position 42 to position 85 in the amino acid sequence set forth in SEQ ID NO: 10 and comprising the amino acid sequence LKRF, said polypeptide having the ability to inhibit the binding of bone sialoprotein to staphylococcal cells, or functional equivalents comprising the sequence LKRF. The invention also comprises the polypeptide for use as a medicament and use of the polypeptide for the manufacture of a medicament for inhibiting staphylococcal adhesion to tissues or implants. Further a method of inhibiting staphylococcal adhesion to tissues or implants of a mammal, including man, is included.
L'invention concerne un polypeptide d'une sialoprotéine osseuse sélectionnée dans une séquence d'acides aminés de la position 42 à la position 85 de la séquence d'acides aminés donnée dans SEQ ID NO: 10 et comprenant la séquence d'acides aminés LKRF. Ce polypeptide à l'aptitude d'inhiber la liaison entre la sialoprotéine osseuse et les cellules staphylococciques ou équivalents fonctionnels comprenant la séquence LKRF. L'invention comprend également le polypeptide destiné à être utilisé comme médicament et l'utilisation du polypeptide pour la production d'un médicament inhibant l'adhésion staphylococcique aux tissus et implants. L'invention comprend enfin un procédé inhibant l'adhésion staphylococcique aux tissus ou implants chez un mammifère, y compris chez l'homme.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | A POLYPEPTIDES INHIBITING BINDING BETWEEN BONE SIALOPROTEIN ANS STAPHYLOCOCCAL CELLS |
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