DIHYDROPYRIDINE NPY ANTAGONISTS: CYANOGUANIDINE DERIVATIVES
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight...
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| creator | POINDEXTER, GRAHAM, S SWANN, R., THOMAS BRUCE, MARC, A BREITENBUCHER, JAMES, G MORTON, MENDI, A SIT, SING-YUEN HUANG, YAZHONG |
| description | A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.
L'invention concerne une série d'antagonistes non peptidergiques de NPY qui ont été synthétisés, et qui sont constitués de dérivés de cyanoguanidine de 4-phényl-1,4-dihydropyridines représentés par la formule (I). Comme antagonistes de comportements alimentaires provoqués par NPY, ces composés agissent comme des agents anorexigènes efficaces en activant une perte de poids et en permettant de traiter des troubles de l'alimentation. |
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L'invention concerne une série d'antagonistes non peptidergiques de NPY qui ont été synthétisés, et qui sont constitués de dérivés de cyanoguanidine de 4-phényl-1,4-dihydropyridines représentés par la formule (I). Comme antagonistes de comportements alimentaires provoqués par NPY, ces composés agissent comme des agents anorexigènes efficaces en activant une perte de poids et en permettant de traiter des troubles de l'alimentation.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| title | DIHYDROPYRIDINE NPY ANTAGONISTS: CYANOGUANIDINE DERIVATIVES |
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