INHIBITIONS OF THE INTERACTION BETWEEN P53 AND MDM2
The present invention relates to compounds capable of binding to the oncogene protein MDM2, processes for the preparation of such compounds, pharmaceutical preparations comprising such compounds, and uses of said compounds, e.g. in the therapeutic (including prophylactic) treatment of an animal or e...
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| creator | HOCHKEPPEL, HEINZ-KURT BOETTGER, ANGELIKA PICKSLEY, STEPHEN CHENE, PATRICK BOETTGER, VOLKER FURET, PASCAL GARCIA-ECHEVERRIA, CARLOS LANE, DAVID |
| description | The present invention relates to compounds capable of binding to the oncogene protein MDM2, processes for the preparation of such compounds, pharmaceutical preparations comprising such compounds, and uses of said compounds, e.g. in the therapeutic (including prophylactic) treatment of an animal or especially of the human body. The present further relates to methods of and compounds for inhibiting the growth of tumor cells which comprise the wild type p53 suppressor by interfering with the interaction between human p53 and human MDM2.
Composés capables de se lier à la protéine oncogène MDM2, procédés pour préparer ces composants, préparations pharmaceutiques contenant de tels composants et utilisations de ces composants, par exemple dans le traitement thérapeutique (y compris préventif) d'un animal ou plus particulièrement de l'organisme humain. L'invention porte également sur des méthodes et des composants pour inhiber la croissance des cellules tumorales contenant le gène suppresseur p53 de type sauvage, en inhibant l'interaction entre le gène p53 humain et la protéine MDM2 humaine. |
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Composés capables de se lier à la protéine oncogène MDM2, procédés pour préparer ces composants, préparations pharmaceutiques contenant de tels composants et utilisations de ces composants, par exemple dans le traitement thérapeutique (y compris préventif) d'un animal ou plus particulièrement de l'organisme humain. L'invention porte également sur des méthodes et des composants pour inhiber la croissance des cellules tumorales contenant le gène suppresseur p53 de type sauvage, en inhibant l'interaction entre le gène p53 humain et la protéine MDM2 humaine.</description><edition>6</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980115&DB=EPODOC&CC=WO&NR=9801467A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980115&DB=EPODOC&CC=WO&NR=9801467A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HOCHKEPPEL, HEINZ-KURT</creatorcontrib><creatorcontrib>BOETTGER, ANGELIKA</creatorcontrib><creatorcontrib>PICKSLEY, STEPHEN</creatorcontrib><creatorcontrib>CHENE, PATRICK</creatorcontrib><creatorcontrib>BOETTGER, VOLKER</creatorcontrib><creatorcontrib>FURET, PASCAL</creatorcontrib><creatorcontrib>GARCIA-ECHEVERRIA, CARLOS</creatorcontrib><creatorcontrib>LANE, DAVID</creatorcontrib><title>INHIBITIONS OF THE INTERACTION BETWEEN P53 AND MDM2</title><description>The present invention relates to compounds capable of binding to the oncogene protein MDM2, processes for the preparation of such compounds, pharmaceutical preparations comprising such compounds, and uses of said compounds, e.g. in the therapeutic (including prophylactic) treatment of an animal or especially of the human body. The present further relates to methods of and compounds for inhibiting the growth of tumor cells which comprise the wild type p53 suppressor by interfering with the interaction between human p53 and human MDM2.
Composés capables de se lier à la protéine oncogène MDM2, procédés pour préparer ces composants, préparations pharmaceutiques contenant de tels composants et utilisations de ces composants, par exemple dans le traitement thérapeutique (y compris préventif) d'un animal ou plus particulièrement de l'organisme humain. L'invention porte également sur des méthodes et des composants pour inhiber la croissance des cellules tumorales contenant le gène suppresseur p53 de type sauvage, en inhibant l'interaction entre le gène p53 humain et la protéine MDM2 humaine.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1998</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDD29PPwdPIM8fT3C1bwd1MI8XBV8PQLcQ1ydAaJKTi5hoS7uvopBJgaKzj6uSj4uvga8TCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSS-HB_SwsDQxMzc0cjYyKUAAAsxiZn</recordid><startdate>19980115</startdate><enddate>19980115</enddate><creator>HOCHKEPPEL, HEINZ-KURT</creator><creator>BOETTGER, ANGELIKA</creator><creator>PICKSLEY, STEPHEN</creator><creator>CHENE, PATRICK</creator><creator>BOETTGER, VOLKER</creator><creator>FURET, PASCAL</creator><creator>GARCIA-ECHEVERRIA, CARLOS</creator><creator>LANE, DAVID</creator><scope>EVB</scope></search><sort><creationdate>19980115</creationdate><title>INHIBITIONS OF THE INTERACTION BETWEEN P53 AND MDM2</title><author>HOCHKEPPEL, HEINZ-KURT ; BOETTGER, ANGELIKA ; PICKSLEY, STEPHEN ; CHENE, PATRICK ; BOETTGER, VOLKER ; FURET, PASCAL ; GARCIA-ECHEVERRIA, CARLOS ; LANE, DAVID</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9801467A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1998</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>HOCHKEPPEL, HEINZ-KURT</creatorcontrib><creatorcontrib>BOETTGER, ANGELIKA</creatorcontrib><creatorcontrib>PICKSLEY, STEPHEN</creatorcontrib><creatorcontrib>CHENE, PATRICK</creatorcontrib><creatorcontrib>BOETTGER, VOLKER</creatorcontrib><creatorcontrib>FURET, PASCAL</creatorcontrib><creatorcontrib>GARCIA-ECHEVERRIA, CARLOS</creatorcontrib><creatorcontrib>LANE, DAVID</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HOCHKEPPEL, HEINZ-KURT</au><au>BOETTGER, ANGELIKA</au><au>PICKSLEY, STEPHEN</au><au>CHENE, PATRICK</au><au>BOETTGER, VOLKER</au><au>FURET, PASCAL</au><au>GARCIA-ECHEVERRIA, CARLOS</au><au>LANE, DAVID</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INHIBITIONS OF THE INTERACTION BETWEEN P53 AND MDM2</title><date>1998-01-15</date><risdate>1998</risdate><abstract>The present invention relates to compounds capable of binding to the oncogene protein MDM2, processes for the preparation of such compounds, pharmaceutical preparations comprising such compounds, and uses of said compounds, e.g. in the therapeutic (including prophylactic) treatment of an animal or especially of the human body. The present further relates to methods of and compounds for inhibiting the growth of tumor cells which comprise the wild type p53 suppressor by interfering with the interaction between human p53 and human MDM2.
Composés capables de se lier à la protéine oncogène MDM2, procédés pour préparer ces composants, préparations pharmaceutiques contenant de tels composants et utilisations de ces composants, par exemple dans le traitement thérapeutique (y compris préventif) d'un animal ou plus particulièrement de l'organisme humain. L'invention porte également sur des méthodes et des composants pour inhiber la croissance des cellules tumorales contenant le gène suppresseur p53 de type sauvage, en inhibant l'interaction entre le gène p53 humain et la protéine MDM2 humaine.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | INHIBITIONS OF THE INTERACTION BETWEEN P53 AND MDM2 |
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