TRICYCLIC IBOGAINE ANALOGS, THEIR PREPARATION AND THEIR USE IN TREATING SUBSTANCE ABUSE
The present invention provides a series of ibogaine analogs of formula (I) wherein: R1 is S or O; R2 is H, (C1-C4)alkyl, (C1-C4)alkoxy, OH, CN, CONH2, halo, oxazolyl, (C1-C4)alkylS, or (C1-C2)trifluoroalkyl; R3 is a phenyl group optionally substituted at the 2'- or 3'-position of the pheny...
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| creator | EFANGE, S., MBUA, NGALE MASH, DEBORAH, CARMEN |
| description | The present invention provides a series of ibogaine analogs of formula (I) wherein: R1 is S or O; R2 is H, (C1-C4)alkyl, (C1-C4)alkoxy, OH, CN, CONH2, halo, oxazolyl, (C1-C4)alkylS, or (C1-C2)trifluoroalkyl; R3 is a phenyl group optionally substituted at the 2'- or 3'-position of the phenyl ring with halo, N(R)2, wherein each R is H or (C1-C4)alkyl; or NO2; and R4 is (C3-C6)cycloalkyl(C1-C4)alkyl, (C3-C6)cycloalkyl or (C1-C4)alkyl, optionally containing 1-2 double bonds, and the pharmaceutically acceptable salts thereof, useful to treat cocaine addiction and the use of other addictive substances.
Série d'analogues d'ibogaïne de formule (I) dans laquelle R1 est S ou O; R2 est H, alkyle (C1-C4), alcoxy (C1-C4), OH, CN, CONH2, halo, oxazolyle, alkyls (C1-C4) ou trifluoroalkyle (C1-C2); R3 est un groupe phényle éventuellement substitué en position 2' ou 3' du cycle phényle avec halo, N(R)2, chaque R étant H ou alkyle (C1-C4); ou NO2; et R4 est cycloalkyle (C3-C6)-alkyle (C1-C4), cycloalkyle (C3-C6) ou alkyle (C1-C4), contenant éventuellement 1 ou 2 liaisons doubles, ainsi que sels pharmaceutiquement acceptables desdits analogues, utiles pour traiter la dépendance à la cocaïne et l'utilisation d'autres substances créant l'accoutumance. |
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Série d'analogues d'ibogaïne de formule (I) dans laquelle R1 est S ou O; R2 est H, alkyle (C1-C4), alcoxy (C1-C4), OH, CN, CONH2, halo, oxazolyle, alkyls (C1-C4) ou trifluoroalkyle (C1-C2); R3 est un groupe phényle éventuellement substitué en position 2' ou 3' du cycle phényle avec halo, N(R)2, chaque R étant H ou alkyle (C1-C4); ou NO2; et R4 est cycloalkyle (C3-C6)-alkyle (C1-C4), cycloalkyle (C3-C6) ou alkyle (C1-C4), contenant éventuellement 1 ou 2 liaisons doubles, ainsi que sels pharmaceutiquement acceptables desdits analogues, utiles pour traiter la dépendance à la cocaïne et l'utilisation d'autres substances créant l'accoutumance.</description><edition>6</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1997</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970612&DB=EPODOC&CC=WO&NR=9720847A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970612&DB=EPODOC&CC=WO&NR=9720847A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>EFANGE, S., MBUA, NGALE</creatorcontrib><creatorcontrib>MASH, DEBORAH, CARMEN</creatorcontrib><title>TRICYCLIC IBOGAINE ANALOGS, THEIR PREPARATION AND THEIR USE IN TREATING SUBSTANCE ABUSE</title><description>The present invention provides a series of ibogaine analogs of formula (I) wherein: R1 is S or O; R2 is H, (C1-C4)alkyl, (C1-C4)alkoxy, OH, CN, CONH2, halo, oxazolyl, (C1-C4)alkylS, or (C1-C2)trifluoroalkyl; R3 is a phenyl group optionally substituted at the 2'- or 3'-position of the phenyl ring with halo, N(R)2, wherein each R is H or (C1-C4)alkyl; or NO2; and R4 is (C3-C6)cycloalkyl(C1-C4)alkyl, (C3-C6)cycloalkyl or (C1-C4)alkyl, optionally containing 1-2 double bonds, and the pharmaceutically acceptable salts thereof, useful to treat cocaine addiction and the use of other addictive substances.
Série d'analogues d'ibogaïne de formule (I) dans laquelle R1 est S ou O; R2 est H, alkyle (C1-C4), alcoxy (C1-C4), OH, CN, CONH2, halo, oxazolyle, alkyls (C1-C4) ou trifluoroalkyle (C1-C2); R3 est un groupe phényle éventuellement substitué en position 2' ou 3' du cycle phényle avec halo, N(R)2, chaque R étant H ou alkyle (C1-C4); ou NO2; et R4 est cycloalkyle (C3-C6)-alkyle (C1-C4), cycloalkyle (C3-C6) ou alkyle (C1-C4), contenant éventuellement 1 ou 2 liaisons doubles, ainsi que sels pharmaceutiquement acceptables desdits analogues, utiles pour traiter la dépendance à la cocaïne et l'utilisation d'autres substances créant l'accoutumance.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1997</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAgPCfJ0jnT28XRW8HTyd3f09HNVcPRz9PF3D9ZRCPFw9QxSCAhyDXAMcgzx9PcDSrlARUODXRU8_RRCglyBMn7uCsGhTsEhjn7OQO1OQDkeBta0xJziVF4ozc2g4OYa4uyhm1qQH59aXJCYnJqXWhIf7m9pbmRgYWLuaGhMhBIATbMwkQ</recordid><startdate>19970612</startdate><enddate>19970612</enddate><creator>EFANGE, S., MBUA, NGALE</creator><creator>MASH, DEBORAH, CARMEN</creator><scope>EVB</scope></search><sort><creationdate>19970612</creationdate><title>TRICYCLIC IBOGAINE ANALOGS, THEIR PREPARATION AND THEIR USE IN TREATING SUBSTANCE ABUSE</title><author>EFANGE, S., MBUA, NGALE ; MASH, DEBORAH, CARMEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9720847A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1997</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>EFANGE, S., MBUA, NGALE</creatorcontrib><creatorcontrib>MASH, DEBORAH, CARMEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>EFANGE, S., MBUA, NGALE</au><au>MASH, DEBORAH, CARMEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRICYCLIC IBOGAINE ANALOGS, THEIR PREPARATION AND THEIR USE IN TREATING SUBSTANCE ABUSE</title><date>1997-06-12</date><risdate>1997</risdate><abstract>The present invention provides a series of ibogaine analogs of formula (I) wherein: R1 is S or O; R2 is H, (C1-C4)alkyl, (C1-C4)alkoxy, OH, CN, CONH2, halo, oxazolyl, (C1-C4)alkylS, or (C1-C2)trifluoroalkyl; R3 is a phenyl group optionally substituted at the 2'- or 3'-position of the phenyl ring with halo, N(R)2, wherein each R is H or (C1-C4)alkyl; or NO2; and R4 is (C3-C6)cycloalkyl(C1-C4)alkyl, (C3-C6)cycloalkyl or (C1-C4)alkyl, optionally containing 1-2 double bonds, and the pharmaceutically acceptable salts thereof, useful to treat cocaine addiction and the use of other addictive substances.
Série d'analogues d'ibogaïne de formule (I) dans laquelle R1 est S ou O; R2 est H, alkyle (C1-C4), alcoxy (C1-C4), OH, CN, CONH2, halo, oxazolyle, alkyls (C1-C4) ou trifluoroalkyle (C1-C2); R3 est un groupe phényle éventuellement substitué en position 2' ou 3' du cycle phényle avec halo, N(R)2, chaque R étant H ou alkyle (C1-C4); ou NO2; et R4 est cycloalkyle (C3-C6)-alkyle (C1-C4), cycloalkyle (C3-C6) ou alkyle (C1-C4), contenant éventuellement 1 ou 2 liaisons doubles, ainsi que sels pharmaceutiquement acceptables desdits analogues, utiles pour traiter la dépendance à la cocaïne et l'utilisation d'autres substances créant l'accoutumance.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | TRICYCLIC IBOGAINE ANALOGS, THEIR PREPARATION AND THEIR USE IN TREATING SUBSTANCE ABUSE |
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