CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Novel amino acid analogs are provided having the formula (I): Z-A3-A2-A1-Q, wherein Z is H or a protecting group; A3 and A2 are independently an optionally protected valine, leucine, alanine, isoleucine, phenylalnine, tyrosine, glycine, 2-arylglycine having either D or L stereochemistry or a chemica...

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Bibliographische Detailangaben
Hauptverfasser:	DOLLE, ROLAND, E, MILLER, MATTHEW, S, OSIFO, IRENNEGBE, K, HARRIS, ALEX, L, GRAYBILL, TODD, L
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	Novel amino acid analogs are provided having the formula (I): Z-A3-A2-A1-Q, wherein Z is H or a protecting group; A3 and A2 are independently an optionally protected valine, leucine, alanine, isoleucine, phenylalnine, tyrosine, glycine, 2-arylglycine having either D or L stereochemistry or a chemical bond; A1 is an optionally protected valine, leucine, isoleucine, alanine, phenylalnine, tyrosine, 2-phenyl-glycine, 2-phenethyl-glycine, 2-aryl-glycine; Q is H, CH2OCOL, CH2OL, CH2SL, CH2X, NHNHCOCH2OCOL, NHNHCOCH2OL, NHNHCOCH2SL, wherein L is an optionally substituted aryl or optionally substituted hereroaryl; and X is CI, Br or F, and a pharmaceutically acceptable salt thereof. L'invention concerne de nouveaux analogues d'acides aminés, et un de leurs sels pharmacologiquement acceptable, de formule (I): Z-A3-A2-A1-Q, dans laquelle Z représente H ou un groupe de protection; A3 et A2 représentent indépendemment valine, leucine, alanine, isoleucine, phénylalnine, tyrosine, glycine, 2-arylglycine, toutes éventuellement protégées, et présentant une stéréochimie D ou L ou une liaison chimique; A1 représente valine, leucine, isoleucine, alanine, phénylalnine, tyrosine, 2-phényl-glycine, 2-phénéthyl-glycine, 2-aryl-glycine, toutes éventuellement protégées; Q représente H, CH2OCOL, CH2OL, CH2SL, CH2X, NHNHCOCH2OCOL, NHNHCOCH2OL, NHNHCOCH2SL, où L représente aryle ou hétéroaryle éventuellement substitués; et X représente CI, Br ou F.