COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF EFFECTOR MOLECULES
Targeting and effector molecules are conjugated by covalent attachment of the targeting molecule to the effector molecule by a combination of imine formation and thioalkylation. The conjugates are used in therapeutic or diagnostic applications to target the effector molecule to a desired cell or tis...
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| description | Targeting and effector molecules are conjugated by covalent attachment of the targeting molecule to the effector molecule by a combination of imine formation and thioalkylation. The conjugates are used in therapeutic or diagnostic applications to target the effector molecule to a desired cell or tissue. The immunoconjugates are particularly useful in the treatment of tumors, where, for example, antibody-doxorubicin conjugates are effective against doxorubicin resistant tumor cells.
Des molécules de ciblage et effectrices sont conjuguées par fixation covalente de la molécule de ciblage à la molécule effectrice par une combinaison de formation d'imine et de thioalkylation. Les conjugués s'utilisent, dans des applications thérapeutiques ou diagnostiques, pour diriger la molécule effectrice vers une cellule ou un tissu désiré. Les immunoconjugués sont particulièrement utiles dans le traitement de tumeurs, là où, par exemple, les conjugués anticorps-doxorubicine sont efficaces contre les cellules tumorales résistant à la doxorubicine. |
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Des molécules de ciblage et effectrices sont conjuguées par fixation covalente de la molécule de ciblage à la molécule effectrice par une combinaison de formation d'imine et de thioalkylation. Les conjugués s'utilisent, dans des applications thérapeutiques ou diagnostiques, pour diriger la molécule effectrice vers une cellule ou un tissu désiré. Les immunoconjugués sont particulièrement utiles dans le traitement de tumeurs, là où, par exemple, les conjugués anticorps-doxorubicine sont efficaces contre les cellules tumorales résistant à la doxorubicine.</description><edition>6</edition><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961212&DB=EPODOC&CC=WO&NR=9639183A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961212&DB=EPODOC&CC=WO&NR=9639183A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SIVAM, GOWSALA, P</creatorcontrib><title>COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF EFFECTOR MOLECULES</title><description>Targeting and effector molecules are conjugated by covalent attachment of the targeting molecule to the effector molecule by a combination of imine formation and thioalkylation. The conjugates are used in therapeutic or diagnostic applications to target the effector molecule to a desired cell or tissue. The immunoconjugates are particularly useful in the treatment of tumors, where, for example, antibody-doxorubicin conjugates are effective against doxorubicin resistant tumor cells.
Des molécules de ciblage et effectrices sont conjuguées par fixation covalente de la molécule de ciblage à la molécule effectrice par une combinaison de formation d'imine et de thioalkylation. Les conjugués s'utilisent, dans des applications thérapeutiques ou diagnostiques, pour diriger la molécule effectrice vers une cellule ou un tissu désiré. Les immunoconjugués sont particulièrement utiles dans le traitement de tumeurs, là où, par exemple, les conjugués anticorps-doxorubicine sont efficaces contre les cellules tumorales résistant à la doxorubicine.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBx9vcN8A_2DPH09wtWcPRzUfB1DfHwdwlWcPMPUghxDHJ3DXF1UXBx9fEMcw2KVPB3U3B1c3N1DgHK-vr7uDqH-rgG8zCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSS-HB_SzNjS0MLY0dDYyKUAAAcPiu4</recordid><startdate>19961212</startdate><enddate>19961212</enddate><creator>SIVAM, GOWSALA, P</creator><scope>EVB</scope></search><sort><creationdate>19961212</creationdate><title>COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF EFFECTOR MOLECULES</title><author>SIVAM, GOWSALA, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9639183A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1996</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>SIVAM, GOWSALA, P</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SIVAM, GOWSALA, P</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF EFFECTOR MOLECULES</title><date>1996-12-12</date><risdate>1996</risdate><abstract>Targeting and effector molecules are conjugated by covalent attachment of the targeting molecule to the effector molecule by a combination of imine formation and thioalkylation. The conjugates are used in therapeutic or diagnostic applications to target the effector molecule to a desired cell or tissue. The immunoconjugates are particularly useful in the treatment of tumors, where, for example, antibody-doxorubicin conjugates are effective against doxorubicin resistant tumor cells.
Des molécules de ciblage et effectrices sont conjuguées par fixation covalente de la molécule de ciblage à la molécule effectrice par une combinaison de formation d'imine et de thioalkylation. Les conjugués s'utilisent, dans des applications thérapeutiques ou diagnostiques, pour diriger la molécule effectrice vers une cellule ou un tissu désiré. Les immunoconjugués sont particulièrement utiles dans le traitement de tumeurs, là où, par exemple, les conjugués anticorps-doxorubicine sont efficaces contre les cellules tumorales résistant à la doxorubicine.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF EFFECTOR MOLECULES |
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