KUNITZ TYPE PROTEASE INHIBITORS
Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa and XIIa. Pharmaceutical compositions containing the KPI analogues, along wi...
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| creator | WHITE, TYLER, R GARRICK, BRETT, L LESIKAR, DAVID, D MCFADDEN, KETHLEEN DAMM, DEBORAH |
| description | Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.
L'invention se rapporte à des analogues du domaine des inhibiteurs de protéases de type Kunitz (KPI) d'une protéine précurseur amyloïde qui se lient et inhibent l'activité des sérine protéases, telles que la kallikréine, la plasmine, et des facteurs de coagulation tels que les facteurs VIIa, IXa, Xa, XIa et XIIa. Des compositions pharmaceutiques contenant les analogues de KPI, ainsi que les procédés d'utilisation de ces compositions, sont utiles pour améliorer et traiter des pathologies cliniques associées à l'activité de la sérine protéase, telles que des pertes de sang liées à des interventions chirurgicales impliquant une circulation extracorporelle. L'invention se rapporte également à des séquences nucléotidiques codant ces analogues et à des systèmes d'expression des peptides selon l'invention. |
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L'invention se rapporte à des analogues du domaine des inhibiteurs de protéases de type Kunitz (KPI) d'une protéine précurseur amyloïde qui se lient et inhibent l'activité des sérine protéases, telles que la kallikréine, la plasmine, et des facteurs de coagulation tels que les facteurs VIIa, IXa, Xa, XIa et XIIa. Des compositions pharmaceutiques contenant les analogues de KPI, ainsi que les procédés d'utilisation de ces compositions, sont utiles pour améliorer et traiter des pathologies cliniques associées à l'activité de la sérine protéase, telles que des pertes de sang liées à des interventions chirurgicales impliquant une circulation extracorporelle. L'invention se rapporte également à des séquences nucléotidiques codant ces analogues et à des systèmes d'expression des peptides selon l'invention.</description><edition>6</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961114&DB=EPODOC&CC=WO&NR=9635788A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961114&DB=EPODOC&CC=WO&NR=9635788A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WHITE, TYLER, R</creatorcontrib><creatorcontrib>GARRICK, BRETT, L</creatorcontrib><creatorcontrib>LESIKAR, DAVID, D</creatorcontrib><creatorcontrib>MCFADDEN, KETHLEEN</creatorcontrib><creatorcontrib>DAMM, DEBORAH</creatorcontrib><title>KUNITZ TYPE PROTEASE INHIBITORS</title><description>Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.
L'invention se rapporte à des analogues du domaine des inhibiteurs de protéases de type Kunitz (KPI) d'une protéine précurseur amyloïde qui se lient et inhibent l'activité des sérine protéases, telles que la kallikréine, la plasmine, et des facteurs de coagulation tels que les facteurs VIIa, IXa, Xa, XIa et XIIa. Des compositions pharmaceutiques contenant les analogues de KPI, ainsi que les procédés d'utilisation de ces compositions, sont utiles pour améliorer et traiter des pathologies cliniques associées à l'activité de la sérine protéase, telles que des pertes de sang liées à des interventions chirurgicales impliquant une circulation extracorporelle. L'invention se rapporte également à des séquences nucléotidiques codant ces analogues et à des systèmes d'expression des peptides selon l'invention.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJD3DvXzDIlSCIkMcFUICPIPcXUMdlXw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8eH-lmbGpuYWFo5GxkQoAQC7wyHT</recordid><startdate>19961114</startdate><enddate>19961114</enddate><creator>WHITE, TYLER, R</creator><creator>GARRICK, BRETT, L</creator><creator>LESIKAR, DAVID, D</creator><creator>MCFADDEN, KETHLEEN</creator><creator>DAMM, DEBORAH</creator><scope>EVB</scope></search><sort><creationdate>19961114</creationdate><title>KUNITZ TYPE PROTEASE INHIBITORS</title><author>WHITE, TYLER, R ; GARRICK, BRETT, L ; LESIKAR, DAVID, D ; MCFADDEN, KETHLEEN ; DAMM, DEBORAH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9635788A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1996</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WHITE, TYLER, R</creatorcontrib><creatorcontrib>GARRICK, BRETT, L</creatorcontrib><creatorcontrib>LESIKAR, DAVID, D</creatorcontrib><creatorcontrib>MCFADDEN, KETHLEEN</creatorcontrib><creatorcontrib>DAMM, DEBORAH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WHITE, TYLER, R</au><au>GARRICK, BRETT, L</au><au>LESIKAR, DAVID, D</au><au>MCFADDEN, KETHLEEN</au><au>DAMM, DEBORAH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>KUNITZ TYPE PROTEASE INHIBITORS</title><date>1996-11-14</date><risdate>1996</risdate><abstract>Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.
L'invention se rapporte à des analogues du domaine des inhibiteurs de protéases de type Kunitz (KPI) d'une protéine précurseur amyloïde qui se lient et inhibent l'activité des sérine protéases, telles que la kallikréine, la plasmine, et des facteurs de coagulation tels que les facteurs VIIa, IXa, Xa, XIa et XIIa. Des compositions pharmaceutiques contenant les analogues de KPI, ainsi que les procédés d'utilisation de ces compositions, sont utiles pour améliorer et traiter des pathologies cliniques associées à l'activité de la sérine protéase, telles que des pertes de sang liées à des interventions chirurgicales impliquant une circulation extracorporelle. L'invention se rapporte également à des séquences nucléotidiques codant ces analogues et à des systèmes d'expression des peptides selon l'invention.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | KUNITZ TYPE PROTEASE INHIBITORS |
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