THE PHARMACEUTICAL COMPOSITION CONTAINING THE 1,3,2-OXAZAPHOSPHORINANE AND MESNA FOR THE CANCER TREATMENT

The use of 1,3,2-oxazaphosphorinane derivatives of the general formula (I), wherein X1 and X2 are the same or different and are chlorine or bromine atom, provided that X1 and X2 are not at the same time chlorine atom, for the manufacture of the medicament for the administration together with sodium...

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Hauptverfasser: STEC, WOJCIECH, J, KUTNER, ANDRZEJ, RADZIKOWSKI, CZESDAW, GLAZMAN-KUSNIERCZYK, HALINA, MISIURA, KONRAD, KINAS, RYSZARD, SZELEJEWSKI, WIESDAW, GRYNKIEWICZ, GRZEGORZ
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creator STEC, WOJCIECH, J
KUTNER, ANDRZEJ
RADZIKOWSKI, CZESDAW
GLAZMAN-KUSNIERCZYK, HALINA
MISIURA, KONRAD
KINAS, RYSZARD
SZELEJEWSKI, WIESDAW
GRYNKIEWICZ, GRZEGORZ
description The use of 1,3,2-oxazaphosphorinane derivatives of the general formula (I), wherein X1 and X2 are the same or different and are chlorine or bromine atom, provided that X1 and X2 are not at the same time chlorine atom, for the manufacture of the medicament for the administration together with sodium 2-mercaptoethanosulfonate (mesna), pharmaceutical composition containing 1,3,2-oxazaphosphorinane derivatives of the general formula (I) as defined above and mesna, and the method of cancer treatment. Utilisation de dérivés de 1,3,2-oxazaphosphorinane répondant à la formule générale (1), dans laquelle X1 et X2, identiques ou différents, représentent un atome de chlore ou de brome, à condition que X1 et X2 ne représentent pas tous les deux un atome de chlore, dans la fabrication d'un médicament pouvant être administré en association avec du 2-mercaptoéthanosulfonate de sodium (mesna); composition pharmaceutique renfermant des dérivés de 1,3,2-oxazaphosphorinane répondant à la formule générale (1) précitée, ainsi que ledit mesna; et procédé de traitement du cancer.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title THE PHARMACEUTICAL COMPOSITION CONTAINING THE 1,3,2-OXAZAPHOSPHORINANE AND MESNA FOR THE CANCER TREATMENT
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