BCL2 DERIVED GENETIC ELEMENTS ASSOCIATED WITH SENSITIVITY TO CHEMOTHERAPEUTIC DRUGS
The invention provides genetic suppressor elements that are derived from the apoptosis-related gene BCL2. The invention provides genetic suppressor elements that are capable of inhibiting BCL2 gene expression and BCL2-mediated suppression of apoptosis in mammalian cells. The GSEs provided by the inv...
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| creator | HOLZMAYER, TATYANA, A SCHOTT, BRIGITTE RONINSON, IGOR, B TARASEWICZ, DARIUSZ, G |
| description | The invention provides genetic suppressor elements that are derived from the apoptosis-related gene BCL2. The invention provides genetic suppressor elements that are capable of inhibiting BCL2 gene expression and BCL2-mediated suppression of apoptosis in mammalian cells. The GSEs provided by the invention are also useful for sensitizing cancer cells to the cytotoxic effects of chemotherapeutic drugs. The invention provides methods for identifying and obtaining such elements, and therapeutic methods of using such elements for treatment of cancer cells and animals bearing malignant tumors.
La présente invention concerne des éléments suppresseurs génétiques dérivés du BCL2, gène lié à l'apoptose. Ces éléments suppresseurs génétiques sont capables d'inhiber l'expression du gène BCL2 et la suppression induite par BCL2, de l'apoptose dans des cellules de mammifères. Les ESG proposés par l'invention servent également à sensibiliser les cellules cancéreuses à l'action cytotoxique des agents chimiothérapeutiques. L'invention concerne aussi des moyens d'identification et d'obtention de ces éléments, ainsi que leurs applications pour le traitement thérapeutique de cellules cancéreuses et d'animaux porteurs de tumeurs malignes. |
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La présente invention concerne des éléments suppresseurs génétiques dérivés du BCL2, gène lié à l'apoptose. Ces éléments suppresseurs génétiques sont capables d'inhiber l'expression du gène BCL2 et la suppression induite par BCL2, de l'apoptose dans des cellules de mammifères. Les ESG proposés par l'invention servent également à sensibiliser les cellules cancéreuses à l'action cytotoxique des agents chimiothérapeutiques. L'invention concerne aussi des moyens d'identification et d'obtention de ces éléments, ainsi que leurs applications pour le traitement thérapeutique de cellules cancéreuses et d'animaux porteurs de tumeurs malignes.</description><edition>6</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960926&DB=EPODOC&CC=WO&NR=9629403A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960926&DB=EPODOC&CC=WO&NR=9629403A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HOLZMAYER, TATYANA, A</creatorcontrib><creatorcontrib>SCHOTT, BRIGITTE</creatorcontrib><creatorcontrib>RONINSON, IGOR, B</creatorcontrib><creatorcontrib>TARASEWICZ, DARIUSZ, G</creatorcontrib><title>BCL2 DERIVED GENETIC ELEMENTS ASSOCIATED WITH SENSITIVITY TO CHEMOTHERAPEUTIC DRUGS</title><description>The invention provides genetic suppressor elements that are derived from the apoptosis-related gene BCL2. The invention provides genetic suppressor elements that are capable of inhibiting BCL2 gene expression and BCL2-mediated suppression of apoptosis in mammalian cells. The GSEs provided by the invention are also useful for sensitizing cancer cells to the cytotoxic effects of chemotherapeutic drugs. The invention provides methods for identifying and obtaining such elements, and therapeutic methods of using such elements for treatment of cancer cells and animals bearing malignant tumors.
La présente invention concerne des éléments suppresseurs génétiques dérivés du BCL2, gène lié à l'apoptose. Ces éléments suppresseurs génétiques sont capables d'inhiber l'expression du gène BCL2 et la suppression induite par BCL2, de l'apoptose dans des cellules de mammifères. Les ESG proposés par l'invention servent également à sensibiliser les cellules cancéreuses à l'action cytotoxique des agents chimiothérapeutiques. L'invention concerne aussi des moyens d'identification et d'obtention de ces éléments, ainsi que leurs applications pour le traitement thérapeutique de cellules cancéreuses et d'animaux porteurs de tumeurs malignes.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0EKwjAQAHPxIOof9gOCtiL0mCZrs9Amkt22eCpF4km0UP-PCj7A0xxmZqm4NHUGFiN1aKFCj0IGsMYGvTBo5mBIy8f1JA4YPZNQR3IBCWAcNkEcRn3G9jva2Fa8VovbeJ_T5seVghOKcds0PYc0T-M1PdJr6ENxzIrDLtf7_I_kDbRxL-E</recordid><startdate>19960926</startdate><enddate>19960926</enddate><creator>HOLZMAYER, TATYANA, A</creator><creator>SCHOTT, BRIGITTE</creator><creator>RONINSON, IGOR, B</creator><creator>TARASEWICZ, DARIUSZ, G</creator><scope>EVB</scope></search><sort><creationdate>19960926</creationdate><title>BCL2 DERIVED GENETIC ELEMENTS ASSOCIATED WITH SENSITIVITY TO CHEMOTHERAPEUTIC DRUGS</title><author>HOLZMAYER, TATYANA, A ; SCHOTT, BRIGITTE ; RONINSON, IGOR, B ; TARASEWICZ, DARIUSZ, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9629403A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1996</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>HOLZMAYER, TATYANA, A</creatorcontrib><creatorcontrib>SCHOTT, BRIGITTE</creatorcontrib><creatorcontrib>RONINSON, IGOR, B</creatorcontrib><creatorcontrib>TARASEWICZ, DARIUSZ, G</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HOLZMAYER, TATYANA, A</au><au>SCHOTT, BRIGITTE</au><au>RONINSON, IGOR, B</au><au>TARASEWICZ, DARIUSZ, G</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BCL2 DERIVED GENETIC ELEMENTS ASSOCIATED WITH SENSITIVITY TO CHEMOTHERAPEUTIC DRUGS</title><date>1996-09-26</date><risdate>1996</risdate><abstract>The invention provides genetic suppressor elements that are derived from the apoptosis-related gene BCL2. The invention provides genetic suppressor elements that are capable of inhibiting BCL2 gene expression and BCL2-mediated suppression of apoptosis in mammalian cells. The GSEs provided by the invention are also useful for sensitizing cancer cells to the cytotoxic effects of chemotherapeutic drugs. The invention provides methods for identifying and obtaining such elements, and therapeutic methods of using such elements for treatment of cancer cells and animals bearing malignant tumors.
La présente invention concerne des éléments suppresseurs génétiques dérivés du BCL2, gène lié à l'apoptose. Ces éléments suppresseurs génétiques sont capables d'inhiber l'expression du gène BCL2 et la suppression induite par BCL2, de l'apoptose dans des cellules de mammifères. Les ESG proposés par l'invention servent également à sensibiliser les cellules cancéreuses à l'action cytotoxique des agents chimiothérapeutiques. L'invention concerne aussi des moyens d'identification et d'obtention de ces éléments, ainsi que leurs applications pour le traitement thérapeutique de cellules cancéreuses et d'animaux porteurs de tumeurs malignes.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | BCL2 DERIVED GENETIC ELEMENTS ASSOCIATED WITH SENSITIVITY TO CHEMOTHERAPEUTIC DRUGS |
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