POLYPEPTIDES USEFUL AS IMMUNOTHERAPEUTIC AGENTS AND METHODS OF POLYPEPTIDE PREPARATION
Fusion polypeptides and aggregates of polypeptides comprising papillomavirus-derived antigens, and compositions thereof and their use e.g. with adjuvants for immunogenic and vaccine purposes in eliciting e.g. HPV-specific immune responses. The polypeptides can be purified to result in aggregates whi...
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| creator | WHITTLE, NIGEL, RICHARD WILSON, MARK, JONATHAN CONNOR, STEPHEN, EDWARD THOMPSON, HENRY, STEPHEN, GRAMMER CARMICHAEL, JEREMY, PADDON |
| description | Fusion polypeptides and aggregates of polypeptides comprising papillomavirus-derived antigens, and compositions thereof and their use e.g. with adjuvants for immunogenic and vaccine purposes in eliciting e.g. HPV-specific immune responses. The polypeptides can be purified to result in aggregates which when in solution or dispersion can pass through a sterilisation filter, and in amorphous aggregates. An example of such a polypeptide is a fusion protein of human papillomavirus proteins L2 and E7.
Cette invention se rapporte à des polypeptides de fusion et à des agrégats de polypeptides, comprenant des antigènes dérivés du papillomavirus, et à des compositions de ceux-ci et à leur utilisation par exemple avec des adjuvants destinés à servir d'agents immunogènes et de vaccins dans le but de déclencher des réponses immunitaires spécifiques des papillomavirus humains. Ces polypeptides peuvent être purifier pour produire des agrégats, qui, en solution ou en dispersion, peuvent traverser un filtre de stérilisation, et pour produire des agrégats amorphes. Un exemple d'un tel polypeptide est une protéine de fusion des protéines L2 et E7 du papillomavirus humain. |
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Cette invention se rapporte à des polypeptides de fusion et à des agrégats de polypeptides, comprenant des antigènes dérivés du papillomavirus, et à des compositions de ceux-ci et à leur utilisation par exemple avec des adjuvants destinés à servir d'agents immunogènes et de vaccins dans le but de déclencher des réponses immunitaires spécifiques des papillomavirus humains. Ces polypeptides peuvent être purifier pour produire des agrégats, qui, en solution ou en dispersion, peuvent traverser un filtre de stérilisation, et pour produire des agrégats amorphes. Un exemple d'un tel polypeptide est une protéine de fusion des protéines L2 et E7 du papillomavirus humain.</description><edition>6</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960829&DB=EPODOC&CC=WO&NR=9626277A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960829&DB=EPODOC&CC=WO&NR=9626277A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WHITTLE, NIGEL, RICHARD</creatorcontrib><creatorcontrib>WILSON, MARK, JONATHAN</creatorcontrib><creatorcontrib>CONNOR, STEPHEN, EDWARD</creatorcontrib><creatorcontrib>THOMPSON, HENRY, STEPHEN, GRAMMER</creatorcontrib><creatorcontrib>CARMICHAEL, JEREMY, PADDON</creatorcontrib><title>POLYPEPTIDES USEFUL AS IMMUNOTHERAPEUTIC AGENTS AND METHODS OF POLYPEPTIDE PREPARATION</title><description>Fusion polypeptides and aggregates of polypeptides comprising papillomavirus-derived antigens, and compositions thereof and their use e.g. with adjuvants for immunogenic and vaccine purposes in eliciting e.g. HPV-specific immune responses. The polypeptides can be purified to result in aggregates which when in solution or dispersion can pass through a sterilisation filter, and in amorphous aggregates. An example of such a polypeptide is a fusion protein of human papillomavirus proteins L2 and E7.
Cette invention se rapporte à des polypeptides de fusion et à des agrégats de polypeptides, comprenant des antigènes dérivés du papillomavirus, et à des compositions de ceux-ci et à leur utilisation par exemple avec des adjuvants destinés à servir d'agents immunogènes et de vaccins dans le but de déclencher des réponses immunitaires spécifiques des papillomavirus humains. Ces polypeptides peuvent être purifier pour produire des agrégats, qui, en solution ou en dispersion, peuvent traverser un filtre de stérilisation, et pour produire des agrégats amorphes. Un exemple d'un tel polypeptide est une protéine de fusion des protéines L2 et E7 du papillomavirus humain.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNy7EKwjAQgOEuDqK-w72AgxVaHI_mYgJNLiSXilMpEifRQn1_XBwcnf7l-9fVELi_BgpiFSXIiXTuARNY57JnMRQxUBbbAZ7JSwL0ChyJYZWANfzsECIFjCiW_bZa3afHUnbfbirQJJ3Zl_k1lmWebuVZ3uOFT03d1G2Lh-Mf5AONvTEk</recordid><startdate>19960829</startdate><enddate>19960829</enddate><creator>WHITTLE, NIGEL, RICHARD</creator><creator>WILSON, MARK, JONATHAN</creator><creator>CONNOR, STEPHEN, EDWARD</creator><creator>THOMPSON, HENRY, STEPHEN, GRAMMER</creator><creator>CARMICHAEL, JEREMY, PADDON</creator><scope>EVB</scope></search><sort><creationdate>19960829</creationdate><title>POLYPEPTIDES USEFUL AS IMMUNOTHERAPEUTIC AGENTS AND METHODS OF POLYPEPTIDE PREPARATION</title><author>WHITTLE, NIGEL, RICHARD ; WILSON, MARK, JONATHAN ; CONNOR, STEPHEN, EDWARD ; THOMPSON, HENRY, STEPHEN, GRAMMER ; CARMICHAEL, JEREMY, PADDON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9626277A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1996</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WHITTLE, NIGEL, RICHARD</creatorcontrib><creatorcontrib>WILSON, MARK, JONATHAN</creatorcontrib><creatorcontrib>CONNOR, STEPHEN, EDWARD</creatorcontrib><creatorcontrib>THOMPSON, HENRY, STEPHEN, GRAMMER</creatorcontrib><creatorcontrib>CARMICHAEL, JEREMY, PADDON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WHITTLE, NIGEL, RICHARD</au><au>WILSON, MARK, JONATHAN</au><au>CONNOR, STEPHEN, EDWARD</au><au>THOMPSON, HENRY, STEPHEN, GRAMMER</au><au>CARMICHAEL, JEREMY, PADDON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>POLYPEPTIDES USEFUL AS IMMUNOTHERAPEUTIC AGENTS AND METHODS OF POLYPEPTIDE PREPARATION</title><date>1996-08-29</date><risdate>1996</risdate><abstract>Fusion polypeptides and aggregates of polypeptides comprising papillomavirus-derived antigens, and compositions thereof and their use e.g. with adjuvants for immunogenic and vaccine purposes in eliciting e.g. HPV-specific immune responses. The polypeptides can be purified to result in aggregates which when in solution or dispersion can pass through a sterilisation filter, and in amorphous aggregates. An example of such a polypeptide is a fusion protein of human papillomavirus proteins L2 and E7.
Cette invention se rapporte à des polypeptides de fusion et à des agrégats de polypeptides, comprenant des antigènes dérivés du papillomavirus, et à des compositions de ceux-ci et à leur utilisation par exemple avec des adjuvants destinés à servir d'agents immunogènes et de vaccins dans le but de déclencher des réponses immunitaires spécifiques des papillomavirus humains. Ces polypeptides peuvent être purifier pour produire des agrégats, qui, en solution ou en dispersion, peuvent traverser un filtre de stérilisation, et pour produire des agrégats amorphes. Un exemple d'un tel polypeptide est une protéine de fusion des protéines L2 et E7 du papillomavirus humain.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | POLYPEPTIDES USEFUL AS IMMUNOTHERAPEUTIC AGENTS AND METHODS OF POLYPEPTIDE PREPARATION |
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