THE PREPARATION OF IFOSFAMIDE AND ANALOGUES
A process for preparing an N-alkylphosphoramidate, e.g. ifosfamide, comprises the reaction of an N-acylphosphoramidate with a borohydride reagent in the presence of a Bronsted acid having a pKa of less than 5. L'invention concerne un procédé de préparation d'un N-alkylphosphoramidate, par...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | DYER, ULRICH, CONRAD BRENNAN, JOSEPH, JOHN |
| description | A process for preparing an N-alkylphosphoramidate, e.g. ifosfamide, comprises the reaction of an N-acylphosphoramidate with a borohydride reagent in the presence of a Bronsted acid having a pKa of less than 5.
L'invention concerne un procédé de préparation d'un N-alkylphosphoramidate, par exemple de l'ifosfamide, qui consiste en la réaction d'un N-acylphosphoramidate avec un réactif de borohydrure en présence d'un acide de Brönsted dont le pKa est inférieur à 5. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO9624600A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO9624600A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO9624600A13</originalsourceid><addsrcrecordid>eNrjZNAO8XBVCAhyDXAMcgzx9PdT8HdT8HTzD3Zz9PV0cVVw9HMBYkcff_dQ12AeBta0xJziVF4ozc2g4OYa4uyhm1qQH59aXJCYnJqXWhIf7m9pZmRiZmDgaGhMhBIAHoMkdg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>THE PREPARATION OF IFOSFAMIDE AND ANALOGUES</title><source>esp@cenet</source><creator>DYER, ULRICH, CONRAD ; BRENNAN, JOSEPH, JOHN</creator><creatorcontrib>DYER, ULRICH, CONRAD ; BRENNAN, JOSEPH, JOHN</creatorcontrib><description>A process for preparing an N-alkylphosphoramidate, e.g. ifosfamide, comprises the reaction of an N-acylphosphoramidate with a borohydride reagent in the presence of a Bronsted acid having a pKa of less than 5.
L'invention concerne un procédé de préparation d'un N-alkylphosphoramidate, par exemple de l'ifosfamide, qui consiste en la réaction d'un N-acylphosphoramidate avec un réactif de borohydrure en présence d'un acide de Brönsted dont le pKa est inférieur à 5.</description><edition>6</edition><language>eng ; fre</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960815&DB=EPODOC&CC=WO&NR=9624600A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960815&DB=EPODOC&CC=WO&NR=9624600A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DYER, ULRICH, CONRAD</creatorcontrib><creatorcontrib>BRENNAN, JOSEPH, JOHN</creatorcontrib><title>THE PREPARATION OF IFOSFAMIDE AND ANALOGUES</title><description>A process for preparing an N-alkylphosphoramidate, e.g. ifosfamide, comprises the reaction of an N-acylphosphoramidate with a borohydride reagent in the presence of a Bronsted acid having a pKa of less than 5.
L'invention concerne un procédé de préparation d'un N-alkylphosphoramidate, par exemple de l'ifosfamide, qui consiste en la réaction d'un N-acylphosphoramidate avec un réactif de borohydrure en présence d'un acide de Brönsted dont le pKa est inférieur à 5.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAO8XBVCAhyDXAMcgzx9PdT8HdT8HTzD3Zz9PV0cVVw9HMBYkcff_dQ12AeBta0xJziVF4ozc2g4OYa4uyhm1qQH59aXJCYnJqXWhIf7m9pZmRiZmDgaGhMhBIAHoMkdg</recordid><startdate>19960815</startdate><enddate>19960815</enddate><creator>DYER, ULRICH, CONRAD</creator><creator>BRENNAN, JOSEPH, JOHN</creator><scope>EVB</scope></search><sort><creationdate>19960815</creationdate><title>THE PREPARATION OF IFOSFAMIDE AND ANALOGUES</title><author>DYER, ULRICH, CONRAD ; BRENNAN, JOSEPH, JOHN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9624600A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1996</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>DYER, ULRICH, CONRAD</creatorcontrib><creatorcontrib>BRENNAN, JOSEPH, JOHN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DYER, ULRICH, CONRAD</au><au>BRENNAN, JOSEPH, JOHN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>THE PREPARATION OF IFOSFAMIDE AND ANALOGUES</title><date>1996-08-15</date><risdate>1996</risdate><abstract>A process for preparing an N-alkylphosphoramidate, e.g. ifosfamide, comprises the reaction of an N-acylphosphoramidate with a borohydride reagent in the presence of a Bronsted acid having a pKa of less than 5.
L'invention concerne un procédé de préparation d'un N-alkylphosphoramidate, par exemple de l'ifosfamide, qui consiste en la réaction d'un N-acylphosphoramidate avec un réactif de borohydrure en présence d'un acide de Brönsted dont le pKa est inférieur à 5.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO9624600A1 |
| source | esp@cenet |
| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY METALLURGY ORGANIC CHEMISTRY |
| title | THE PREPARATION OF IFOSFAMIDE AND ANALOGUES |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T06%3A49%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=DYER,%20ULRICH,%20CONRAD&rft.date=1996-08-15&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO9624600A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |