BORONIC ACID AND ESTER INHIBITORS OF THROMBIN
Novel boronic acid and ester and carboxyl-modified amino acid compounds of formula (I): R -Z-CHR -A, which are inhibitors of trypsin-like enzymes, are disclosed, where R , Z, R and A are defined within. La présente invention porte sur de nouveaux composés d'acide boré, d'ester et d'ac...
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| creator | WITYAK, JOHN WEBER, PATRICIA, CAROL DUNCIA, JOHN, JONAS, VYTAUTAS AMPARO, EUGENE, CRUZ PACOFSKY, GREGORY, JAMES SANTELLA, JOSEPH, BASIL, III MILLER, WILLIAM, HENRY |
| description | Novel boronic acid and ester and carboxyl-modified amino acid compounds of formula (I): R -Z-CHR -A, which are inhibitors of trypsin-like enzymes, are disclosed, where R , Z, R and A are defined within.
La présente invention porte sur de nouveaux composés d'acide boré, d'ester et d'acide aminique modifié par carboxyle, inhibiteurs d'enzymes de type trypsine, faisant partie de la formule (I): R -Z-CHR -A, formule dans laquelle R , Z, R et A sont définis dans la présente invention. |
| format | Patent |
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La présente invention porte sur de nouveaux composés d'acide boré, d'ester et d'acide aminique modifié par carboxyle, inhibiteurs d'enzymes de type trypsine, faisant partie de la formule (I): R -Z-CHR -A, formule dans laquelle R , Z, R et A sont définis dans la présente invention.</description><edition>6</edition><language>eng ; fre</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960711&DB=EPODOC&CC=WO&NR=9620689A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960711&DB=EPODOC&CC=WO&NR=9620689A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WITYAK, JOHN</creatorcontrib><creatorcontrib>WEBER, PATRICIA, CAROL</creatorcontrib><creatorcontrib>DUNCIA, JOHN, JONAS, VYTAUTAS</creatorcontrib><creatorcontrib>AMPARO, EUGENE, CRUZ</creatorcontrib><creatorcontrib>PACOFSKY, GREGORY, JAMES</creatorcontrib><creatorcontrib>SANTELLA, JOSEPH, BASIL, III</creatorcontrib><creatorcontrib>MILLER, WILLIAM, HENRY</creatorcontrib><title>BORONIC ACID AND ESTER INHIBITORS OF THROMBIN</title><description>Novel boronic acid and ester and carboxyl-modified amino acid compounds of formula (I): R -Z-CHR -A, which are inhibitors of trypsin-like enzymes, are disclosed, where R , Z, R and A are defined within.
La présente invention porte sur de nouveaux composés d'acide boré, d'ester et d'acide aminique modifié par carboxyle, inhibiteurs d'enzymes de type trypsine, faisant partie de la formule (I): R -Z-CHR -A, formule dans laquelle R , Z, R et A sont définis dans la présente invention.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB18g_y9_N0VnB09nRRcPRzUXANDnENUvD08_B08gzxDwpW8HdTCPEI8vd18vTjYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXx4f6WZkYGZhaWjkbGRCgBAGDwJRY</recordid><startdate>19960711</startdate><enddate>19960711</enddate><creator>WITYAK, JOHN</creator><creator>WEBER, PATRICIA, CAROL</creator><creator>DUNCIA, JOHN, JONAS, VYTAUTAS</creator><creator>AMPARO, EUGENE, CRUZ</creator><creator>PACOFSKY, GREGORY, JAMES</creator><creator>SANTELLA, JOSEPH, BASIL, III</creator><creator>MILLER, WILLIAM, HENRY</creator><scope>EVB</scope></search><sort><creationdate>19960711</creationdate><title>BORONIC ACID AND ESTER INHIBITORS OF THROMBIN</title><author>WITYAK, JOHN ; WEBER, PATRICIA, CAROL ; DUNCIA, JOHN, JONAS, VYTAUTAS ; AMPARO, EUGENE, CRUZ ; PACOFSKY, GREGORY, JAMES ; SANTELLA, JOSEPH, BASIL, III ; MILLER, WILLIAM, HENRY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9620689A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1996</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>WITYAK, JOHN</creatorcontrib><creatorcontrib>WEBER, PATRICIA, CAROL</creatorcontrib><creatorcontrib>DUNCIA, JOHN, JONAS, VYTAUTAS</creatorcontrib><creatorcontrib>AMPARO, EUGENE, CRUZ</creatorcontrib><creatorcontrib>PACOFSKY, GREGORY, JAMES</creatorcontrib><creatorcontrib>SANTELLA, JOSEPH, BASIL, III</creatorcontrib><creatorcontrib>MILLER, WILLIAM, HENRY</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WITYAK, JOHN</au><au>WEBER, PATRICIA, CAROL</au><au>DUNCIA, JOHN, JONAS, VYTAUTAS</au><au>AMPARO, EUGENE, CRUZ</au><au>PACOFSKY, GREGORY, JAMES</au><au>SANTELLA, JOSEPH, BASIL, III</au><au>MILLER, WILLIAM, HENRY</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BORONIC ACID AND ESTER INHIBITORS OF THROMBIN</title><date>1996-07-11</date><risdate>1996</risdate><abstract>Novel boronic acid and ester and carboxyl-modified amino acid compounds of formula (I): R -Z-CHR -A, which are inhibitors of trypsin-like enzymes, are disclosed, where R , Z, R and A are defined within.
La présente invention porte sur de nouveaux composés d'acide boré, d'ester et d'acide aminique modifié par carboxyle, inhibiteurs d'enzymes de type trypsine, faisant partie de la formule (I): R -Z-CHR -A, formule dans laquelle R , Z, R et A sont définis dans la présente invention.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | BORONIC ACID AND ESTER INHIBITORS OF THROMBIN |
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