A NUCLEOTIDE SEQUENCE ENCODING A CHROMOSOMAL PROTEIN, ASSOCIATED CHROMOSOMAL PROTEINS AND THEIR USES
The invention concerns a novel isolated nucleic acid molecule encoding a mitosis-associated nuclear antigen, wherein said antigen is about 47 kD, is capable of being phosphorylated during mitosis and is capable of being a substrate for cdc2 kinase, or a derivative, variant, homologue, analogue, or f...
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| creator | TOH, BAN-HOCK YEO, JING, PING ALDERUCCIO, FRANK |
| description | The invention concerns a novel isolated nucleic acid molecule encoding a mitosis-associated nuclear antigen, wherein said antigen is about 47 kD, is capable of being phosphorylated during mitosis and is capable of being a substrate for cdc2 kinase, or a derivative, variant, homologue, analogue, or fragment of said nucleic acid molecule which is functionally related to said nucleic acid molecule. The invention also relates to an isolated protein comprising a mitosis-associated nuclear antigen of about 47 kD which is capable of being phosphorylated during mitosis and is capable of being a substrate for cdc2 kinase, other associated proteins and uses for the nucleic acid molecules and the proteins including methods of diagnosis and treatment of diseases and pharmaceutical preparations.
Nouvelle molécule d'acide nucléique isolée codant un antigène nucléaire associé à la mitose, ledit antigène d'environ 47 kD pouvant être phosphorylé pendant la mitose et constituer un substrat pour la cdc2 kinase, ou dérivé, variante, homologue, analogue ou fragment de ladite molécule d'acide nucléique qui est fonctionnellement en rapport avec ladite molécule d'acide nucléique. La présente invention concerne également une protéine isolée comportant un antigène nucléaire associé à la mitose, d'environ 47 kD, pouvant être phosphorylé pendant la mitose et constituer un substrat pour la cdc2 kinase, d'autres protéines associées et les utilisations desdites molécules d'acide nucléique et protéines, ainsi que des méthodes de diagnostic et de traitement de maladies et des préparations pharmaceutiques. |
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Nouvelle molécule d'acide nucléique isolée codant un antigène nucléaire associé à la mitose, ledit antigène d'environ 47 kD pouvant être phosphorylé pendant la mitose et constituer un substrat pour la cdc2 kinase, ou dérivé, variante, homologue, analogue ou fragment de ladite molécule d'acide nucléique qui est fonctionnellement en rapport avec ladite molécule d'acide nucléique. La présente invention concerne également une protéine isolée comportant un antigène nucléaire associé à la mitose, d'environ 47 kD, pouvant être phosphorylé pendant la mitose et constituer un substrat pour la cdc2 kinase, d'autres protéines associées et les utilisations desdites molécules d'acide nucléique et protéines, ainsi que des méthodes de diagnostic et de traitement de maladies et des préparations pharmaceutiques.</description><edition>5</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941013&DB=EPODOC&CC=WO&NR=9423029A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941013&DB=EPODOC&CC=WO&NR=9423029A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TOH, BAN-HOCK</creatorcontrib><creatorcontrib>YEO, JING, PING</creatorcontrib><creatorcontrib>ALDERUCCIO, FRANK</creatorcontrib><title>A NUCLEOTIDE SEQUENCE ENCODING A CHROMOSOMAL PROTEIN, ASSOCIATED CHROMOSOMAL PROTEINS AND THEIR USES</title><description>The invention concerns a novel isolated nucleic acid molecule encoding a mitosis-associated nuclear antigen, wherein said antigen is about 47 kD, is capable of being phosphorylated during mitosis and is capable of being a substrate for cdc2 kinase, or a derivative, variant, homologue, analogue, or fragment of said nucleic acid molecule which is functionally related to said nucleic acid molecule. The invention also relates to an isolated protein comprising a mitosis-associated nuclear antigen of about 47 kD which is capable of being phosphorylated during mitosis and is capable of being a substrate for cdc2 kinase, other associated proteins and uses for the nucleic acid molecules and the proteins including methods of diagnosis and treatment of diseases and pharmaceutical preparations.
Nouvelle molécule d'acide nucléique isolée codant un antigène nucléaire associé à la mitose, ledit antigène d'environ 47 kD pouvant être phosphorylé pendant la mitose et constituer un substrat pour la cdc2 kinase, ou dérivé, variante, homologue, analogue ou fragment de ladite molécule d'acide nucléique qui est fonctionnellement en rapport avec ladite molécule d'acide nucléique. La présente invention concerne également une protéine isolée comportant un antigène nucléaire associé à la mitose, d'environ 47 kD, pouvant être phosphorylé pendant la mitose et constituer un substrat pour la cdc2 kinase, d'autres protéines associées et les utilisations desdites molécules d'acide nucléique et protéines, ainsi que des méthodes de diagnostic et de traitement de maladies et des préparations pharmaceutiques.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1994</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirEKwjAQQLM4iPoP9wEWtHXpeCSnCbQ5zSV0LMXGSbRQ_x8dHB1c3hveW6oRwSfdEEdnCIQuibwm-ICN8ydA0DZwy8ItNnAOHMn5LaAIa4eRzK8ugN5AtOQCJCFZq8VtuM958_VKwZGitkWenn2ep-GaH_nVd1wfympX1riv_lje7kA0VQ</recordid><startdate>19941013</startdate><enddate>19941013</enddate><creator>TOH, BAN-HOCK</creator><creator>YEO, JING, PING</creator><creator>ALDERUCCIO, FRANK</creator><scope>EVB</scope></search><sort><creationdate>19941013</creationdate><title>A NUCLEOTIDE SEQUENCE ENCODING A CHROMOSOMAL PROTEIN, ASSOCIATED CHROMOSOMAL PROTEINS AND THEIR USES</title><author>TOH, BAN-HOCK ; YEO, JING, PING ; ALDERUCCIO, FRANK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9423029A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1994</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>TOH, BAN-HOCK</creatorcontrib><creatorcontrib>YEO, JING, PING</creatorcontrib><creatorcontrib>ALDERUCCIO, FRANK</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TOH, BAN-HOCK</au><au>YEO, JING, PING</au><au>ALDERUCCIO, FRANK</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A NUCLEOTIDE SEQUENCE ENCODING A CHROMOSOMAL PROTEIN, ASSOCIATED CHROMOSOMAL PROTEINS AND THEIR USES</title><date>1994-10-13</date><risdate>1994</risdate><abstract>The invention concerns a novel isolated nucleic acid molecule encoding a mitosis-associated nuclear antigen, wherein said antigen is about 47 kD, is capable of being phosphorylated during mitosis and is capable of being a substrate for cdc2 kinase, or a derivative, variant, homologue, analogue, or fragment of said nucleic acid molecule which is functionally related to said nucleic acid molecule. The invention also relates to an isolated protein comprising a mitosis-associated nuclear antigen of about 47 kD which is capable of being phosphorylated during mitosis and is capable of being a substrate for cdc2 kinase, other associated proteins and uses for the nucleic acid molecules and the proteins including methods of diagnosis and treatment of diseases and pharmaceutical preparations.
Nouvelle molécule d'acide nucléique isolée codant un antigène nucléaire associé à la mitose, ledit antigène d'environ 47 kD pouvant être phosphorylé pendant la mitose et constituer un substrat pour la cdc2 kinase, ou dérivé, variante, homologue, analogue ou fragment de ladite molécule d'acide nucléique qui est fonctionnellement en rapport avec ladite molécule d'acide nucléique. La présente invention concerne également une protéine isolée comportant un antigène nucléaire associé à la mitose, d'environ 47 kD, pouvant être phosphorylé pendant la mitose et constituer un substrat pour la cdc2 kinase, d'autres protéines associées et les utilisations desdites molécules d'acide nucléique et protéines, ainsi que des méthodes de diagnostic et de traitement de maladies et des préparations pharmaceutiques.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | A NUCLEOTIDE SEQUENCE ENCODING A CHROMOSOMAL PROTEIN, ASSOCIATED CHROMOSOMAL PROTEINS AND THEIR USES |
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