NOVEL COMBINATION OF BENZOQUINAZOLINE ANTIFOLATES AND PROTECTING AGENTS

The use of a protecting agent, for example a folate derivative such as folic acid or leucovorin, in combination with a non-competitive folic acid analogue, for example benzoquinazoline derivatives, for use in reducing the side effects associated with the administration of such non-competitive folic...

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Bibliographische Detailangaben
Hauptverfasser:	SMITH, GARY, KEITH, KOCH, ARTHUR, DUCH, DAVID, STANLEY, FERONE, ROBERT
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The use of a protecting agent, for example a folate derivative such as folic acid or leucovorin, in combination with a non-competitive folic acid analogue, for example benzoquinazoline derivatives, for use in reducing the side effects associated with the administration of such non-competitive folic acid analogues, and pharmaceutical formulations comprising such combinations are disclosed. Utilisation d'un agent protecteur, par exemple un dérivé de folate tel que l'acide folique ou la leucovorine, en combinaison avec un analogue d'acide folique non compétitif tels que des dérivés de benzoquinazoline, pour réduire les effets secondaires associés à l'administration de tels analogues d'acide folique non compétitifs. Des formulations pharmaceutiques comprenant de telles combinaisons sont également décrites.