MONOCLONAL ANTIBODIES FOR RECOGNIZING A PEPTIDE LINKED TO A MAJOR HISTOCOMPATIBILITY ANTIGEN
Restricted monoclonal antibodies characterized by their ability to recognize specifically a complex consisting of a peptide which is characteristic of a pathogenic agent antigen or a cell derangement, and a Major Histocompatibility Complex (MHC) molecule having the ability to recognize and fix this...
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| creator | HUYNH THIEN DUC, GUY KOURILSKY, PHILIPPE RUCAY, PIERRE |
| description | Restricted monoclonal antibodies characterized by their ability to recognize specifically a complex consisting of a peptide which is characteristic of a pathogenic agent antigen or a cell derangement, and a Major Histocompatibility Complex (MHC) molecule having the ability to recognize and fix this peptide, said antibodies being restricted monoclonal antibodies in that they are unable to recognize said peptide combined with a non peptide specific haplotype MHC molecule. These antibodies can be used to diagnose conditions caused by infectious agents or cell derangements to be found for example in tumors or autoimmune diseases.
L'invention concerne des anticorps monoclonaux restreints caractérisés par leur capacité à reconnaître spécifiquement un complexe formé par un peptide caractéristique d'un antigène d'un agent pathogène ou un peptide caractéristique d'une dérégulation cellulaire et par une molécule du Complexe Majeur d'Histocompatibilité (CMH) ayant la capacité de reconnaître et de fixer ce peptide, lesdits anticorps étant des anticorps monoclonaux restreints, dès lors qu'ils ne reconnaissent pas ledit peptide en association avec une molécule de CMH d'haplotype non spécifique du peptide. Elle vise aussi l'application de ces anticorps au diagnostic de pathologies dues à des agents infectieux ou à des dérèglements cellulaires impliqués par exemple dans des tumeurs ou des maladies autoimmunes. |
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L'invention concerne des anticorps monoclonaux restreints caractérisés par leur capacité à reconnaître spécifiquement un complexe formé par un peptide caractéristique d'un antigène d'un agent pathogène ou un peptide caractéristique d'une dérégulation cellulaire et par une molécule du Complexe Majeur d'Histocompatibilité (CMH) ayant la capacité de reconnaître et de fixer ce peptide, lesdits anticorps étant des anticorps monoclonaux restreints, dès lors qu'ils ne reconnaissent pas ledit peptide en association avec une molécule de CMH d'haplotype non spécifique du peptide. Elle vise aussi l'application de ces anticorps au diagnostic de pathologies dues à des agents infectieux ou à des dérèglements cellulaires impliqués par exemple dans des tumeurs ou des maladies autoimmunes.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>1991</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910822&DB=EPODOC&CC=WO&NR=9112332A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910822&DB=EPODOC&CC=WO&NR=9112332A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HUYNH THIEN DUC, GUY</creatorcontrib><creatorcontrib>KOURILSKY, PHILIPPE</creatorcontrib><creatorcontrib>RUCAY, PIERRE</creatorcontrib><title>MONOCLONAL ANTIBODIES FOR RECOGNIZING A PEPTIDE LINKED TO A MAJOR HISTOCOMPATIBILITY ANTIGEN</title><description>Restricted monoclonal antibodies characterized by their ability to recognize specifically a complex consisting of a peptide which is characteristic of a pathogenic agent antigen or a cell derangement, and a Major Histocompatibility Complex (MHC) molecule having the ability to recognize and fix this peptide, said antibodies being restricted monoclonal antibodies in that they are unable to recognize said peptide combined with a non peptide specific haplotype MHC molecule. These antibodies can be used to diagnose conditions caused by infectious agents or cell derangements to be found for example in tumors or autoimmune diseases.
L'invention concerne des anticorps monoclonaux restreints caractérisés par leur capacité à reconnaître spécifiquement un complexe formé par un peptide caractéristique d'un antigène d'un agent pathogène ou un peptide caractéristique d'une dérégulation cellulaire et par une molécule du Complexe Majeur d'Histocompatibilité (CMH) ayant la capacité de reconnaître et de fixer ce peptide, lesdits anticorps étant des anticorps monoclonaux restreints, dès lors qu'ils ne reconnaissent pas ledit peptide en association avec une molécule de CMH d'haplotype non spécifique du peptide. Elle vise aussi l'application de ces anticorps au diagnostic de pathologies dues à des agents infectieux ou à des dérèglements cellulaires impliqués par exemple dans des tumeurs ou des maladies autoimmunes.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1991</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEEKwjAQRbtxIeod5gIu2qxcxmTajiYzoQ2IIpQicSVaqPfHIB7A1YPP-29ZXL2wGCesHWiOtBdL2EMtHXRopGG6EDegIWCIZBEc8REtRMmb14fstdRHMeKDzndyFM_fUoO8Lhb38TGnzY-rAmqMpt2m6TWkeRpv6Znew0l2ZVkpVelS_aF8AF97Mhg</recordid><startdate>19910822</startdate><enddate>19910822</enddate><creator>HUYNH THIEN DUC, GUY</creator><creator>KOURILSKY, PHILIPPE</creator><creator>RUCAY, PIERRE</creator><scope>EVB</scope></search><sort><creationdate>19910822</creationdate><title>MONOCLONAL ANTIBODIES FOR RECOGNIZING A PEPTIDE LINKED TO A MAJOR HISTOCOMPATIBILITY ANTIGEN</title><author>HUYNH THIEN DUC, GUY ; KOURILSKY, PHILIPPE ; RUCAY, PIERRE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9112332A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1991</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>HUYNH THIEN DUC, GUY</creatorcontrib><creatorcontrib>KOURILSKY, PHILIPPE</creatorcontrib><creatorcontrib>RUCAY, PIERRE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HUYNH THIEN DUC, GUY</au><au>KOURILSKY, PHILIPPE</au><au>RUCAY, PIERRE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MONOCLONAL ANTIBODIES FOR RECOGNIZING A PEPTIDE LINKED TO A MAJOR HISTOCOMPATIBILITY ANTIGEN</title><date>1991-08-22</date><risdate>1991</risdate><abstract>Restricted monoclonal antibodies characterized by their ability to recognize specifically a complex consisting of a peptide which is characteristic of a pathogenic agent antigen or a cell derangement, and a Major Histocompatibility Complex (MHC) molecule having the ability to recognize and fix this peptide, said antibodies being restricted monoclonal antibodies in that they are unable to recognize said peptide combined with a non peptide specific haplotype MHC molecule. These antibodies can be used to diagnose conditions caused by infectious agents or cell derangements to be found for example in tumors or autoimmune diseases.
L'invention concerne des anticorps monoclonaux restreints caractérisés par leur capacité à reconnaître spécifiquement un complexe formé par un peptide caractéristique d'un antigène d'un agent pathogène ou un peptide caractéristique d'une dérégulation cellulaire et par une molécule du Complexe Majeur d'Histocompatibilité (CMH) ayant la capacité de reconnaître et de fixer ce peptide, lesdits anticorps étant des anticorps monoclonaux restreints, dès lors qu'ils ne reconnaissent pas ledit peptide en association avec une molécule de CMH d'haplotype non spécifique du peptide. Elle vise aussi l'application de ces anticorps au diagnostic de pathologies dues à des agents infectieux ou à des dérèglements cellulaires impliqués par exemple dans des tumeurs ou des maladies autoimmunes.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | MONOCLONAL ANTIBODIES FOR RECOGNIZING A PEPTIDE LINKED TO A MAJOR HISTOCOMPATIBILITY ANTIGEN |
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