COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY
Cyclodextrin derivatives and inclusion complexes having increased solubility and stability are provided. Cyclodextrin derivatives include amino and other modified cyclodextrins, and linked cyclodextrins. Inclusion complexes comprising the foregoing cyclodextrins, and processes for making the cyclode...
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| creator | STILE, MARTYN, ALLEN VAN EYK, STEPHEN, JOHN MAY, BRUCE, LINDLY LINCOLN, STEPHEN, FREDERICK EASTON, CHRISTOPHER, JOHN WILLIAMS, MICHAEL, LLOYD SINGH, PARAMJIT COATES, JOHN, HEWLETT |
| description | Cyclodextrin derivatives and inclusion complexes having increased solubility and stability are provided. Cyclodextrin derivatives include amino and other modified cyclodextrins, and linked cyclodextrins. Inclusion complexes comprising the foregoing cyclodextrins, and processes for making the cyclodextrin derivatives are disclosed. Also disclosed are cyclodextrin derivatives comprising otherwise substituted or unsubstituted cyclodextrins covalently bonded to agents such as pharmaceuticals. The covalent bond, when broken, yields the agent in active form. Pharmaceutical compositions and methods of treating an animal host are also described, as well as chromatographic compositions and a method for separating racemic mixtures.
Dérivés de cyclodextrine et complexes d'inclusion se caractérisant par une solubilité et une stabilité accrues. Les dérivés de cyclodextrine décrits contiennent des cyclodextrines amino et d'autres cyclodextrines modifiées, ainsi que des cyclodextrines avec liaisons entre elles. Des complexes d'inclusion comprenant les cyclodextrines mentionnées et des procédés de production des dérivés de cyclodextrine sont décrits. Des dérivés de cyclodextrine comprenant des cyclodextrines autrement substituées ou non substituées, liées par liaisons covalentes à des agents tels que des produits pharmaceutiques, sont également décrits. Une fois rompue, la liaison covalente donne à l'agent sa forme active. Des compositions pharmaceutiques et des procédés de traitement pour hôtes animaux, ainsi que des compositions chromatographiques et un procédé servant à la séparation de mélanges racémiques sont également décrits. |
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Dérivés de cyclodextrine et complexes d'inclusion se caractérisant par une solubilité et une stabilité accrues. Les dérivés de cyclodextrine décrits contiennent des cyclodextrines amino et d'autres cyclodextrines modifiées, ainsi que des cyclodextrines avec liaisons entre elles. Des complexes d'inclusion comprenant les cyclodextrines mentionnées et des procédés de production des dérivés de cyclodextrine sont décrits. Des dérivés de cyclodextrine comprenant des cyclodextrines autrement substituées ou non substituées, liées par liaisons covalentes à des agents tels que des produits pharmaceutiques, sont également décrits. Une fois rompue, la liaison covalente donne à l'agent sa forme active. Des compositions pharmaceutiques et des procédés de traitement pour hôtes animaux, ainsi que des compositions chromatographiques et un procédé servant à la séparation de mélanges racémiques sont également décrits.</description><edition>4</edition><language>eng</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; CHEMISTRY ; COMPOSITIONS BASED THEREON ; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS ; DERIVATIVES THEREOF ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PEST REPELLANTS OR ATTRACTANTS ; PHYSICS ; PLANT GROWTH REGULATORS ; POLYSACCHARIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF ; TESTING ; THEIR PREPARATION OR CHEMICAL WORKING-UP ; TRAPPING</subject><creationdate>1990</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900308&DB=EPODOC&CC=WO&NR=9002141A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900308&DB=EPODOC&CC=WO&NR=9002141A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>STILE, MARTYN, ALLEN</creatorcontrib><creatorcontrib>VAN EYK, STEPHEN, JOHN</creatorcontrib><creatorcontrib>MAY, BRUCE, LINDLY</creatorcontrib><creatorcontrib>LINCOLN, STEPHEN, FREDERICK</creatorcontrib><creatorcontrib>EASTON, CHRISTOPHER, JOHN</creatorcontrib><creatorcontrib>WILLIAMS, MICHAEL, LLOYD</creatorcontrib><creatorcontrib>SINGH, PARAMJIT</creatorcontrib><creatorcontrib>COATES, JOHN, HEWLETT</creatorcontrib><title>COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY</title><description>Cyclodextrin derivatives and inclusion complexes having increased solubility and stability are provided. Cyclodextrin derivatives include amino and other modified cyclodextrins, and linked cyclodextrins. Inclusion complexes comprising the foregoing cyclodextrins, and processes for making the cyclodextrin derivatives are disclosed. Also disclosed are cyclodextrin derivatives comprising otherwise substituted or unsubstituted cyclodextrins covalently bonded to agents such as pharmaceuticals. The covalent bond, when broken, yields the agent in active form. Pharmaceutical compositions and methods of treating an animal host are also described, as well as chromatographic compositions and a method for separating racemic mixtures.
Dérivés de cyclodextrine et complexes d'inclusion se caractérisant par une solubilité et une stabilité accrues. Les dérivés de cyclodextrine décrits contiennent des cyclodextrines amino et d'autres cyclodextrines modifiées, ainsi que des cyclodextrines avec liaisons entre elles. Des complexes d'inclusion comprenant les cyclodextrines mentionnées et des procédés de production des dérivés de cyclodextrine sont décrits. Des dérivés de cyclodextrine comprenant des cyclodextrines autrement substituées ou non substituées, liées par liaisons covalentes à des agents tels que des produits pharmaceutiques, sont également décrits. Une fois rompue, la liaison covalente donne à l'agent sa forme active. Des compositions pharmaceutiques et des procédés de traitement pour hôtes animaux, ainsi que des compositions chromatographiques et un procédé servant à la séparation de mélanges racémiques sont également décrits.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>COMPOSITIONS OF MACROMOLECULAR COMPOUNDS</subject><subject>DERIVATIVES THEREOF</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PHYSICS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>POLYSACCHARIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>TESTING</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><subject>TRAPPING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1990</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB19vcN8A_2DPH09wtWcPRzUfB1DfHwdwlWcPMPUnAJCnVXcHH18QxzDYoEyzp7BPn7Oob4uwc5BnhE8jCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSS-HB_SwMDI0MTQ0dDYyKUAAD5dym2</recordid><startdate>19900308</startdate><enddate>19900308</enddate><creator>STILE, MARTYN, ALLEN</creator><creator>VAN EYK, STEPHEN, JOHN</creator><creator>MAY, BRUCE, LINDLY</creator><creator>LINCOLN, STEPHEN, FREDERICK</creator><creator>EASTON, CHRISTOPHER, JOHN</creator><creator>WILLIAMS, MICHAEL, LLOYD</creator><creator>SINGH, PARAMJIT</creator><creator>COATES, JOHN, HEWLETT</creator><scope>EVB</scope></search><sort><creationdate>19900308</creationdate><title>COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY</title><author>STILE, MARTYN, ALLEN ; VAN EYK, STEPHEN, JOHN ; MAY, BRUCE, LINDLY ; LINCOLN, STEPHEN, FREDERICK ; EASTON, CHRISTOPHER, JOHN ; WILLIAMS, MICHAEL, LLOYD ; SINGH, PARAMJIT ; COATES, JOHN, HEWLETT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9002141A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1990</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>COMPOSITIONS OF MACROMOLECULAR COMPOUNDS</topic><topic>DERIVATIVES THEREOF</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>PEST REPELLANTS OR ATTRACTANTS</topic><topic>PHYSICS</topic><topic>PLANT GROWTH REGULATORS</topic><topic>POLYSACCHARIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</topic><topic>TESTING</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><topic>TRAPPING</topic><toplevel>online_resources</toplevel><creatorcontrib>STILE, MARTYN, ALLEN</creatorcontrib><creatorcontrib>VAN EYK, STEPHEN, JOHN</creatorcontrib><creatorcontrib>MAY, BRUCE, LINDLY</creatorcontrib><creatorcontrib>LINCOLN, STEPHEN, FREDERICK</creatorcontrib><creatorcontrib>EASTON, CHRISTOPHER, JOHN</creatorcontrib><creatorcontrib>WILLIAMS, MICHAEL, LLOYD</creatorcontrib><creatorcontrib>SINGH, PARAMJIT</creatorcontrib><creatorcontrib>COATES, JOHN, HEWLETT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>STILE, MARTYN, ALLEN</au><au>VAN EYK, STEPHEN, JOHN</au><au>MAY, BRUCE, LINDLY</au><au>LINCOLN, STEPHEN, FREDERICK</au><au>EASTON, CHRISTOPHER, JOHN</au><au>WILLIAMS, MICHAEL, LLOYD</au><au>SINGH, PARAMJIT</au><au>COATES, JOHN, HEWLETT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY</title><date>1990-03-08</date><risdate>1990</risdate><abstract>Cyclodextrin derivatives and inclusion complexes having increased solubility and stability are provided. Cyclodextrin derivatives include amino and other modified cyclodextrins, and linked cyclodextrins. Inclusion complexes comprising the foregoing cyclodextrins, and processes for making the cyclodextrin derivatives are disclosed. Also disclosed are cyclodextrin derivatives comprising otherwise substituted or unsubstituted cyclodextrins covalently bonded to agents such as pharmaceuticals. The covalent bond, when broken, yields the agent in active form. Pharmaceutical compositions and methods of treating an animal host are also described, as well as chromatographic compositions and a method for separating racemic mixtures.
Dérivés de cyclodextrine et complexes d'inclusion se caractérisant par une solubilité et une stabilité accrues. Les dérivés de cyclodextrine décrits contiennent des cyclodextrines amino et d'autres cyclodextrines modifiées, ainsi que des cyclodextrines avec liaisons entre elles. Des complexes d'inclusion comprenant les cyclodextrines mentionnées et des procédés de production des dérivés de cyclodextrine sont décrits. Des dérivés de cyclodextrine comprenant des cyclodextrines autrement substituées ou non substituées, liées par liaisons covalentes à des agents tels que des produits pharmaceutiques, sont également décrits. Une fois rompue, la liaison covalente donne à l'agent sa forme active. Des compositions pharmaceutiques et des procédés de traitement pour hôtes animaux, ainsi que des compositions chromatographiques et un procédé servant à la séparation de mélanges racémiques sont également décrits.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS DERIVATIVES THEREOF FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PEST REPELLANTS OR ATTRACTANTS PHYSICS PLANT GROWTH REGULATORS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TESTING THEIR PREPARATION OR CHEMICAL WORKING-UP TRAPPING |
| title | COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY |
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