COLLAGEN-SPECIFIC ENZYME WITH PLATELET AGGREGATION INHIBITION PROPERTIES
The collagenase is like tissue collagenases in that it cleaves collagen at a single site. The collagenase which has a molecular weight of about 50k daltons, specifically inhibits collagen-induced platelet aggregation, with substantially no effect on platelet count or size, and may be used alone or t...
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| creator | LEVY, HAIM SAWYER, ROY, THOMAS RIGBI, MEIR IRAKI, FUAD |
| description | The collagenase is like tissue collagenases in that it cleaves collagen at a single site. The collagenase which has a molecular weight of about 50k daltons, specifically inhibits collagen-induced platelet aggregation, with substantially no effect on platelet count or size, and may be used alone or together with another platelet aggregation inhibitor. The latter may also be a leech-derived biochemical, such as an apyrase, or an inhibitor of the release of platelet aggregation factor by leucocytes.
La collagénase est comme les collagénases tissulaires dans la mesure où elle effectue le clivage du collagène en un seul site. La collagénase, qui possède un poids moléculaire d'environ 50k daltons, inhibe de manière spécifique l'agrégation des plaquettes induites par le collagène, avec pratiquement aucun effet sur le comptage ou les dimensions des plaquettes, et elle peut être utilisée seule ou avec un autre inhibiteur de l'agrégation des plaquettes. Ce dernier peut être aussi un agent biochimique dérivé des sangsues, tel qu'une apyrase, ou un inhibiteur de la libération du facteur d'agrégation des plaquettes par des leucocytes. |
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La collagénase est comme les collagénases tissulaires dans la mesure où elle effectue le clivage du collagène en un seul site. La collagénase, qui possède un poids moléculaire d'environ 50k daltons, inhibe de manière spécifique l'agrégation des plaquettes induites par le collagène, avec pratiquement aucun effet sur le comptage ou les dimensions des plaquettes, et elle peut être utilisée seule ou avec un autre inhibiteur de l'agrégation des plaquettes. Ce dernier peut être aussi un agent biochimique dérivé des sangsues, tel qu'une apyrase, ou un inhibiteur de la libération du facteur d'agrégation des plaquettes par des leucocytes.</description><edition>4</edition><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1987</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870212&DB=EPODOC&CC=WO&NR=8700860A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870212&DB=EPODOC&CC=WO&NR=8700860A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEVY, HAIM</creatorcontrib><creatorcontrib>SAWYER, ROY, THOMAS</creatorcontrib><creatorcontrib>RIGBI, MEIR</creatorcontrib><creatorcontrib>IRAKI, FUAD</creatorcontrib><title>COLLAGEN-SPECIFIC ENZYME WITH PLATELET AGGREGATION INHIBITION PROPERTIES</title><description>The collagenase is like tissue collagenases in that it cleaves collagen at a single site. The collagenase which has a molecular weight of about 50k daltons, specifically inhibits collagen-induced platelet aggregation, with substantially no effect on platelet count or size, and may be used alone or together with another platelet aggregation inhibitor. The latter may also be a leech-derived biochemical, such as an apyrase, or an inhibitor of the release of platelet aggregation factor by leucocytes.
La collagénase est comme les collagénases tissulaires dans la mesure où elle effectue le clivage du collagène en un seul site. La collagénase, qui possède un poids moléculaire d'environ 50k daltons, inhibe de manière spécifique l'agrégation des plaquettes induites par le collagène, avec pratiquement aucun effet sur le comptage ou les dimensions des plaquettes, et elle peut être utilisée seule ou avec un autre inhibiteur de l'agrégation des plaquettes. Ce dernier peut être aussi un agent biochimique dérivé des sangsues, tel qu'une apyrase, ou un inhibiteur de la libération du facteur d'agrégation des plaquettes par des leucocytes.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1987</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPBw9vfxcXR39dMNDnB19nTzdFZw9YuK9HVVCPcM8VAI8HEMcfVxDVFwdHcPcnV3DPH091Pw9PPwdPIEMwOC_ANcg0I8XYN5GFjTEnOKU3mhNDeDgptriLOHbmpBfnxqcUFicmpeakl8uL-FuYGBhZmBo6ExEUoA3C8s_A</recordid><startdate>19870212</startdate><enddate>19870212</enddate><creator>LEVY, HAIM</creator><creator>SAWYER, ROY, THOMAS</creator><creator>RIGBI, MEIR</creator><creator>IRAKI, FUAD</creator><scope>EVB</scope></search><sort><creationdate>19870212</creationdate><title>COLLAGEN-SPECIFIC ENZYME WITH PLATELET AGGREGATION INHIBITION PROPERTIES</title><author>LEVY, HAIM ; SAWYER, ROY, THOMAS ; RIGBI, MEIR ; IRAKI, FUAD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO8700860A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1987</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LEVY, HAIM</creatorcontrib><creatorcontrib>SAWYER, ROY, THOMAS</creatorcontrib><creatorcontrib>RIGBI, MEIR</creatorcontrib><creatorcontrib>IRAKI, FUAD</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEVY, HAIM</au><au>SAWYER, ROY, THOMAS</au><au>RIGBI, MEIR</au><au>IRAKI, FUAD</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COLLAGEN-SPECIFIC ENZYME WITH PLATELET AGGREGATION INHIBITION PROPERTIES</title><date>1987-02-12</date><risdate>1987</risdate><abstract>The collagenase is like tissue collagenases in that it cleaves collagen at a single site. The collagenase which has a molecular weight of about 50k daltons, specifically inhibits collagen-induced platelet aggregation, with substantially no effect on platelet count or size, and may be used alone or together with another platelet aggregation inhibitor. The latter may also be a leech-derived biochemical, such as an apyrase, or an inhibitor of the release of platelet aggregation factor by leucocytes.
La collagénase est comme les collagénases tissulaires dans la mesure où elle effectue le clivage du collagène en un seul site. La collagénase, qui possède un poids moléculaire d'environ 50k daltons, inhibe de manière spécifique l'agrégation des plaquettes induites par le collagène, avec pratiquement aucun effet sur le comptage ou les dimensions des plaquettes, et elle peut être utilisée seule ou avec un autre inhibiteur de l'agrégation des plaquettes. Ce dernier peut être aussi un agent biochimique dérivé des sangsues, tel qu'une apyrase, ou un inhibiteur de la libération du facteur d'agrégation des plaquettes par des leucocytes.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | COLLAGEN-SPECIFIC ENZYME WITH PLATELET AGGREGATION INHIBITION PROPERTIES |
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