CHEMICAL COMPOUNDS AND USES THEREOF

Disclosed herein are certain chemical compounds of Formula (I): that inhibit Werner Syndrome ATP dependent helicase enzyme (WRN) activity, in particular inhibit WRN helicase domain activity and are therefore useful in treating cancers treatable by inhibition of WRN, including cancers characterized b...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	JONES, Brian T, SANFORD, Amberly B, ALAM, Muzaffar, YU, Hongyi, PHELAN, James P, FLEURY, Melissa, BRNARDIC, Edward, TAYGERLY, Joshua P.G, DEMARTINO, Michael P, CAMPBELL, Kira A, VANHEYST, Michael D, MCFADDEN, Ryan M, LYNCH-COLAMETA, Tessa, LEISTER, Lara K, ROWLEY, Ann M, RYAN, Jonathon S, SEVERANCE, Daniel L, SIMONOVICH, Scott P
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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