CHEMICAL COMPOUNDS AND USES THEREOF
Disclosed herein are certain chemical compounds of Formula (I): that inhibit Werner Syndrome ATP dependent helicase enzyme (WRN) activity, in particular inhibit WRN helicase domain activity and are therefore useful in treating cancers treatable by inhibition of WRN, including cancers characterized b...
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| creator | JONES, Brian T SANFORD, Amberly B ALAM, Muzaffar YU, Hongyi PHELAN, James P FLEURY, Melissa BRNARDIC, Edward TAYGERLY, Joshua P.G DEMARTINO, Michael P CAMPBELL, Kira A VANHEYST, Michael D MCFADDEN, Ryan M LYNCH-COLAMETA, Tessa LEISTER, Lara K ROWLEY, Ann M RYAN, Jonathon S SEVERANCE, Daniel L SIMONOVICH, Scott P |
| description | Disclosed herein are certain chemical compounds of Formula (I): that inhibit Werner Syndrome ATP dependent helicase enzyme (WRN) activity, in particular inhibit WRN helicase domain activity and are therefore useful in treating cancers treatable by inhibition of WRN, including cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair system (dMMR). Also, disclosed are pharmaceutical compositions comprising such compounds, methods of using such compounds, and methods making the same.
L'invention concerne certains composés chimiques de formule (I) : qui inhibent l'activité de l'enzyme hélicase dépendante de l'ATP du syndrome de Werner (WRN), en particulier inhibent l'activité du domaine de l'hélicase WRN et sont par conséquent utiles dans le traitement de cancers pouvant être traités par inhibition de WRN, y compris des cancers caractérisés par une instabilité des microsatellites (MSI) et/ou un système de réparation de mésappariement d'ADN défectueuse (dMMR). L'invention concerne également des compositions pharmaceutiques comprenant de tels composés, des procédés d'utilisation de tels composés, et des procédés de fabrication de ceux-ci. |
| format | Patent |
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L'invention concerne certains composés chimiques de formule (I) : qui inhibent l'activité de l'enzyme hélicase dépendante de l'ATP du syndrome de Werner (WRN), en particulier inhibent l'activité du domaine de l'hélicase WRN et sont par conséquent utiles dans le traitement de cancers pouvant être traités par inhibition de WRN, y compris des cancers caractérisés par une instabilité des microsatellites (MSI) et/ou un système de réparation de mésappariement d'ADN défectueuse (dMMR). L'invention concerne également des compositions pharmaceutiques comprenant de tels composés, des procédés d'utilisation de tels composés, et des procédés de fabrication de ceux-ci.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241205&DB=EPODOC&CC=WO&NR=2024246862A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241205&DB=EPODOC&CC=WO&NR=2024246862A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JONES, Brian T</creatorcontrib><creatorcontrib>SANFORD, Amberly B</creatorcontrib><creatorcontrib>ALAM, Muzaffar</creatorcontrib><creatorcontrib>YU, Hongyi</creatorcontrib><creatorcontrib>PHELAN, James P</creatorcontrib><creatorcontrib>FLEURY, Melissa</creatorcontrib><creatorcontrib>BRNARDIC, Edward</creatorcontrib><creatorcontrib>TAYGERLY, Joshua P.G</creatorcontrib><creatorcontrib>DEMARTINO, Michael P</creatorcontrib><creatorcontrib>CAMPBELL, Kira A</creatorcontrib><creatorcontrib>VANHEYST, Michael D</creatorcontrib><creatorcontrib>MCFADDEN, Ryan M</creatorcontrib><creatorcontrib>LYNCH-COLAMETA, Tessa</creatorcontrib><creatorcontrib>LEISTER, Lara K</creatorcontrib><creatorcontrib>ROWLEY, Ann M</creatorcontrib><creatorcontrib>RYAN, Jonathon S</creatorcontrib><creatorcontrib>SEVERANCE, Daniel L</creatorcontrib><creatorcontrib>SIMONOVICH, Scott P</creatorcontrib><title>CHEMICAL COMPOUNDS AND USES THEREOF</title><description>Disclosed herein are certain chemical compounds of Formula (I): that inhibit Werner Syndrome ATP dependent helicase enzyme (WRN) activity, in particular inhibit WRN helicase domain activity and are therefore useful in treating cancers treatable by inhibition of WRN, including cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair system (dMMR). Also, disclosed are pharmaceutical compositions comprising such compounds, methods of using such compounds, and methods making the same.
L'invention concerne certains composés chimiques de formule (I) : qui inhibent l'activité de l'enzyme hélicase dépendante de l'ATP du syndrome de Werner (WRN), en particulier inhibent l'activité du domaine de l'hélicase WRN et sont par conséquent utiles dans le traitement de cancers pouvant être traités par inhibition de WRN, y compris des cancers caractérisés par une instabilité des microsatellites (MSI) et/ou un système de réparation de mésappariement d'ADN défectueuse (dMMR). L'invention concerne également des compositions pharmaceutiques comprenant de tels composés, des procédés d'utilisation de tels composés, et des procédés de fabrication de ceux-ci.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB29nD19XR29FFw9vcN8A_1cwlWcPRzUQgNdg1WCPFwDXL1d-NhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGRiZGJmYWZkaOhsbEqQIA2UojkA</recordid><startdate>20241205</startdate><enddate>20241205</enddate><creator>JONES, Brian T</creator><creator>SANFORD, Amberly B</creator><creator>ALAM, Muzaffar</creator><creator>YU, Hongyi</creator><creator>PHELAN, James P</creator><creator>FLEURY, Melissa</creator><creator>BRNARDIC, Edward</creator><creator>TAYGERLY, Joshua P.G</creator><creator>DEMARTINO, Michael P</creator><creator>CAMPBELL, Kira A</creator><creator>VANHEYST, Michael D</creator><creator>MCFADDEN, Ryan M</creator><creator>LYNCH-COLAMETA, Tessa</creator><creator>LEISTER, Lara K</creator><creator>ROWLEY, Ann M</creator><creator>RYAN, Jonathon S</creator><creator>SEVERANCE, Daniel L</creator><creator>SIMONOVICH, Scott P</creator><scope>EVB</scope></search><sort><creationdate>20241205</creationdate><title>CHEMICAL COMPOUNDS AND USES THEREOF</title><author>JONES, Brian T ; SANFORD, Amberly B ; ALAM, Muzaffar ; YU, Hongyi ; PHELAN, James P ; FLEURY, Melissa ; BRNARDIC, Edward ; TAYGERLY, Joshua P.G ; DEMARTINO, Michael P ; CAMPBELL, Kira A ; VANHEYST, Michael D ; MCFADDEN, Ryan M ; LYNCH-COLAMETA, Tessa ; LEISTER, Lara K ; ROWLEY, Ann M ; RYAN, Jonathon S ; SEVERANCE, Daniel L ; SIMONOVICH, Scott P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024246862A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JONES, Brian T</creatorcontrib><creatorcontrib>SANFORD, Amberly B</creatorcontrib><creatorcontrib>ALAM, Muzaffar</creatorcontrib><creatorcontrib>YU, Hongyi</creatorcontrib><creatorcontrib>PHELAN, James P</creatorcontrib><creatorcontrib>FLEURY, Melissa</creatorcontrib><creatorcontrib>BRNARDIC, Edward</creatorcontrib><creatorcontrib>TAYGERLY, Joshua P.G</creatorcontrib><creatorcontrib>DEMARTINO, Michael P</creatorcontrib><creatorcontrib>CAMPBELL, Kira A</creatorcontrib><creatorcontrib>VANHEYST, Michael D</creatorcontrib><creatorcontrib>MCFADDEN, Ryan M</creatorcontrib><creatorcontrib>LYNCH-COLAMETA, Tessa</creatorcontrib><creatorcontrib>LEISTER, Lara K</creatorcontrib><creatorcontrib>ROWLEY, Ann M</creatorcontrib><creatorcontrib>RYAN, Jonathon S</creatorcontrib><creatorcontrib>SEVERANCE, Daniel L</creatorcontrib><creatorcontrib>SIMONOVICH, Scott P</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JONES, Brian T</au><au>SANFORD, Amberly B</au><au>ALAM, Muzaffar</au><au>YU, Hongyi</au><au>PHELAN, James P</au><au>FLEURY, Melissa</au><au>BRNARDIC, Edward</au><au>TAYGERLY, Joshua P.G</au><au>DEMARTINO, Michael P</au><au>CAMPBELL, Kira A</au><au>VANHEYST, Michael D</au><au>MCFADDEN, Ryan M</au><au>LYNCH-COLAMETA, Tessa</au><au>LEISTER, Lara K</au><au>ROWLEY, Ann M</au><au>RYAN, Jonathon S</au><au>SEVERANCE, Daniel L</au><au>SIMONOVICH, Scott P</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CHEMICAL COMPOUNDS AND USES THEREOF</title><date>2024-12-05</date><risdate>2024</risdate><abstract>Disclosed herein are certain chemical compounds of Formula (I): that inhibit Werner Syndrome ATP dependent helicase enzyme (WRN) activity, in particular inhibit WRN helicase domain activity and are therefore useful in treating cancers treatable by inhibition of WRN, including cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair system (dMMR). Also, disclosed are pharmaceutical compositions comprising such compounds, methods of using such compounds, and methods making the same.
L'invention concerne certains composés chimiques de formule (I) : qui inhibent l'activité de l'enzyme hélicase dépendante de l'ATP du syndrome de Werner (WRN), en particulier inhibent l'activité du domaine de l'hélicase WRN et sont par conséquent utiles dans le traitement de cancers pouvant être traités par inhibition de WRN, y compris des cancers caractérisés par une instabilité des microsatellites (MSI) et/ou un système de réparation de mésappariement d'ADN défectueuse (dMMR). L'invention concerne également des compositions pharmaceutiques comprenant de tels composés, des procédés d'utilisation de tels composés, et des procédés de fabrication de ceux-ci.</abstract><oa>free_for_read</oa></addata></record> |
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| title | CHEMICAL COMPOUNDS AND USES THEREOF |
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