CYP26B1 INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF
The present disclosure provides compounds and pharmaceutically acceptable salts thereof for inhibiting CYP26B1. Aspects of the present disclosure also include methods of using the compounds to treat diseases or disorders, including, but not limited to, skin disorders, cancer, neurological disorders,...
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| creator | HSIEH, Tom Han Hsiao LASSUEUR, Kristiana ARNS, Stephen Paul PERSAUD, Rosanne RULLO, Jacob STURINO, Claudio CAMERON, Donald Andrew PENNIMPEDE, Tracie Lena PETKOVICH, Martin MANCINI, Joseph A MARTINO, Giovanni SZYCHOWSKI, Janek TAN, Jason Samuel |
| description | The present disclosure provides compounds and pharmaceutically acceptable salts thereof for inhibiting CYP26B1. Aspects of the present disclosure also include methods of using the compounds to treat diseases or disorders, including, but not limited to, skin disorders, cancer, neurological disorders, heterotopic ossification (HO), fibrodysplasia ossificans progressiva (FOP), multiple osteochondromas, and diseases or disorders of the eye, including meibomian gland dysfunction and dry eye disease.
La présente invention concerne des composés et des sels pharmaceutiquement acceptables de ceux-ci pour inhiber CYP26B1. Des aspects de la présente invention comprennent également des procédés d'utilisation des composés pour traiter des maladies ou des troubles, comprenant, mais sans y être limités, des troubles cutanés, le cancer, des troubles neurologiques, l'ossification hétérotopique (HO), la fibrodysplasie ossifiante progressive (FOP), de multiples ostéochondromes, et des maladies ou des troubles de l'oeil, y compris un dysfonctionnement de la glande de Meibomius et le syndrome de l'oeil sec. |
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La présente invention concerne des composés et des sels pharmaceutiquement acceptables de ceux-ci pour inhiber CYP26B1. Des aspects de la présente invention comprennent également des procédés d'utilisation des composés pour traiter des maladies ou des troubles, comprenant, mais sans y être limités, des troubles cutanés, le cancer, des troubles neurologiques, l'ossification hétérotopique (HO), la fibrodysplasie ossifiante progressive (FOP), de multiples ostéochondromes, et des maladies ou des troubles de l'oeil, y compris un dysfonctionnement de la glande de Meibomius et le syndrome de l'oeil sec.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241205&DB=EPODOC&CC=WO&NR=2024243693A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241205&DB=EPODOC&CC=WO&NR=2024243693A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HSIEH, Tom Han Hsiao</creatorcontrib><creatorcontrib>LASSUEUR, Kristiana</creatorcontrib><creatorcontrib>ARNS, Stephen Paul</creatorcontrib><creatorcontrib>PERSAUD, Rosanne</creatorcontrib><creatorcontrib>RULLO, Jacob</creatorcontrib><creatorcontrib>STURINO, Claudio</creatorcontrib><creatorcontrib>CAMERON, Donald Andrew</creatorcontrib><creatorcontrib>PENNIMPEDE, Tracie Lena</creatorcontrib><creatorcontrib>PETKOVICH, Martin</creatorcontrib><creatorcontrib>MANCINI, Joseph A</creatorcontrib><creatorcontrib>MARTINO, Giovanni</creatorcontrib><creatorcontrib>SZYCHOWSKI, Janek</creatorcontrib><creatorcontrib>TAN, Jason Samuel</creatorcontrib><title>CYP26B1 INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF</title><description>The present disclosure provides compounds and pharmaceutically acceptable salts thereof for inhibiting CYP26B1. Aspects of the present disclosure also include methods of using the compounds to treat diseases or disorders, including, but not limited to, skin disorders, cancer, neurological disorders, heterotopic ossification (HO), fibrodysplasia ossificans progressiva (FOP), multiple osteochondromas, and diseases or disorders of the eye, including meibomian gland dysfunction and dry eye disease.
La présente invention concerne des composés et des sels pharmaceutiquement acceptables de ceux-ci pour inhiber CYP26B1. Des aspects de la présente invention comprennent également des procédés d'utilisation des composés pour traiter des maladies ou des troubles, comprenant, mais sans y être limités, des troubles cutanés, le cancer, des troubles neurologiques, l'ossification hétérotopique (HO), la fibrodysplasie ossifiante progressive (FOP), de multiples ostéochondromes, et des maladies ou des troubles de l'oeil, y compris un dysfonctionnement de la glande de Meibomius et le syndrome de l'oeil sec.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDBzjgwwMnMyVPD08_B08gzxD1Jw9vcN8A_1cwlWcPRzUfB1DfHwB7L93RRCg10VQjxcg1z93XgYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXy4v5GBkYmRibGZpbGjoTFxqgCOGCiQ</recordid><startdate>20241205</startdate><enddate>20241205</enddate><creator>HSIEH, Tom Han Hsiao</creator><creator>LASSUEUR, Kristiana</creator><creator>ARNS, Stephen Paul</creator><creator>PERSAUD, Rosanne</creator><creator>RULLO, Jacob</creator><creator>STURINO, Claudio</creator><creator>CAMERON, Donald Andrew</creator><creator>PENNIMPEDE, Tracie Lena</creator><creator>PETKOVICH, Martin</creator><creator>MANCINI, Joseph A</creator><creator>MARTINO, Giovanni</creator><creator>SZYCHOWSKI, Janek</creator><creator>TAN, Jason Samuel</creator><scope>EVB</scope></search><sort><creationdate>20241205</creationdate><title>CYP26B1 INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF</title><author>HSIEH, Tom Han Hsiao ; LASSUEUR, Kristiana ; ARNS, Stephen Paul ; PERSAUD, Rosanne ; RULLO, Jacob ; STURINO, Claudio ; CAMERON, Donald Andrew ; PENNIMPEDE, Tracie Lena ; PETKOVICH, Martin ; MANCINI, Joseph A ; MARTINO, Giovanni ; SZYCHOWSKI, Janek ; TAN, Jason Samuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024243693A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>HSIEH, Tom Han Hsiao</creatorcontrib><creatorcontrib>LASSUEUR, Kristiana</creatorcontrib><creatorcontrib>ARNS, Stephen Paul</creatorcontrib><creatorcontrib>PERSAUD, Rosanne</creatorcontrib><creatorcontrib>RULLO, Jacob</creatorcontrib><creatorcontrib>STURINO, Claudio</creatorcontrib><creatorcontrib>CAMERON, Donald Andrew</creatorcontrib><creatorcontrib>PENNIMPEDE, Tracie Lena</creatorcontrib><creatorcontrib>PETKOVICH, Martin</creatorcontrib><creatorcontrib>MANCINI, Joseph A</creatorcontrib><creatorcontrib>MARTINO, Giovanni</creatorcontrib><creatorcontrib>SZYCHOWSKI, Janek</creatorcontrib><creatorcontrib>TAN, Jason Samuel</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HSIEH, Tom Han Hsiao</au><au>LASSUEUR, Kristiana</au><au>ARNS, Stephen Paul</au><au>PERSAUD, Rosanne</au><au>RULLO, Jacob</au><au>STURINO, Claudio</au><au>CAMERON, Donald Andrew</au><au>PENNIMPEDE, Tracie Lena</au><au>PETKOVICH, Martin</au><au>MANCINI, Joseph A</au><au>MARTINO, Giovanni</au><au>SZYCHOWSKI, Janek</au><au>TAN, Jason Samuel</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CYP26B1 INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF</title><date>2024-12-05</date><risdate>2024</risdate><abstract>The present disclosure provides compounds and pharmaceutically acceptable salts thereof for inhibiting CYP26B1. Aspects of the present disclosure also include methods of using the compounds to treat diseases or disorders, including, but not limited to, skin disorders, cancer, neurological disorders, heterotopic ossification (HO), fibrodysplasia ossificans progressiva (FOP), multiple osteochondromas, and diseases or disorders of the eye, including meibomian gland dysfunction and dry eye disease.
La présente invention concerne des composés et des sels pharmaceutiquement acceptables de ceux-ci pour inhiber CYP26B1. Des aspects de la présente invention comprennent également des procédés d'utilisation des composés pour traiter des maladies ou des troubles, comprenant, mais sans y être limités, des troubles cutanés, le cancer, des troubles neurologiques, l'ossification hétérotopique (HO), la fibrodysplasie ossifiante progressive (FOP), de multiples ostéochondromes, et des maladies ou des troubles de l'oeil, y compris un dysfonctionnement de la glande de Meibomius et le syndrome de l'oeil sec.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | CYP26B1 INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF |
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