REVERSE TRANSCRIPTASE WITH IMPROVED PROPERTIES
The present invention relates to reverse transcriptase enzymes comprising a modified Moloney Murine Leukaemia Virus reverse transcriptase amino acid sequence, wherein said amino acid sequence comprises a mutation compared to the wild-type Moloney Murine Leukaemia Virus reverse transcriptase, and sai...
Gespeichert in:
Hauptverfasser: | , , |
---|---|
Format: | Patent |
Sprache: | eng ; fre |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | |
container_start_page | |
container_title | |
container_volume | |
creator | RIMSELIENE, Renata ZVIRBLIENE, Marija VIRKUTIS, Jonas |
description | The present invention relates to reverse transcriptase enzymes comprising a modified Moloney Murine Leukaemia Virus reverse transcriptase amino acid sequence, wherein said amino acid sequence comprises a mutation compared to the wild-type Moloney Murine Leukaemia Virus reverse transcriptase, and said enzyme possesses increased inhibitor resistance compared to the wild-type Moloney Murine Leukaemia Virus reverse transcriptase. The present invention also relates to compositions, reaction mixtures, and kits comprising the said reverse transcriptase enzymes are used to synthesize cDNA from RNA.
La présente invention concerne des enzymes de transcriptase inverse comprenant une séquence d'acides aminés de la transcriptase inverse du virus de la leucémie murine de Moloney modifiée, ladite séquence d'acides aminés contenant une mutation par comparaison avec la transcriptase inverse du virus de la leucémie murine de Moloney de type sauvage, et ladite enzyme possède une résistance accrue aux inhibiteurs par comparaison avec la transcriptase inverse du virus de la leucémie murine de Moloney de type sauvage. La présente invention concerne également des compositions, des mélanges réactionnels et des kits contenant lesdites enzymes de transcriptase inverse étant utilisés pour synthétiser l'ADNc à partir de l'ARN. |
format | Patent |
fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2024240781A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2024240781A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2024240781A13</originalsourceid><addsrcrecordid>eNrjZNALcg1zDQp2VQgJcvQLdg7yDAhxBPLCPUM8FDx9A4L8w1xdFIBUgGtQiKdrMA8Da1piTnEqL5TmZlB2cw1x9tBNLciPTy0uSExOzUstiQ_3NzIwMjEyMTC3MHQ0NCZOFQC3sCcv</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>REVERSE TRANSCRIPTASE WITH IMPROVED PROPERTIES</title><source>esp@cenet</source><creator>RIMSELIENE, Renata ; ZVIRBLIENE, Marija ; VIRKUTIS, Jonas</creator><creatorcontrib>RIMSELIENE, Renata ; ZVIRBLIENE, Marija ; VIRKUTIS, Jonas</creatorcontrib><description>The present invention relates to reverse transcriptase enzymes comprising a modified Moloney Murine Leukaemia Virus reverse transcriptase amino acid sequence, wherein said amino acid sequence comprises a mutation compared to the wild-type Moloney Murine Leukaemia Virus reverse transcriptase, and said enzyme possesses increased inhibitor resistance compared to the wild-type Moloney Murine Leukaemia Virus reverse transcriptase. The present invention also relates to compositions, reaction mixtures, and kits comprising the said reverse transcriptase enzymes are used to synthesize cDNA from RNA.
La présente invention concerne des enzymes de transcriptase inverse comprenant une séquence d'acides aminés de la transcriptase inverse du virus de la leucémie murine de Moloney modifiée, ladite séquence d'acides aminés contenant une mutation par comparaison avec la transcriptase inverse du virus de la leucémie murine de Moloney de type sauvage, et ladite enzyme possède une résistance accrue aux inhibiteurs par comparaison avec la transcriptase inverse du virus de la leucémie murine de Moloney de type sauvage. La présente invention concerne également des compositions, des mélanges réactionnels et des kits contenant lesdites enzymes de transcriptase inverse étant utilisés pour synthétiser l'ADNc à partir de l'ARN.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241128&DB=EPODOC&CC=WO&NR=2024240781A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241128&DB=EPODOC&CC=WO&NR=2024240781A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RIMSELIENE, Renata</creatorcontrib><creatorcontrib>ZVIRBLIENE, Marija</creatorcontrib><creatorcontrib>VIRKUTIS, Jonas</creatorcontrib><title>REVERSE TRANSCRIPTASE WITH IMPROVED PROPERTIES</title><description>The present invention relates to reverse transcriptase enzymes comprising a modified Moloney Murine Leukaemia Virus reverse transcriptase amino acid sequence, wherein said amino acid sequence comprises a mutation compared to the wild-type Moloney Murine Leukaemia Virus reverse transcriptase, and said enzyme possesses increased inhibitor resistance compared to the wild-type Moloney Murine Leukaemia Virus reverse transcriptase. The present invention also relates to compositions, reaction mixtures, and kits comprising the said reverse transcriptase enzymes are used to synthesize cDNA from RNA.
La présente invention concerne des enzymes de transcriptase inverse comprenant une séquence d'acides aminés de la transcriptase inverse du virus de la leucémie murine de Moloney modifiée, ladite séquence d'acides aminés contenant une mutation par comparaison avec la transcriptase inverse du virus de la leucémie murine de Moloney de type sauvage, et ladite enzyme possède une résistance accrue aux inhibiteurs par comparaison avec la transcriptase inverse du virus de la leucémie murine de Moloney de type sauvage. La présente invention concerne également des compositions, des mélanges réactionnels et des kits contenant lesdites enzymes de transcriptase inverse étant utilisés pour synthétiser l'ADNc à partir de l'ARN.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNALcg1zDQp2VQgJcvQLdg7yDAhxBPLCPUM8FDx9A4L8w1xdFIBUgGtQiKdrMA8Da1piTnEqL5TmZlB2cw1x9tBNLciPTy0uSExOzUstiQ_3NzIwMjEyMTC3MHQ0NCZOFQC3sCcv</recordid><startdate>20241128</startdate><enddate>20241128</enddate><creator>RIMSELIENE, Renata</creator><creator>ZVIRBLIENE, Marija</creator><creator>VIRKUTIS, Jonas</creator><scope>EVB</scope></search><sort><creationdate>20241128</creationdate><title>REVERSE TRANSCRIPTASE WITH IMPROVED PROPERTIES</title><author>RIMSELIENE, Renata ; ZVIRBLIENE, Marija ; VIRKUTIS, Jonas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024240781A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>RIMSELIENE, Renata</creatorcontrib><creatorcontrib>ZVIRBLIENE, Marija</creatorcontrib><creatorcontrib>VIRKUTIS, Jonas</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RIMSELIENE, Renata</au><au>ZVIRBLIENE, Marija</au><au>VIRKUTIS, Jonas</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>REVERSE TRANSCRIPTASE WITH IMPROVED PROPERTIES</title><date>2024-11-28</date><risdate>2024</risdate><abstract>The present invention relates to reverse transcriptase enzymes comprising a modified Moloney Murine Leukaemia Virus reverse transcriptase amino acid sequence, wherein said amino acid sequence comprises a mutation compared to the wild-type Moloney Murine Leukaemia Virus reverse transcriptase, and said enzyme possesses increased inhibitor resistance compared to the wild-type Moloney Murine Leukaemia Virus reverse transcriptase. The present invention also relates to compositions, reaction mixtures, and kits comprising the said reverse transcriptase enzymes are used to synthesize cDNA from RNA.
La présente invention concerne des enzymes de transcriptase inverse comprenant une séquence d'acides aminés de la transcriptase inverse du virus de la leucémie murine de Moloney modifiée, ladite séquence d'acides aminés contenant une mutation par comparaison avec la transcriptase inverse du virus de la leucémie murine de Moloney de type sauvage, et ladite enzyme possède une résistance accrue aux inhibiteurs par comparaison avec la transcriptase inverse du virus de la leucémie murine de Moloney de type sauvage. La présente invention concerne également des compositions, des mélanges réactionnels et des kits contenant lesdites enzymes de transcriptase inverse étant utilisés pour synthétiser l'ADNc à partir de l'ARN.</abstract><oa>free_for_read</oa></addata></record> |
fulltext | fulltext_linktorsrc |
identifier | |
ispartof | |
issn | |
language | eng ; fre |
recordid | cdi_epo_espacenet_WO2024240781A1 |
source | esp@cenet |
subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
title | REVERSE TRANSCRIPTASE WITH IMPROVED PROPERTIES |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T15%3A03%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=RIMSELIENE,%20Renata&rft.date=2024-11-28&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2024240781A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |