COMPOSITIONS AND METHODS FOR ENGINEERING MATURE IPSC-DERIVED AND ESC-DERIVED HEPATOCYTES
Disclosed herein are compositions and methods for inducing differentiation of an induced pluripotent stem cell (iPSC) or an embryonic stem cell (ESC) into a hepatocyte. The compositions and methods may also be used to promote maturation of a hepatocyte. The compositions and methods may include modul...
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| description | Disclosed herein are compositions and methods for inducing differentiation of an induced pluripotent stem cell (iPSC) or an embryonic stem cell (ESC) into a hepatocyte. The compositions and methods may also be used to promote maturation of a hepatocyte. The compositions and methods may include modulators of a gene selected from NHLH2, KLF7, GSC2, PPARG, SALL4, ESRRG, ESRRB, SMAD2, KLF6, TCF7, SMARCA2, SMAD3, TFEC, PURB, ZNF398, ASCL2, NFIB, ZIC4, ZNF618, FOXA2, NR5A1, FOXA3, HNF4A, HNF4G, HBP1, NHLH1, NR5A2, or YAF2, or a combination thereof, or a gene product thereof. The compositions and methods may be used for liver transplantations.
L'invention concerne des compositions et des procédés d'induction de la différenciation d'une cellule souche pluripotente induite (iPSC) ou d'une cellule souche embryonnaire (ESC) dans un hépatocyte. Les compositions et les procédés peuvent également être utilisés pour favoriser la maturation d'un hépatocyte. Les compositions et les procédés peuvent comprendre des modulateurs d'un gène choisi parmi NHLH2, KLF7, GSC2, PPARG, SALL4, ESRRG, ESRRB, SMAD2, KLF6, TCF7, SMARCA2, SMAD3, TFEC, PURB, ZNF398, ASCL2, NFIB, ZIC4, ZNF618, FOXA2, NR5A1, FOXA3, HNF4A, HNF4G, HBP1, NHLH1, NR5A2, ou YAF2, ou une combinaison de ceux-ci, ou un produit génique de ceux-ci. Les compositions et les procédés peuvent être utilisés pour des transplantations de foie. |
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L'invention concerne des compositions et des procédés d'induction de la différenciation d'une cellule souche pluripotente induite (iPSC) ou d'une cellule souche embryonnaire (ESC) dans un hépatocyte. Les compositions et les procédés peuvent également être utilisés pour favoriser la maturation d'un hépatocyte. Les compositions et les procédés peuvent comprendre des modulateurs d'un gène choisi parmi NHLH2, KLF7, GSC2, PPARG, SALL4, ESRRG, ESRRB, SMAD2, KLF6, TCF7, SMARCA2, SMAD3, TFEC, PURB, ZNF398, ASCL2, NFIB, ZIC4, ZNF618, FOXA2, NR5A1, FOXA3, HNF4A, HNF4G, HBP1, NHLH1, NR5A2, ou YAF2, ou une combinaison de ceux-ci, ou un produit génique de ceux-ci. Les compositions et les procédés peuvent être utilisés pour des transplantations de foie.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241107&DB=EPODOC&CC=WO&NR=2024229292A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241107&DB=EPODOC&CC=WO&NR=2024229292A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GERSBACH, Charles A</creatorcontrib><creatorcontrib>STREFF, Helen</creatorcontrib><title>COMPOSITIONS AND METHODS FOR ENGINEERING MATURE IPSC-DERIVED AND ESC-DERIVED HEPATOCYTES</title><description>Disclosed herein are compositions and methods for inducing differentiation of an induced pluripotent stem cell (iPSC) or an embryonic stem cell (ESC) into a hepatocyte. The compositions and methods may also be used to promote maturation of a hepatocyte. The compositions and methods may include modulators of a gene selected from NHLH2, KLF7, GSC2, PPARG, SALL4, ESRRG, ESRRB, SMAD2, KLF6, TCF7, SMARCA2, SMAD3, TFEC, PURB, ZNF398, ASCL2, NFIB, ZIC4, ZNF618, FOXA2, NR5A1, FOXA3, HNF4A, HNF4G, HBP1, NHLH1, NR5A2, or YAF2, or a combination thereof, or a gene product thereof. The compositions and methods may be used for liver transplantations.
L'invention concerne des compositions et des procédés d'induction de la différenciation d'une cellule souche pluripotente induite (iPSC) ou d'une cellule souche embryonnaire (ESC) dans un hépatocyte. Les compositions et les procédés peuvent également être utilisés pour favoriser la maturation d'un hépatocyte. Les compositions et les procédés peuvent comprendre des modulateurs d'un gène choisi parmi NHLH2, KLF7, GSC2, PPARG, SALL4, ESRRG, ESRRB, SMAD2, KLF6, TCF7, SMARCA2, SMAD3, TFEC, PURB, ZNF398, ASCL2, NFIB, ZIC4, ZNF618, FOXA2, NR5A1, FOXA3, HNF4A, HNF4G, HBP1, NHLH1, NR5A2, ou YAF2, ou une combinaison de ceux-ci, ou un produit génique de ceux-ci. Les compositions et les procédés peuvent être utilisés pour des transplantations de foie.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIhw9vcN8A_2DPH09wtWcPRzUfB1DfHwdwlWcPMPUnD1c_f0c3UN8vRzV_B1DAkNclXwDAh21nUBCoW5uoDVuyLxPVwDHEP8nSNDXIN5GFjTEnOKU3mhNDeDsptriLOHbmpBfnxqcUFicmpeakl8uL-RgZGJkZElEDoaGROnCgDIYTJJ</recordid><startdate>20241107</startdate><enddate>20241107</enddate><creator>GERSBACH, Charles A</creator><creator>STREFF, Helen</creator><scope>EVB</scope></search><sort><creationdate>20241107</creationdate><title>COMPOSITIONS AND METHODS FOR ENGINEERING MATURE IPSC-DERIVED AND ESC-DERIVED HEPATOCYTES</title><author>GERSBACH, Charles A ; STREFF, Helen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024229292A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>GERSBACH, Charles A</creatorcontrib><creatorcontrib>STREFF, Helen</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GERSBACH, Charles A</au><au>STREFF, Helen</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITIONS AND METHODS FOR ENGINEERING MATURE IPSC-DERIVED AND ESC-DERIVED HEPATOCYTES</title><date>2024-11-07</date><risdate>2024</risdate><abstract>Disclosed herein are compositions and methods for inducing differentiation of an induced pluripotent stem cell (iPSC) or an embryonic stem cell (ESC) into a hepatocyte. The compositions and methods may also be used to promote maturation of a hepatocyte. The compositions and methods may include modulators of a gene selected from NHLH2, KLF7, GSC2, PPARG, SALL4, ESRRG, ESRRB, SMAD2, KLF6, TCF7, SMARCA2, SMAD3, TFEC, PURB, ZNF398, ASCL2, NFIB, ZIC4, ZNF618, FOXA2, NR5A1, FOXA3, HNF4A, HNF4G, HBP1, NHLH1, NR5A2, or YAF2, or a combination thereof, or a gene product thereof. The compositions and methods may be used for liver transplantations.
L'invention concerne des compositions et des procédés d'induction de la différenciation d'une cellule souche pluripotente induite (iPSC) ou d'une cellule souche embryonnaire (ESC) dans un hépatocyte. Les compositions et les procédés peuvent également être utilisés pour favoriser la maturation d'un hépatocyte. Les compositions et les procédés peuvent comprendre des modulateurs d'un gène choisi parmi NHLH2, KLF7, GSC2, PPARG, SALL4, ESRRG, ESRRB, SMAD2, KLF6, TCF7, SMARCA2, SMAD3, TFEC, PURB, ZNF398, ASCL2, NFIB, ZIC4, ZNF618, FOXA2, NR5A1, FOXA3, HNF4A, HNF4G, HBP1, NHLH1, NR5A2, ou YAF2, ou une combinaison de ceux-ci, ou un produit génique de ceux-ci. Les compositions et les procédés peuvent être utilisés pour des transplantations de foie.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | COMPOSITIONS AND METHODS FOR ENGINEERING MATURE IPSC-DERIVED AND ESC-DERIVED HEPATOCYTES |
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