A PHARMACEUTICAL COMPOSITION COMPRISING 17-AAG AND STAUROSPORINE FOR USE IN THE PREVENTION OR TREATMENT OF CANCER AND DISEASES RESULTING FROM EXCESSIVE CELL PROLIFERATION AND A POLYMER- LIPID NANOPARTICLE CONTAINING THE COMPOSITION
The description of the invention discloses a composition comprising 17- AAG and staurosporine for use in the treatment of melanoma, non-small cell lung cancer, pancreatic cancer, mammary gland tumours or gliomas, and a stable polymer-lipid nanoparticle for drug binding and delivery, consisting of a...
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| creator | ŁABĘDŹ, Natalia WIETRZYK, Joanna SMOROŃ, Wojciech MAĆKIEWICZ, Rafał PIOTROWSKA, Weronika PSURSKI, Mateusz WITEK, Julia SWIĘCH, Olga |
| description | The description of the invention discloses a composition comprising 17- AAG and staurosporine for use in the treatment of melanoma, non-small cell lung cancer, pancreatic cancer, mammary gland tumours or gliomas, and a stable polymer-lipid nanoparticle for drug binding and delivery, consisting of a core containing polylactic-co-glycolic acid (PLGA) and polyvinyl alcohol (PVA) and a core envelope containing a mixture of lipids: 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DDPC), cholesterol and the ammonium salt 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N - [amino(polyethylene glycol)-2000 (DSPE-PEG(2000)NH2J.
La description de l'invention concerne une composition comprenant de la 17-AAG et de la staurosporine pour une utilisation dans le traitement d'un mélanome, d'un cancer du poumon non à petites cellules, d'un cancer du pancréas, de tumeurs de glande mammaire ou de gliomes, et une nanoparticule polymère-lipide stable destinée à la liaison et l'administration de médicament, consistant en un noyau contenant de l'acide polylactique-co-glycolique (PLGA) et de l'alcool polyvinylique (PVA) et une enveloppe de noyau contenant un mélange de lipides : la 1,2-dipalmitoyl-sn-glycéro-3-phosphocholine (DDPC), le cholestérol et le sel d'ammonium 1,2-distéaroyl-sn-glycéro-3-phosphoéthanolamine-N-[amino(polyéthylène glycol)-2000 (DSPE-PEG(2000)NH2J. |
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La description de l'invention concerne une composition comprenant de la 17-AAG et de la staurosporine pour une utilisation dans le traitement d'un mélanome, d'un cancer du poumon non à petites cellules, d'un cancer du pancréas, de tumeurs de glande mammaire ou de gliomes, et une nanoparticule polymère-lipide stable destinée à la liaison et l'administration de médicament, consistant en un noyau contenant de l'acide polylactique-co-glycolique (PLGA) et de l'alcool polyvinylique (PVA) et une enveloppe de noyau contenant un mélange de lipides : la 1,2-dipalmitoyl-sn-glycéro-3-phosphocholine (DDPC), le cholestérol et le sel d'ammonium 1,2-distéaroyl-sn-glycéro-3-phosphoéthanolamine-N-[amino(polyéthylène glycol)-2000 (DSPE-PEG(2000)NH2J.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241107&DB=EPODOC&CC=WO&NR=2024228630A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241107&DB=EPODOC&CC=WO&NR=2024228630A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ŁABĘDŹ, Natalia</creatorcontrib><creatorcontrib>WIETRZYK, Joanna</creatorcontrib><creatorcontrib>SMOROŃ, Wojciech</creatorcontrib><creatorcontrib>MAĆKIEWICZ, Rafał</creatorcontrib><creatorcontrib>PIOTROWSKA, Weronika</creatorcontrib><creatorcontrib>PSURSKI, Mateusz</creatorcontrib><creatorcontrib>WITEK, Julia</creatorcontrib><creatorcontrib>SWIĘCH, Olga</creatorcontrib><title>A PHARMACEUTICAL COMPOSITION COMPRISING 17-AAG AND STAUROSPORINE FOR USE IN THE PREVENTION OR TREATMENT OF CANCER AND DISEASES RESULTING FROM EXCESSIVE CELL PROLIFERATION AND A POLYMER- LIPID NANOPARTICLE CONTAINING THE COMPOSITION</title><description>The description of the invention discloses a composition comprising 17- AAG and staurosporine for use in the treatment of melanoma, non-small cell lung cancer, pancreatic cancer, mammary gland tumours or gliomas, and a stable polymer-lipid nanoparticle for drug binding and delivery, consisting of a core containing polylactic-co-glycolic acid (PLGA) and polyvinyl alcohol (PVA) and a core envelope containing a mixture of lipids: 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DDPC), cholesterol and the ammonium salt 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N - [amino(polyethylene glycol)-2000 (DSPE-PEG(2000)NH2J.
La description de l'invention concerne une composition comprenant de la 17-AAG et de la staurosporine pour une utilisation dans le traitement d'un mélanome, d'un cancer du poumon non à petites cellules, d'un cancer du pancréas, de tumeurs de glande mammaire ou de gliomes, et une nanoparticule polymère-lipide stable destinée à la liaison et l'administration de médicament, consistant en un noyau contenant de l'acide polylactique-co-glycolique (PLGA) et de l'alcool polyvinylique (PVA) et une enveloppe de noyau contenant un mélange de lipides : la 1,2-dipalmitoyl-sn-glycéro-3-phosphocholine (DDPC), le cholestérol et le sel d'ammonium 1,2-distéaroyl-sn-glycéro-3-phosphoéthanolamine-N-[amino(polyéthylène glycol)-2000 (DSPE-PEG(2000)NH2J.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNj7FOw0AMhrMwIOAdLDFHalMErNbFaSxd7JN9Ke1UVShMCCqVd-Y1uEQMjEy2Zf_f__u6-kZIPdqAgcbMASMEHZI6Z1ZZemNn2cL6qUbcAkoLnnE09aTGQtCpwegELJB7gmS0I1nUZZGNMA9lBu0goASyBdGyEzo5GPkY82zQmQ5A-0DuvCMIFGOBaeSODBfeLCxxNR4GshoiJ25BUDShleyxiFQyssy4OcufV26rq7fT-2W6-6031X1HOfT1dP48Tpfz6XX6mL6OL9qsmoemeX7crHC9-d_VD6sJWWI</recordid><startdate>20241107</startdate><enddate>20241107</enddate><creator>ŁABĘDŹ, Natalia</creator><creator>WIETRZYK, Joanna</creator><creator>SMOROŃ, Wojciech</creator><creator>MAĆKIEWICZ, Rafał</creator><creator>PIOTROWSKA, Weronika</creator><creator>PSURSKI, Mateusz</creator><creator>WITEK, Julia</creator><creator>SWIĘCH, Olga</creator><scope>EVB</scope></search><sort><creationdate>20241107</creationdate><title>A PHARMACEUTICAL COMPOSITION COMPRISING 17-AAG AND STAUROSPORINE FOR USE IN THE PREVENTION OR TREATMENT OF CANCER AND DISEASES RESULTING FROM EXCESSIVE CELL PROLIFERATION AND A POLYMER- LIPID NANOPARTICLE CONTAINING THE COMPOSITION</title><author>ŁABĘDŹ, Natalia ; WIETRZYK, Joanna ; SMOROŃ, Wojciech ; MAĆKIEWICZ, Rafał ; PIOTROWSKA, Weronika ; PSURSKI, Mateusz ; WITEK, Julia ; SWIĘCH, Olga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024228630A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ŁABĘDŹ, Natalia</creatorcontrib><creatorcontrib>WIETRZYK, Joanna</creatorcontrib><creatorcontrib>SMOROŃ, Wojciech</creatorcontrib><creatorcontrib>MAĆKIEWICZ, Rafał</creatorcontrib><creatorcontrib>PIOTROWSKA, Weronika</creatorcontrib><creatorcontrib>PSURSKI, Mateusz</creatorcontrib><creatorcontrib>WITEK, Julia</creatorcontrib><creatorcontrib>SWIĘCH, Olga</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ŁABĘDŹ, Natalia</au><au>WIETRZYK, Joanna</au><au>SMOROŃ, Wojciech</au><au>MAĆKIEWICZ, Rafał</au><au>PIOTROWSKA, Weronika</au><au>PSURSKI, Mateusz</au><au>WITEK, Julia</au><au>SWIĘCH, Olga</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A PHARMACEUTICAL COMPOSITION COMPRISING 17-AAG AND STAUROSPORINE FOR USE IN THE PREVENTION OR TREATMENT OF CANCER AND DISEASES RESULTING FROM EXCESSIVE CELL PROLIFERATION AND A POLYMER- LIPID NANOPARTICLE CONTAINING THE COMPOSITION</title><date>2024-11-07</date><risdate>2024</risdate><abstract>The description of the invention discloses a composition comprising 17- AAG and staurosporine for use in the treatment of melanoma, non-small cell lung cancer, pancreatic cancer, mammary gland tumours or gliomas, and a stable polymer-lipid nanoparticle for drug binding and delivery, consisting of a core containing polylactic-co-glycolic acid (PLGA) and polyvinyl alcohol (PVA) and a core envelope containing a mixture of lipids: 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DDPC), cholesterol and the ammonium salt 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N - [amino(polyethylene glycol)-2000 (DSPE-PEG(2000)NH2J.
La description de l'invention concerne une composition comprenant de la 17-AAG et de la staurosporine pour une utilisation dans le traitement d'un mélanome, d'un cancer du poumon non à petites cellules, d'un cancer du pancréas, de tumeurs de glande mammaire ou de gliomes, et une nanoparticule polymère-lipide stable destinée à la liaison et l'administration de médicament, consistant en un noyau contenant de l'acide polylactique-co-glycolique (PLGA) et de l'alcool polyvinylique (PVA) et une enveloppe de noyau contenant un mélange de lipides : la 1,2-dipalmitoyl-sn-glycéro-3-phosphocholine (DDPC), le cholestérol et le sel d'ammonium 1,2-distéaroyl-sn-glycéro-3-phosphoéthanolamine-N-[amino(polyéthylène glycol)-2000 (DSPE-PEG(2000)NH2J.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | A PHARMACEUTICAL COMPOSITION COMPRISING 17-AAG AND STAUROSPORINE FOR USE IN THE PREVENTION OR TREATMENT OF CANCER AND DISEASES RESULTING FROM EXCESSIVE CELL PROLIFERATION AND A POLYMER- LIPID NANOPARTICLE CONTAINING THE COMPOSITION |
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