METHOD FOR PREDICTING EFFICACY OF BISPECIFIC FUSION POLYPEPTIDE IN SUBJECT
Provided is a method for predicting the efficacy of a bispecific fusion polypeptide in a subject, the method comprising comparing the level of a biomarker molecule in a sample taken from a subject with a cut-off value for the biomarker molecule. In the method: the subject is suffering from systemic...
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| creator | KANEKO, Yuko ONO, Yuuichi MOGAMI, Akira TAKEUCHI, Tsutomu |
| description | Provided is a method for predicting the efficacy of a bispecific fusion polypeptide in a subject, the method comprising comparing the level of a biomarker molecule in a sample taken from a subject with a cut-off value for the biomarker molecule. In the method: the subject is suffering from systemic sclerosis; the biomarker molecule is at least one biomarker molecule selected from the group consisting of IL-6, GDF15, LTBP2, CCL7, CHI3L1, EFEMP1, PLAUR, and SPON1; and the bispecific fusion polypeptide binds to IL-17a and includes a finomer sequence that forms a complex with an antibody that binds to IL-6R or with a partial sequence thereof that has IL-6R binding ability.
L'invention concerne une méthode permettant de prédire l'efficacité d'un polypeptide de fusion bispécifique chez un sujet, la méthode consistant à comparer le taux d'une molécule biomarqueur dans un échantillon prélevé sur un sujet avec une valeur seuil pour la molécule biomarqueur. Dans la méthode : le sujet souffre de sclérodermie généralisée ; la molécule biomarqueur est au moins une molécule biomarqueur choisie dans le groupe constitué par IL-6, GDF15, LTBP2, CCL7, CHI3L1, EFEMP1, PLAUR et SPON1 ; et le polypeptide de fusion bispécifique se lie à IL-17a et comprend une séquence finomère qui forme un complexe avec un anticorps qui se lie à IL-6R ou avec une séquence partielle de celui-ci qui a la capacité de se lier à IL-6R.
対象における二重特異性融合ポリペプチドの有効性を予測するための方法であって、対象から採取された試料におけるバイオマーカー分子のレベルを、前記バイオマーカー分子のカットオフ値と比較することを含み、対象が、全身性強皮症を患っており、バイオマーカー分子が、ＩＬ－６、ＧＤＦ１５、ＬＴＢＰ２、ＣＣＬ７、ＣＨＩ３Ｌ１、ＥＦＥＭＰ１、ＰＬＡＵＲおよびＳＰＯＮ１からなる群から選択される少なくとも１つのバイオマーカー分子であり、二重特異性融合ポリペプチドが、ＩＬ－１７ａに結合し、かつ、ＩＬ－６Ｒに結合する抗体またはＩＬ－６Ｒ結合能を有するその部分配列と複合体を形成しているフィノマー配列を含むものである、方法が提供される。 |
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L'invention concerne une méthode permettant de prédire l'efficacité d'un polypeptide de fusion bispécifique chez un sujet, la méthode consistant à comparer le taux d'une molécule biomarqueur dans un échantillon prélevé sur un sujet avec une valeur seuil pour la molécule biomarqueur. Dans la méthode : le sujet souffre de sclérodermie généralisée ; la molécule biomarqueur est au moins une molécule biomarqueur choisie dans le groupe constitué par IL-6, GDF15, LTBP2, CCL7, CHI3L1, EFEMP1, PLAUR et SPON1 ; et le polypeptide de fusion bispécifique se lie à IL-17a et comprend une séquence finomère qui forme un complexe avec un anticorps qui se lie à IL-6R ou avec une séquence partielle de celui-ci qui a la capacité de se lier à IL-6R.
対象における二重特異性融合ポリペプチドの有効性を予測するための方法であって、対象から採取された試料におけるバイオマーカー分子のレベルを、前記バイオマーカー分子のカットオフ値と比較することを含み、対象が、全身性強皮症を患っており、バイオマーカー分子が、ＩＬ－６、ＧＤＦ１５、ＬＴＢＰ２、ＣＣＬ７、ＣＨＩ３Ｌ１、ＥＦＥＭＰ１、ＰＬＡＵＲおよびＳＰＯＮ１からなる群から選択される少なくとも１つのバイオマーカー分子であり、二重特異性融合ポリペプチドが、ＩＬ－１７ａに結合し、かつ、ＩＬ－６Ｒに結合する抗体またはＩＬ－６Ｒ結合能を有するその部分配列と複合体を形成しているフィノマー配列を含むものである、方法が提供される。</description><language>eng ; fre ; jpn</language><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241107&DB=EPODOC&CC=WO&NR=2024228389A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241107&DB=EPODOC&CC=WO&NR=2024228389A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KANEKO, Yuko</creatorcontrib><creatorcontrib>ONO, Yuuichi</creatorcontrib><creatorcontrib>MOGAMI, Akira</creatorcontrib><creatorcontrib>TAKEUCHI, Tsutomu</creatorcontrib><title>METHOD FOR PREDICTING EFFICACY OF BISPECIFIC FUSION POLYPEPTIDE IN SUBJECT</title><description>Provided is a method for predicting the efficacy of a bispecific fusion polypeptide in a subject, the method comprising comparing the level of a biomarker molecule in a sample taken from a subject with a cut-off value for the biomarker molecule. In the method: the subject is suffering from systemic sclerosis; the biomarker molecule is at least one biomarker molecule selected from the group consisting of IL-6, GDF15, LTBP2, CCL7, CHI3L1, EFEMP1, PLAUR, and SPON1; and the bispecific fusion polypeptide binds to IL-17a and includes a finomer sequence that forms a complex with an antibody that binds to IL-6R or with a partial sequence thereof that has IL-6R binding ability.
L'invention concerne une méthode permettant de prédire l'efficacité d'un polypeptide de fusion bispécifique chez un sujet, la méthode consistant à comparer le taux d'une molécule biomarqueur dans un échantillon prélevé sur un sujet avec une valeur seuil pour la molécule biomarqueur. Dans la méthode : le sujet souffre de sclérodermie généralisée ; la molécule biomarqueur est au moins une molécule biomarqueur choisie dans le groupe constitué par IL-6, GDF15, LTBP2, CCL7, CHI3L1, EFEMP1, PLAUR et SPON1 ; et le polypeptide de fusion bispécifique se lie à IL-17a et comprend une séquence finomère qui forme un complexe avec un anticorps qui se lie à IL-6R ou avec une séquence partielle de celui-ci qui a la capacité de se lier à IL-6R.
対象における二重特異性融合ポリペプチドの有効性を予測するための方法であって、対象から採取された試料におけるバイオマーカー分子のレベルを、前記バイオマーカー分子のカットオフ値と比較することを含み、対象が、全身性強皮症を患っており、バイオマーカー分子が、ＩＬ－６、ＧＤＦ１５、ＬＴＢＰ２、ＣＣＬ７、ＣＨＩ３Ｌ１、ＥＦＥＭＰ１、ＰＬＡＵＲおよびＳＰＯＮ１からなる群から選択される少なくとも１つのバイオマーカー分子であり、二重特異性融合ポリペプチドが、ＩＬ－１７ａに結合し、かつ、ＩＬ－６Ｒに結合する抗体またはＩＬ－６Ｒ結合能を有するその部分配列と複合体を形成しているフィノマー配列を含むものである、方法が提供される。</description><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPDydQ3x8HdRcPMPUggIcnXxdA7x9HNXcHVz83R2dI5U8HdTcPIMDnB19gQKKLiFBnv6-ykE-PtEBrgGhHi6uCp4-ikEhzp5uTqH8DCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-HB_IwMjEyMjC2MLS0dDY-JUAQAH5i5M</recordid><startdate>20241107</startdate><enddate>20241107</enddate><creator>KANEKO, Yuko</creator><creator>ONO, Yuuichi</creator><creator>MOGAMI, Akira</creator><creator>TAKEUCHI, Tsutomu</creator><scope>EVB</scope></search><sort><creationdate>20241107</creationdate><title>METHOD FOR PREDICTING EFFICACY OF BISPECIFIC FUSION POLYPEPTIDE IN SUBJECT</title><author>KANEKO, Yuko ; ONO, Yuuichi ; MOGAMI, Akira ; TAKEUCHI, Tsutomu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024228389A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; jpn</language><creationdate>2024</creationdate><topic>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KANEKO, Yuko</creatorcontrib><creatorcontrib>ONO, Yuuichi</creatorcontrib><creatorcontrib>MOGAMI, Akira</creatorcontrib><creatorcontrib>TAKEUCHI, Tsutomu</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KANEKO, Yuko</au><au>ONO, Yuuichi</au><au>MOGAMI, Akira</au><au>TAKEUCHI, Tsutomu</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR PREDICTING EFFICACY OF BISPECIFIC FUSION POLYPEPTIDE IN SUBJECT</title><date>2024-11-07</date><risdate>2024</risdate><abstract>Provided is a method for predicting the efficacy of a bispecific fusion polypeptide in a subject, the method comprising comparing the level of a biomarker molecule in a sample taken from a subject with a cut-off value for the biomarker molecule. In the method: the subject is suffering from systemic sclerosis; the biomarker molecule is at least one biomarker molecule selected from the group consisting of IL-6, GDF15, LTBP2, CCL7, CHI3L1, EFEMP1, PLAUR, and SPON1; and the bispecific fusion polypeptide binds to IL-17a and includes a finomer sequence that forms a complex with an antibody that binds to IL-6R or with a partial sequence thereof that has IL-6R binding ability.
L'invention concerne une méthode permettant de prédire l'efficacité d'un polypeptide de fusion bispécifique chez un sujet, la méthode consistant à comparer le taux d'une molécule biomarqueur dans un échantillon prélevé sur un sujet avec une valeur seuil pour la molécule biomarqueur. Dans la méthode : le sujet souffre de sclérodermie généralisée ; la molécule biomarqueur est au moins une molécule biomarqueur choisie dans le groupe constitué par IL-6, GDF15, LTBP2, CCL7, CHI3L1, EFEMP1, PLAUR et SPON1 ; et le polypeptide de fusion bispécifique se lie à IL-17a et comprend une séquence finomère qui forme un complexe avec un anticorps qui se lie à IL-6R ou avec une séquence partielle de celui-ci qui a la capacité de se lier à IL-6R.
対象における二重特異性融合ポリペプチドの有効性を予測するための方法であって、対象から採取された試料におけるバイオマーカー分子のレベルを、前記バイオマーカー分子のカットオフ値と比較することを含み、対象が、全身性強皮症を患っており、バイオマーカー分子が、ＩＬ－６、ＧＤＦ１５、ＬＴＢＰ２、ＣＣＬ７、ＣＨＩ３Ｌ１、ＥＦＥＭＰ１、ＰＬＡＵＲおよびＳＰＯＮ１からなる群から選択される少なくとも１つのバイオマーカー分子であり、二重特異性融合ポリペプチドが、ＩＬ－１７ａに結合し、かつ、ＩＬ－６Ｒに結合する抗体またはＩＬ－６Ｒ結合能を有するその部分配列と複合体を形成しているフィノマー配列を含むものである、方法が提供される。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | METHOD FOR PREDICTING EFFICACY OF BISPECIFIC FUSION POLYPEPTIDE IN SUBJECT |
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