INDUSTRIALIZATION PREPARATION METHOD FOR PACLITAXEL SUBMICRON EMULSION INJECTION
An industrialization preparation method for a paclitaxel submicron emulsion injection. The method comprises the following steps carried out in a submicron emulsion injection preparation system: S1, formulating an aqueous phase in an aqueous phase tank; S2, formulating an oil phase in an oil phase ta...
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| creator | JIN, Yiqun LIU, Zhihua SUN, Dejun SUO, Shiyue GAO, Huiyu LIU, Meng WANG, Yanan QIN, Caiyun WANG, Huibin WANG, Lu LIU, Yang SHEN, Qiqi YANG, Hongzhen WANG, Yujie |
| description | An industrialization preparation method for a paclitaxel submicron emulsion injection. The method comprises the following steps carried out in a submicron emulsion injection preparation system: S1, formulating an aqueous phase in an aqueous phase tank; S2, formulating an oil phase in an oil phase tank; and S3, starting the submicron emulsion injection preparation system, and executing emulsification, homogenization and feed liquid transfer operations to obtain a final emulsion; and S4, canning the final emulsion, and sterilizing same to obtain a paclitaxel submicron emulsion injection. The industrialization preparation method can achieve large-scale submicron emulsion production and automatic cleaning and online sterilization of the whole system, and can achieve whole-process accurate temperature control, nitrogen charging and oxygen removal, closed bacteria isolation and whole-process automatic operation. The defects of closed operation and whole-process nitrogen charging being not capable of being carried o |
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The method comprises the following steps carried out in a submicron emulsion injection preparation system: S1, formulating an aqueous phase in an aqueous phase tank; S2, formulating an oil phase in an oil phase tank; and S3, starting the submicron emulsion injection preparation system, and executing emulsification, homogenization and feed liquid transfer operations to obtain a final emulsion; and S4, canning the final emulsion, and sterilizing same to obtain a paclitaxel submicron emulsion injection. The industrialization preparation method can achieve large-scale submicron emulsion production and automatic cleaning and online sterilization of the whole system, and can achieve whole-process accurate temperature control, nitrogen charging and oxygen removal, closed bacteria isolation and whole-process automatic operation. 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The method comprises the following steps carried out in a submicron emulsion injection preparation system: S1, formulating an aqueous phase in an aqueous phase tank; S2, formulating an oil phase in an oil phase tank; and S3, starting the submicron emulsion injection preparation system, and executing emulsification, homogenization and feed liquid transfer operations to obtain a final emulsion; and S4, canning the final emulsion, and sterilizing same to obtain a paclitaxel submicron emulsion injection. The industrialization preparation method can achieve large-scale submicron emulsion production and automatic cleaning and online sterilization of the whole system, and can achieve whole-process accurate temperature control, nitrogen charging and oxygen removal, closed bacteria isolation and whole-process automatic operation. The defects of closed operation and whole-process nitrogen charging being not capable of being carried o</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR RELEVANT APPARATUS TRANSPORTING |
| title | INDUSTRIALIZATION PREPARATION METHOD FOR PACLITAXEL SUBMICRON EMULSION INJECTION |
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