INDUSTRIALIZATION PREPARATION METHOD FOR PACLITAXEL SUBMICRON EMULSION INJECTION

An industrialization preparation method for a paclitaxel submicron emulsion injection. The method comprises the following steps carried out in a submicron emulsion injection preparation system: S1, formulating an aqueous phase in an aqueous phase tank; S2, formulating an oil phase in an oil phase ta...

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Hauptverfasser: JIN, Yiqun, LIU, Zhihua, SUN, Dejun, SUO, Shiyue, GAO, Huiyu, LIU, Meng, WANG, Yanan, QIN, Caiyun, WANG, Huibin, WANG, Lu, LIU, Yang, SHEN, Qiqi, YANG, Hongzhen, WANG, Yujie
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creator JIN, Yiqun
LIU, Zhihua
SUN, Dejun
SUO, Shiyue
GAO, Huiyu
LIU, Meng
WANG, Yanan
QIN, Caiyun
WANG, Huibin
WANG, Lu
LIU, Yang
SHEN, Qiqi
YANG, Hongzhen
WANG, Yujie
description An industrialization preparation method for a paclitaxel submicron emulsion injection. The method comprises the following steps carried out in a submicron emulsion injection preparation system: S1, formulating an aqueous phase in an aqueous phase tank; S2, formulating an oil phase in an oil phase tank; and S3, starting the submicron emulsion injection preparation system, and executing emulsification, homogenization and feed liquid transfer operations to obtain a final emulsion; and S4, canning the final emulsion, and sterilizing same to obtain a paclitaxel submicron emulsion injection. The industrialization preparation method can achieve large-scale submicron emulsion production and automatic cleaning and online sterilization of the whole system, and can achieve whole-process accurate temperature control, nitrogen charging and oxygen removal, closed bacteria isolation and whole-process automatic operation. The defects of closed operation and whole-process nitrogen charging being not capable of being carried o
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subjects CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR RELEVANT APPARATUS
TRANSPORTING
title INDUSTRIALIZATION PREPARATION METHOD FOR PACLITAXEL SUBMICRON EMULSION INJECTION
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