BIARYL DERIVATIVES AND RELATED USES
The present disclosure relates to compounds of Formula (I), and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating DNA polymerase Q activity and may be used in...
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| creator | YAN, Xin REUTERSHAN, Michael H WANG, Haoxuan MCGOWAN, Meredeth A SCHENKEL, Laurie B BUTLER, John R GAO, Cen BAI, Yonghong GUZI, Timothy J |
| description | The present disclosure relates to compounds of Formula (I), and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating DNA polymerase Q activity and may be used in the treatment of disorders in which DNA polymerase Q activity is implicated, such as cancer.
La présente invention concerne des composés de formule (I), et leurs promédicaments, des sels pharmaceutiquement acceptables, des compositions pharmaceutiques, des procédés d'utilisation et des procédés pour leur préparation. Les composés de l'invention sont utiles pour moduler l'activité de l'ADN polymérase Q et peuvent être utilisés dans le traitement de troubles dans lesquels l'activité de l'ADN polymérase Q est impliquée, notamment le cancer. |
| format | Patent |
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La présente invention concerne des composés de formule (I), et leurs promédicaments, des sels pharmaceutiquement acceptables, des compositions pharmaceutiques, des procédés d'utilisation et des procédés pour leur préparation. Les composés de l'invention sont utiles pour moduler l'activité de l'ADN polymérase Q et peuvent être utilisés dans le traitement de troubles dans lesquels l'activité de l'ADN polymérase Q est impliquée, notamment le cancer.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241010&DB=EPODOC&CC=WO&NR=2024211834A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241010&DB=EPODOC&CC=WO&NR=2024211834A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YAN, Xin</creatorcontrib><creatorcontrib>REUTERSHAN, Michael H</creatorcontrib><creatorcontrib>WANG, Haoxuan</creatorcontrib><creatorcontrib>MCGOWAN, Meredeth A</creatorcontrib><creatorcontrib>SCHENKEL, Laurie B</creatorcontrib><creatorcontrib>BUTLER, John R</creatorcontrib><creatorcontrib>GAO, Cen</creatorcontrib><creatorcontrib>BAI, Yonghong</creatorcontrib><creatorcontrib>GUZI, Timothy J</creatorcontrib><title>BIARYL DERIVATIVES AND RELATED USES</title><description>The present disclosure relates to compounds of Formula (I), and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating DNA polymerase Q activity and may be used in the treatment of disorders in which DNA polymerase Q activity is implicated, such as cancer.
La présente invention concerne des composés de formule (I), et leurs promédicaments, des sels pharmaceutiquement acceptables, des compositions pharmaceutiques, des procédés d'utilisation et des procédés pour leur préparation. Les composés de l'invention sont utiles pour moduler l'activité de l'ADN polymérase Q et peuvent être utilisés dans le traitement de troubles dans lesquels l'activité de l'ADN polymérase Q est impliquée, notamment le cancer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB28nQMivRRcHEN8gxzDPEMcw1WcPRzUQhy9XEMcXVRCA12DeZhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGRiZGhoYWxiaOhsbEqQIA30YjjQ</recordid><startdate>20241010</startdate><enddate>20241010</enddate><creator>YAN, Xin</creator><creator>REUTERSHAN, Michael H</creator><creator>WANG, Haoxuan</creator><creator>MCGOWAN, Meredeth A</creator><creator>SCHENKEL, Laurie B</creator><creator>BUTLER, John R</creator><creator>GAO, Cen</creator><creator>BAI, Yonghong</creator><creator>GUZI, Timothy J</creator><scope>EVB</scope></search><sort><creationdate>20241010</creationdate><title>BIARYL DERIVATIVES AND RELATED USES</title><author>YAN, Xin ; REUTERSHAN, Michael H ; WANG, Haoxuan ; MCGOWAN, Meredeth A ; SCHENKEL, Laurie B ; BUTLER, John R ; GAO, Cen ; BAI, Yonghong ; GUZI, Timothy J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024211834A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>YAN, Xin</creatorcontrib><creatorcontrib>REUTERSHAN, Michael H</creatorcontrib><creatorcontrib>WANG, Haoxuan</creatorcontrib><creatorcontrib>MCGOWAN, Meredeth A</creatorcontrib><creatorcontrib>SCHENKEL, Laurie B</creatorcontrib><creatorcontrib>BUTLER, John R</creatorcontrib><creatorcontrib>GAO, Cen</creatorcontrib><creatorcontrib>BAI, Yonghong</creatorcontrib><creatorcontrib>GUZI, Timothy J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YAN, Xin</au><au>REUTERSHAN, Michael H</au><au>WANG, Haoxuan</au><au>MCGOWAN, Meredeth A</au><au>SCHENKEL, Laurie B</au><au>BUTLER, John R</au><au>GAO, Cen</au><au>BAI, Yonghong</au><au>GUZI, Timothy J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BIARYL DERIVATIVES AND RELATED USES</title><date>2024-10-10</date><risdate>2024</risdate><abstract>The present disclosure relates to compounds of Formula (I), and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating DNA polymerase Q activity and may be used in the treatment of disorders in which DNA polymerase Q activity is implicated, such as cancer.
La présente invention concerne des composés de formule (I), et leurs promédicaments, des sels pharmaceutiquement acceptables, des compositions pharmaceutiques, des procédés d'utilisation et des procédés pour leur préparation. Les composés de l'invention sont utiles pour moduler l'activité de l'ADN polymérase Q et peuvent être utilisés dans le traitement de troubles dans lesquels l'activité de l'ADN polymérase Q est impliquée, notamment le cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BIARYL DERIVATIVES AND RELATED USES |
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