PHARMACEUTICAL COMPOSITION EXHIBITING TUBULIN INHIBITORY ACTIVITY

The present invention relates to a pharmaceutical composition comprising, as an active ingredient, a compound exhibiting tubulin inhibitory activity or a pharmaceutically acceptable salt thereof. The pharmaceutical composition of the present invention inhibits tubulin polymerization, and thus can be...

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Bibliographische Detailangaben
Hauptverfasser: JANG, Gyu-beom, LEE, Junho, AHN, Chi-Hyun, YANG, Youngeun
Format: Patent
Sprache:eng ; fre ; kor
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Zusammenfassung:The present invention relates to a pharmaceutical composition comprising, as an active ingredient, a compound exhibiting tubulin inhibitory activity or a pharmaceutically acceptable salt thereof. The pharmaceutical composition of the present invention inhibits tubulin polymerization, and thus can be very effectively used, in particular, for preventing or treating inflammatory diseases, acute respiratory distress syndrome, actinic keratosis or angiogenesis-associated diseases. La présente invention concerne une composition pharmaceutique comprenant comme principe actif un composé présentant une activité inhibitrice de la tubuline ou un sel pharmaceutiquement acceptable de celui-ci. La composition pharmaceutique de la présente invention inhibe la polymérisation de la tubuline et peut ainsi être utilisée très efficacement, en particulier pour prévenir ou traiter des maladies inflammatoires, le syndrome de détresse respiratoire aiguë, la kératose actinique ou des maladies associées à l'angiogenèse. 본 발명은 튜블린 저해 활성을 갖는 화합물 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 약학적 조성물에 관한 것이다. 본 발명의 약학적 조성물은 튜블린 폴리머화를 억제하므로, 특히 염증성 질환, 급성 호흡곤란 증후군, 광선각화증 또는 신혈관 형성 관련 질환의 예방 또는 치료 용도로 매우 유용하게 사용될 수 있다.