DARATUMUMAB DRUG CONJUGATES AND PREPARATION THEREOF

The invention provides antibody-linker-drug conjugates wherein antibody is daratumumab and drug is auristatin analogues or a pharmaceutically acceptable salt thereof. The invention also provides a process of preparing antibody-linker-conjugates of the present invention. L'invention concerne des...

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Bibliographische Detailangaben
Hauptverfasser:	SONI, Swagat, SINGH, Avanish, KALITA, Pankaj, BANDYOPADHYAY, Sanjay, MENDIRATTA, Sanjeev Kumar
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides antibody-linker-drug conjugates wherein antibody is daratumumab and drug is auristatin analogues or a pharmaceutically acceptable salt thereof. The invention also provides a process of preparing antibody-linker-conjugates of the present invention. L'invention concerne des conjugués anticorps-lieur-médicament dans lesquels l'anticorps est le daratumumab et le médicament est des analogues d'auristatine ou un sel pharmaceutiquement acceptable correspondant. L'invention concerne également un procédé de préparation de conjugués anticorps-lieur-médicament de la présente invention.