NON-HUMAN ANIMALS COMPRISING A GENETICALLY MODIFIED ENDOGENOUS IGHA LOCUS AND METHODS OF MAKING THE SAME
The present disclosure provides non-human animals displaying a clinical sign of a disease associated with IgA deposition (e.g., IgA nephropathy) and comprising in its genome a genetically modified endogenous Igha locus comprising a heterologous gene that encodes a human IgA (e.g., IgA1) heavy chain...
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| creator | LV, Jicheng ZHANG, Hong WANG, Manliu LI, Jingyi TIAN, Jin ZAN, Jincan DONG, Yaping LI, Run |
| description | The present disclosure provides non-human animals displaying a clinical sign of a disease associated with IgA deposition (e.g., IgA nephropathy) and comprising in its genome a genetically modified endogenous Igha locus comprising a heterologous gene that encodes a human IgA (e.g., IgA1) heavy chain constant region or a fragment thereof. The present disclosure also provides methods of making the non-human animals or uses of the non-human animals.
La présente invention concerne des animaux non humains présentant un signe clinique d'une maladie associée à un dépôt d'IgA (par exemple, la néphropathie à IgA) et comprenant dans leur génome un locus Igha endogène génétiquement modifié comprenant un gène hétérologue qui code pour une région constante de chaîne lourde d'IgA humaine (par exemple, IgA1) ou pour un fragment de celle-ci. La présente invention concerne également des procédés de production des animaux non humains ou des utilisations des animaux non humains. |
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La présente invention concerne des animaux non humains présentant un signe clinique d'une maladie associée à un dépôt d'IgA (par exemple, la néphropathie à IgA) et comprenant dans leur génome un locus Igha endogène génétiquement modifié comprenant un gène hétérologue qui code pour une région constante de chaîne lourde d'IgA humaine (par exemple, IgA1) ou pour un fragment de celle-ci. La présente invention concerne également des procédés de production des animaux non humains ou des utilisations des animaux non humains.</description><language>eng ; fre</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BEER ; BIOCHEMISTRY ; CARE OF BIRDS, FISHES, INSECTS ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NEW BREEDS OF ANIMALS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR ; SPIRITS ; TRAPPING ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240926&DB=EPODOC&CC=WO&NR=2024192978A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240926&DB=EPODOC&CC=WO&NR=2024192978A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LV, Jicheng</creatorcontrib><creatorcontrib>ZHANG, Hong</creatorcontrib><creatorcontrib>WANG, Manliu</creatorcontrib><creatorcontrib>LI, Jingyi</creatorcontrib><creatorcontrib>TIAN, Jin</creatorcontrib><creatorcontrib>ZAN, Jincan</creatorcontrib><creatorcontrib>DONG, Yaping</creatorcontrib><creatorcontrib>LI, Run</creatorcontrib><title>NON-HUMAN ANIMALS COMPRISING A GENETICALLY MODIFIED ENDOGENOUS IGHA LOCUS AND METHODS OF MAKING THE SAME</title><description>The present disclosure provides non-human animals displaying a clinical sign of a disease associated with IgA deposition (e.g., IgA nephropathy) and comprising in its genome a genetically modified endogenous Igha locus comprising a heterologous gene that encodes a human IgA (e.g., IgA1) heavy chain constant region or a fragment thereof. The present disclosure also provides methods of making the non-human animals or uses of the non-human animals.
La présente invention concerne des animaux non humains présentant un signe clinique d'une maladie associée à un dépôt d'IgA (par exemple, la néphropathie à IgA) et comprenant dans leur génome un locus Igha endogène génétiquement modifié comprenant un gène hétérologue qui code pour une région constante de chaîne lourde d'IgA humaine (par exemple, IgA1) ou pour un fragment de celle-ci. La présente invention concerne également des procédés de production des animaux non humains ou des utilisations des animaux non humains.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CARE OF BIRDS, FISHES, INSECTS</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NEW BREEDS OF ANIMALS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</subject><subject>SPIRITS</subject><subject>TRAPPING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEEKwjAQRbtxIeodBlwXbBW0yyGZNsFkRkyKuCpFIi5EC_X-qOABXP0H7_Gn2Y2Fc9N6ZEC2Hl0AJf5wtMFyAwgNMUWr0LkzeNG2tqSBWMtHSBvANgbBifogsgZP0YgOIDV43H8voiEI6GmeTa79fUyL386yZU1RmTwNzy6NQ39Jj_TqTlKuyk1RldV2h8X6v-oNxls2Kw</recordid><startdate>20240926</startdate><enddate>20240926</enddate><creator>LV, Jicheng</creator><creator>ZHANG, Hong</creator><creator>WANG, Manliu</creator><creator>LI, Jingyi</creator><creator>TIAN, Jin</creator><creator>ZAN, Jincan</creator><creator>DONG, Yaping</creator><creator>LI, Run</creator><scope>EVB</scope></search><sort><creationdate>20240926</creationdate><title>NON-HUMAN ANIMALS COMPRISING A GENETICALLY MODIFIED ENDOGENOUS IGHA LOCUS AND METHODS OF MAKING THE SAME</title><author>LV, Jicheng ; ZHANG, Hong ; WANG, Manliu ; LI, Jingyi ; TIAN, Jin ; ZAN, Jincan ; DONG, Yaping ; LI, Run</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024192978A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CARE OF BIRDS, FISHES, INSECTS</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NEW BREEDS OF ANIMALS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR</topic><topic>SPIRITS</topic><topic>TRAPPING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LV, Jicheng</creatorcontrib><creatorcontrib>ZHANG, Hong</creatorcontrib><creatorcontrib>WANG, Manliu</creatorcontrib><creatorcontrib>LI, Jingyi</creatorcontrib><creatorcontrib>TIAN, Jin</creatorcontrib><creatorcontrib>ZAN, Jincan</creatorcontrib><creatorcontrib>DONG, Yaping</creatorcontrib><creatorcontrib>LI, Run</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LV, Jicheng</au><au>ZHANG, Hong</au><au>WANG, Manliu</au><au>LI, Jingyi</au><au>TIAN, Jin</au><au>ZAN, Jincan</au><au>DONG, Yaping</au><au>LI, Run</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NON-HUMAN ANIMALS COMPRISING A GENETICALLY MODIFIED ENDOGENOUS IGHA LOCUS AND METHODS OF MAKING THE SAME</title><date>2024-09-26</date><risdate>2024</risdate><abstract>The present disclosure provides non-human animals displaying a clinical sign of a disease associated with IgA deposition (e.g., IgA nephropathy) and comprising in its genome a genetically modified endogenous Igha locus comprising a heterologous gene that encodes a human IgA (e.g., IgA1) heavy chain constant region or a fragment thereof. The present disclosure also provides methods of making the non-human animals or uses of the non-human animals.
La présente invention concerne des animaux non humains présentant un signe clinique d'une maladie associée à un dépôt d'IgA (par exemple, la néphropathie à IgA) et comprenant dans leur génome un locus Igha endogène génétiquement modifié comprenant un gène hétérologue qui code pour une région constante de chaîne lourde d'IgA humaine (par exemple, IgA1) ou pour un fragment de celle-ci. La présente invention concerne également des procédés de production des animaux non humains ou des utilisations des animaux non humains.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TRAPPING VINEGAR WINE |
| title | NON-HUMAN ANIMALS COMPRISING A GENETICALLY MODIFIED ENDOGENOUS IGHA LOCUS AND METHODS OF MAKING THE SAME |
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