SERPINA-MODULATING COMPOSITIONS AND METHODS

The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Improved gRNA scaffolds compatible with St1Cas9 are described. L'invention con...

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Bibliographische Detailangaben
Hauptverfasser:	DONG, Xiaolong, COTTA-RAMUSINO, Cecilia Giovanna Silvia, JANCSO, Zsanett, MENDOZA, Alan Fabian, APPONI, Luciano Henrique, MIR, Aamir, BOTHMER, Anne Helen
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Improved gRNA scaffolds compatible with St1Cas9 are described. L'invention concerne, par exemple, des compositions, des systèmes et des procédés de ciblage, d'édition, de modification ou de manipulation d'un génome de cellule hôte à un ou plusieurs emplacements dans une séquence d'ADN dans une cellule, un tissu ou un sujet. L'invention concerne également des échafaudages d'ARNg améliorés compatibles avec St1Cas9.