TARGETING CELLS IN STRESSED GROWING CONDITIONS
The present invention provides method of killing first cells (for example pathogenic cells) which are slow-growing under stress conditions (for example, stationary phase cells, stressed cells, persister cells, biofilm cells and dormant cells) by providing a vector encoding a toxic agent or component...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | KRAUSE HAABER, Jakob ERIKSEN, Melissa Kviesgaard SEMSEY, Szabolcs |
| description | The present invention provides method of killing first cells (for example pathogenic cells) which are slow-growing under stress conditions (for example, stationary phase cells, stressed cells, persister cells, biofilm cells and dormant cells) by providing a vector encoding a toxic agent or component thereof under the control of a stress-phase active (SPA) promoter. The invention also provides methods of expressing proteins of interest (POIs) in such slow-growing cells under stress conditions, which POIs may be therapeutic molecules and reporter genes for example, by providing a vector encoding a POI under the control of a SPA promoter. There are provided methods of treatment using such vectors.
La présente invention concerne un procédé de destruction de premières cellules (par exemple des cellules pathogènes) qui se développent lentement dans des conditions de stress (par exemple, des cellules en phase stationnaire, des cellules stressées, des cellules de persister, des cellules de biofilm et des cellules dormantes) en fournissant un vecteur codant pour un agent toxique ou un composant de celui-ci sous le contrôle d'un promoteur actif en phase de stress (SPA). L'invention concerne également des procédés d'expression de protéines d'intérêt (POI) dans de telles cellules à croissance lente dans des conditions de stress, lesquelles POI peuvent être des molécules thérapeutiques et des gènes rapporteurs par exemple, en fournissant un vecteur codant pour une POI sous le contrôle d'un promoteur SPA. L'invention concerne également des procédés de traitement utilisant de tels vecteurs. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2024184403A2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2024184403A2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2024184403A23</originalsourceid><addsrcrecordid>eNrjZNALcQxydw3x9HNXcHb18QlW8PRTCA4Jcg0OdnVRcA_yDwfL-Pu5eIZ4-vsF8zCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-HB_IwMjE0MLExMDY0cjY-JUAQCMECbS</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>TARGETING CELLS IN STRESSED GROWING CONDITIONS</title><source>esp@cenet</source><creator>KRAUSE HAABER, Jakob ; ERIKSEN, Melissa Kviesgaard ; SEMSEY, Szabolcs</creator><creatorcontrib>KRAUSE HAABER, Jakob ; ERIKSEN, Melissa Kviesgaard ; SEMSEY, Szabolcs</creatorcontrib><description>The present invention provides method of killing first cells (for example pathogenic cells) which are slow-growing under stress conditions (for example, stationary phase cells, stressed cells, persister cells, biofilm cells and dormant cells) by providing a vector encoding a toxic agent or component thereof under the control of a stress-phase active (SPA) promoter. The invention also provides methods of expressing proteins of interest (POIs) in such slow-growing cells under stress conditions, which POIs may be therapeutic molecules and reporter genes for example, by providing a vector encoding a POI under the control of a SPA promoter. There are provided methods of treatment using such vectors.
La présente invention concerne un procédé de destruction de premières cellules (par exemple des cellules pathogènes) qui se développent lentement dans des conditions de stress (par exemple, des cellules en phase stationnaire, des cellules stressées, des cellules de persister, des cellules de biofilm et des cellules dormantes) en fournissant un vecteur codant pour un agent toxique ou un composant de celui-ci sous le contrôle d'un promoteur actif en phase de stress (SPA). L'invention concerne également des procédés d'expression de protéines d'intérêt (POI) dans de telles cellules à croissance lente dans des conditions de stress, lesquelles POI peuvent être des molécules thérapeutiques et des gènes rapporteurs par exemple, en fournissant un vecteur codant pour une POI sous le contrôle d'un promoteur SPA. L'invention concerne également des procédés de traitement utilisant de tels vecteurs.</description><language>eng ; fre</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BEER ; BIOCHEMISTRY ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PEST REPELLANTS OR ATTRACTANTS ; PLANT GROWTH REGULATORS ; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TRAPPING ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240912&DB=EPODOC&CC=WO&NR=2024184403A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240912&DB=EPODOC&CC=WO&NR=2024184403A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KRAUSE HAABER, Jakob</creatorcontrib><creatorcontrib>ERIKSEN, Melissa Kviesgaard</creatorcontrib><creatorcontrib>SEMSEY, Szabolcs</creatorcontrib><title>TARGETING CELLS IN STRESSED GROWING CONDITIONS</title><description>The present invention provides method of killing first cells (for example pathogenic cells) which are slow-growing under stress conditions (for example, stationary phase cells, stressed cells, persister cells, biofilm cells and dormant cells) by providing a vector encoding a toxic agent or component thereof under the control of a stress-phase active (SPA) promoter. The invention also provides methods of expressing proteins of interest (POIs) in such slow-growing cells under stress conditions, which POIs may be therapeutic molecules and reporter genes for example, by providing a vector encoding a POI under the control of a SPA promoter. There are provided methods of treatment using such vectors.
La présente invention concerne un procédé de destruction de premières cellules (par exemple des cellules pathogènes) qui se développent lentement dans des conditions de stress (par exemple, des cellules en phase stationnaire, des cellules stressées, des cellules de persister, des cellules de biofilm et des cellules dormantes) en fournissant un vecteur codant pour un agent toxique ou un composant de celui-ci sous le contrôle d'un promoteur actif en phase de stress (SPA). L'invention concerne également des procédés d'expression de protéines d'intérêt (POI) dans de telles cellules à croissance lente dans des conditions de stress, lesquelles POI peuvent être des molécules thérapeutiques et des gènes rapporteurs par exemple, en fournissant un vecteur codant pour une POI sous le contrôle d'un promoteur SPA. L'invention concerne également des procédés de traitement utilisant de tels vecteurs.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TRAPPING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNALcQxydw3x9HNXcHb18QlW8PRTCA4Jcg0OdnVRcA_yDwfL-Pu5eIZ4-vsF8zCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-HB_IwMjE0MLExMDY0cjY-JUAQCMECbS</recordid><startdate>20240912</startdate><enddate>20240912</enddate><creator>KRAUSE HAABER, Jakob</creator><creator>ERIKSEN, Melissa Kviesgaard</creator><creator>SEMSEY, Szabolcs</creator><scope>EVB</scope></search><sort><creationdate>20240912</creationdate><title>TARGETING CELLS IN STRESSED GROWING CONDITIONS</title><author>KRAUSE HAABER, Jakob ; ERIKSEN, Melissa Kviesgaard ; SEMSEY, Szabolcs</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024184403A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PEST REPELLANTS OR ATTRACTANTS</topic><topic>PLANT GROWTH REGULATORS</topic><topic>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TRAPPING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KRAUSE HAABER, Jakob</creatorcontrib><creatorcontrib>ERIKSEN, Melissa Kviesgaard</creatorcontrib><creatorcontrib>SEMSEY, Szabolcs</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KRAUSE HAABER, Jakob</au><au>ERIKSEN, Melissa Kviesgaard</au><au>SEMSEY, Szabolcs</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TARGETING CELLS IN STRESSED GROWING CONDITIONS</title><date>2024-09-12</date><risdate>2024</risdate><abstract>The present invention provides method of killing first cells (for example pathogenic cells) which are slow-growing under stress conditions (for example, stationary phase cells, stressed cells, persister cells, biofilm cells and dormant cells) by providing a vector encoding a toxic agent or component thereof under the control of a stress-phase active (SPA) promoter. The invention also provides methods of expressing proteins of interest (POIs) in such slow-growing cells under stress conditions, which POIs may be therapeutic molecules and reporter genes for example, by providing a vector encoding a POI under the control of a SPA promoter. There are provided methods of treatment using such vectors.
La présente invention concerne un procédé de destruction de premières cellules (par exemple des cellules pathogènes) qui se développent lentement dans des conditions de stress (par exemple, des cellules en phase stationnaire, des cellules stressées, des cellules de persister, des cellules de biofilm et des cellules dormantes) en fournissant un vecteur codant pour un agent toxique ou un composant de celui-ci sous le contrôle d'un promoteur actif en phase de stress (SPA). L'invention concerne également des procédés d'expression de protéines d'intérêt (POI) dans de telles cellules à croissance lente dans des conditions de stress, lesquelles POI peuvent être des molécules thérapeutiques et des gènes rapporteurs par exemple, en fournissant un vecteur codant pour une POI sous le contrôle d'un promoteur SPA. L'invention concerne également des procédés de traitement utilisant de tels vecteurs.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2024184403A2 |
| source | esp@cenet |
| subjects | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRAPPING VINEGAR WINE |
| title | TARGETING CELLS IN STRESSED GROWING CONDITIONS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T03%3A12%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KRAUSE%20HAABER,%20Jakob&rft.date=2024-09-12&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2024184403A2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |