NEW MULTI-FUNCTIONAL OLIGOPEPTIDES

There is provided a compound of formula (I), A-Q-B (I) wherein Q represents a structural fragment of formula (II), wherein: the squiggly lines and m have meanings given in the description, and wherein A and B have meanings given in the description, but may represent a peptide component of the amino...

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Hauptverfasser: SONG, Maoqian, GU, Ming, KANG, Ruijuan, HAEGGSTRÖM, Jesper
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creator SONG, Maoqian
GU, Ming
KANG, Ruijuan
HAEGGSTRÖM, Jesper
description There is provided a compound of formula (I), A-Q-B (I) wherein Q represents a structural fragment of formula (II), wherein: the squiggly lines and m have meanings given in the description, and wherein A and B have meanings given in the description, but may represent a peptide component of the amino acid sequence: [(W)m-Lys-X1-T- (U)m- (X2)m- (Y)m]n- (W)m-Lys-X1-T- (U)m- (X2)m- (Y)m (SEQ ID No: 1); wherein n, m, T, W, X1, U, X2 and Y have meanings given in the description, which compounds are useful in medicine, including as pharmaceutical excipients, adhesives and film-forming materials and/or are useful in the treatment of conditions characterised by inflammation, including wounds, burns, and disorders of the mucosa, such as anorectal diseases, inflammatory bowel diseases, gynaecological diseases and dental diseases. L'invention concerne un composé de formule (I), A-Q-B (I) dans laquelle Q représente un fragment structural de formule (II) dans laquelle : les lignes ondulées et m ont les significations mentionnées dans la description, et dans laquelle A et B ont les significations mentionnées dans la description, mais peuvent représenter un composant peptidique de la séquence d'acides aminés : [(W)m-Lys-X1-T- (U)m- (X2)m- (Y)m]n- (W)m-Lys-X1-T- (U)m- (X2)m- (Y)m (SEQ ID No : 1) ; n, m, T, W, X1, U, X2 et Y ayant les significations mentionnées dans la description, lesdits composés étant utiles en médecine, y compris en tant qu'excipients pharmaceutiques, adhésifs et matériaux filmogènes et/ou étant utiles dans le traitement d'affections caractérisées par une inflammation, notamment des plaies, des brûlures et des troubles de la muqueuse tels que des maladies anorectales, des maladies intestinales inflammatoires, des maladies gynécologiques et des maladies dentaires.
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L'invention concerne un composé de formule (I), A-Q-B (I) dans laquelle Q représente un fragment structural de formule (II) dans laquelle : les lignes ondulées et m ont les significations mentionnées dans la description, et dans laquelle A et B ont les significations mentionnées dans la description, mais peuvent représenter un composant peptidique de la séquence d'acides aminés : [(W)m-Lys-X1-T- (U)m- (X2)m- (Y)m]n- (W)m-Lys-X1-T- (U)m- (X2)m- (Y)m (SEQ ID No : 1) ; n, m, T, W, X1, U, X2 et Y ayant les significations mentionnées dans la description, lesdits composés étant utiles en médecine, y compris en tant qu'excipients pharmaceutiques, adhésifs et matériaux filmogènes et/ou étant utiles dans le traitement d'affections caractérisées par une inflammation, notamment des plaies, des brûlures et des troubles de la muqueuse tels que des maladies anorectales, des maladies intestinales inflammatoires, des maladies gynécologiques et des maladies dentaires.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title NEW MULTI-FUNCTIONAL OLIGOPEPTIDES
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