COMPOSITIONS AND METHODS FOR INHIBITION OF RAS
Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic fonns, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation)...
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| creator | XU, Rui YANG, Yue ZHANG, Zuhui WALLACE, Eli LIGHTSTONE, Felice LIAO, Tao PEI, Jun BRASSARD, Christopher John CHAN, Albert Hay Wah WANG, Bin MACIAG, Anna Elzbieta TURNER, David Michael SIMANSHU, Dhirendra Kumar |
| description | Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic fonns, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
L'invention concerne des composés, ou des sels, des esters, des tautomères, des promédicaments, des formes zwitterioniques, ou des stéréoisomères de ceux-ci, ainsi que des compositions pharmaceutiques les comprenant. L'invention concerne également des procédés d'utilisation de ceux-ci dans la modulation (par exemple, l'inhibition) de KRAS (par exemple, KRAS ayant une mutation G12C) et le traitement de maladies ou de troubles tels que des cancers chez des sujets en ayant besoin. |
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L'invention concerne des composés, ou des sels, des esters, des tautomères, des promédicaments, des formes zwitterioniques, ou des stéréoisomères de ceux-ci, ainsi que des compositions pharmaceutiques les comprenant. L'invention concerne également des procédés d'utilisation de ceux-ci dans la modulation (par exemple, l'inhibition) de KRAS (par exemple, KRAS ayant une mutation G12C) et le traitement de maladies ou de troubles tels que des cancers chez des sujets en ayant besoin.</abstract><oa>free_for_read</oa></addata></record> |
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| title | COMPOSITIONS AND METHODS FOR INHIBITION OF RAS |
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