BIFUNCTIONAL COMPOUNDS FOR DEGRADING KRAS G12D VIA UBIQUITIN PROTEASOME PATHWAY
Disclosed herein are certain bifunctional compounds that cause degradation of K-ras G12D via ubiquitin proteasome pathway and are therefore useful for the treatment of diseases mediated by K-ras G12D, pharmaceutical compositions containing such compounds and processes for preparing such compounds. L...
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| creator | FU, Jiping SUN, Yongfeng ZENG, Haiqiang |
| description | Disclosed herein are certain bifunctional compounds that cause degradation of K-ras G12D via ubiquitin proteasome pathway and are therefore useful for the treatment of diseases mediated by K-ras G12D, pharmaceutical compositions containing such compounds and processes for preparing such compounds.
L'invention concerne certains composés bifonctionnels qui provoquent la dégradation de K-ras G12D par l'intermédiaire de la voie ubiquitine-protéasome et sont par conséquent utiles pour le traitement de maladies médiées par K-ras G12D, des compositions pharmaceutiques contenant de tels composés et des procédés de préparation de tels composés. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BIFUNCTIONAL COMPOUNDS FOR DEGRADING KRAS G12D VIA UBIQUITIN PROTEASOME PATHWAY |
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