COMPOUND, PREPARATION METHOD, AND LIPID NANOPARTICLES AND PHARMACEUTICAL COMPOSITION THEREOF

The present invention provides a compound, a preparation method, and lipid nanoparticles and a pharmaceutical composition thereof. The compound comprises: at least one structural general formula of formula (I-1), or the compound as a pharmaceutically acceptable salt, prodrug, or isomer thereof. The compound of the present invention increases structural variety, thereby increasing the structural variety of lipid molecules. The structure of the compound directly provides biodegradability. The L1a, L1b and L1c of the compound can be exchanged as desired with L2, allowing the compound to directly accommodate other types of molecules, such as steroids, peptides, etc., so as to perform direct and rapid screening, thereby allowing for expanding the functionality of a cationic lipid compound itself, allowing for functional molecules to be directly coupled to the cationic lipid compound, thus having the effect of directly expanding functionality. The ease of substitution of the L structure of the compound enables the