NOVEL RNA THERAPEUTICS AND USES THEREOF
The present invention relates to novel therapeutic compounds, known as RNAi agents, that decrease expression of the ANGPTL8 receptor (expressed by the ANGPTL8 gene), thereby decreasing expression of mRNA and protein expression. Such RNAi agents are useful in the treatment of diseases involving the r...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | BEYER, Thomas Patrick CHENG, Christine Chih-Tao EGGEN, Marijean WILSON, Takako ANTONELLIS, Patrick Joseph MILES, Rebecca Ruth BAWEL, Seth Andrew WANG, Jibo LACKNER, Gregory Lawrence |
| description | The present invention relates to novel therapeutic compounds, known as RNAi agents, that decrease expression of the ANGPTL8 receptor (expressed by the ANGPTL8 gene), thereby decreasing expression of mRNA and protein expression. Such RNAi agents are useful in the treatment of diseases involving the regulation of ANGPTL8 expression and function, such as dyslipidemia, a cardiovascular disorder, or a cardiometabolic disorder.
La présente invention concerne de nouveaux composés thérapeutiques, connus sous le nom d'agents ARNi, qui diminuent l'expression du récepteur ANGPTL8 (exprimé par le gène ANGPTL8), diminuant ainsi l'expression de l'ARNm et l'expression protéique. De tels agents ARNi sont utiles dans le traitement de maladies impliquant la régulation de l'expression et de la fonction d'ANGPTL8, telles que la dyslipidémie, le trouble cardiovasculaire ou le trouble cardiométabolique. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2024138111A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2024138111A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2024138111A13</originalsourceid><addsrcrecordid>eNrjZFD38w9z9VEI8nNUCPFwDXIMcA0N8XQOVnD0c1EIDXYNBou6-rvxMLCmJeYUp_JCaW4GZTfXEGcP3dSC_PjU4oLE5NS81JL4cH8jAyMTQ2MLQ0NDR0Nj4lQBAG9oJKI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NOVEL RNA THERAPEUTICS AND USES THEREOF</title><source>esp@cenet</source><creator>BEYER, Thomas Patrick ; CHENG, Christine Chih-Tao ; EGGEN, Marijean ; WILSON, Takako ; ANTONELLIS, Patrick Joseph ; MILES, Rebecca Ruth ; BAWEL, Seth Andrew ; WANG, Jibo ; LACKNER, Gregory Lawrence</creator><creatorcontrib>BEYER, Thomas Patrick ; CHENG, Christine Chih-Tao ; EGGEN, Marijean ; WILSON, Takako ; ANTONELLIS, Patrick Joseph ; MILES, Rebecca Ruth ; BAWEL, Seth Andrew ; WANG, Jibo ; LACKNER, Gregory Lawrence</creatorcontrib><description>The present invention relates to novel therapeutic compounds, known as RNAi agents, that decrease expression of the ANGPTL8 receptor (expressed by the ANGPTL8 gene), thereby decreasing expression of mRNA and protein expression. Such RNAi agents are useful in the treatment of diseases involving the regulation of ANGPTL8 expression and function, such as dyslipidemia, a cardiovascular disorder, or a cardiometabolic disorder.
La présente invention concerne de nouveaux composés thérapeutiques, connus sous le nom d'agents ARNi, qui diminuent l'expression du récepteur ANGPTL8 (exprimé par le gène ANGPTL8), diminuant ainsi l'expression de l'ARNm et l'expression protéique. De tels agents ARNi sont utiles dans le traitement de maladies impliquant la régulation de l'expression et de la fonction d'ANGPTL8, telles que la dyslipidémie, le trouble cardiovasculaire ou le trouble cardiométabolique.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240627&DB=EPODOC&CC=WO&NR=2024138111A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240627&DB=EPODOC&CC=WO&NR=2024138111A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BEYER, Thomas Patrick</creatorcontrib><creatorcontrib>CHENG, Christine Chih-Tao</creatorcontrib><creatorcontrib>EGGEN, Marijean</creatorcontrib><creatorcontrib>WILSON, Takako</creatorcontrib><creatorcontrib>ANTONELLIS, Patrick Joseph</creatorcontrib><creatorcontrib>MILES, Rebecca Ruth</creatorcontrib><creatorcontrib>BAWEL, Seth Andrew</creatorcontrib><creatorcontrib>WANG, Jibo</creatorcontrib><creatorcontrib>LACKNER, Gregory Lawrence</creatorcontrib><title>NOVEL RNA THERAPEUTICS AND USES THEREOF</title><description>The present invention relates to novel therapeutic compounds, known as RNAi agents, that decrease expression of the ANGPTL8 receptor (expressed by the ANGPTL8 gene), thereby decreasing expression of mRNA and protein expression. Such RNAi agents are useful in the treatment of diseases involving the regulation of ANGPTL8 expression and function, such as dyslipidemia, a cardiovascular disorder, or a cardiometabolic disorder.
La présente invention concerne de nouveaux composés thérapeutiques, connus sous le nom d'agents ARNi, qui diminuent l'expression du récepteur ANGPTL8 (exprimé par le gène ANGPTL8), diminuant ainsi l'expression de l'ARNm et l'expression protéique. De tels agents ARNi sont utiles dans le traitement de maladies impliquant la régulation de l'expression et de la fonction d'ANGPTL8, telles que la dyslipidémie, le trouble cardiovasculaire ou le trouble cardiométabolique.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD38w9z9VEI8nNUCPFwDXIMcA0N8XQOVnD0c1EIDXYNBou6-rvxMLCmJeYUp_JCaW4GZTfXEGcP3dSC_PjU4oLE5NS81JL4cH8jAyMTQ2MLQ0NDR0Nj4lQBAG9oJKI</recordid><startdate>20240627</startdate><enddate>20240627</enddate><creator>BEYER, Thomas Patrick</creator><creator>CHENG, Christine Chih-Tao</creator><creator>EGGEN, Marijean</creator><creator>WILSON, Takako</creator><creator>ANTONELLIS, Patrick Joseph</creator><creator>MILES, Rebecca Ruth</creator><creator>BAWEL, Seth Andrew</creator><creator>WANG, Jibo</creator><creator>LACKNER, Gregory Lawrence</creator><scope>EVB</scope></search><sort><creationdate>20240627</creationdate><title>NOVEL RNA THERAPEUTICS AND USES THEREOF</title><author>BEYER, Thomas Patrick ; CHENG, Christine Chih-Tao ; EGGEN, Marijean ; WILSON, Takako ; ANTONELLIS, Patrick Joseph ; MILES, Rebecca Ruth ; BAWEL, Seth Andrew ; WANG, Jibo ; LACKNER, Gregory Lawrence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024138111A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>BEYER, Thomas Patrick</creatorcontrib><creatorcontrib>CHENG, Christine Chih-Tao</creatorcontrib><creatorcontrib>EGGEN, Marijean</creatorcontrib><creatorcontrib>WILSON, Takako</creatorcontrib><creatorcontrib>ANTONELLIS, Patrick Joseph</creatorcontrib><creatorcontrib>MILES, Rebecca Ruth</creatorcontrib><creatorcontrib>BAWEL, Seth Andrew</creatorcontrib><creatorcontrib>WANG, Jibo</creatorcontrib><creatorcontrib>LACKNER, Gregory Lawrence</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BEYER, Thomas Patrick</au><au>CHENG, Christine Chih-Tao</au><au>EGGEN, Marijean</au><au>WILSON, Takako</au><au>ANTONELLIS, Patrick Joseph</au><au>MILES, Rebecca Ruth</au><au>BAWEL, Seth Andrew</au><au>WANG, Jibo</au><au>LACKNER, Gregory Lawrence</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL RNA THERAPEUTICS AND USES THEREOF</title><date>2024-06-27</date><risdate>2024</risdate><abstract>The present invention relates to novel therapeutic compounds, known as RNAi agents, that decrease expression of the ANGPTL8 receptor (expressed by the ANGPTL8 gene), thereby decreasing expression of mRNA and protein expression. Such RNAi agents are useful in the treatment of diseases involving the regulation of ANGPTL8 expression and function, such as dyslipidemia, a cardiovascular disorder, or a cardiometabolic disorder.
La présente invention concerne de nouveaux composés thérapeutiques, connus sous le nom d'agents ARNi, qui diminuent l'expression du récepteur ANGPTL8 (exprimé par le gène ANGPTL8), diminuant ainsi l'expression de l'ARNm et l'expression protéique. De tels agents ARNi sont utiles dans le traitement de maladies impliquant la régulation de l'expression et de la fonction d'ANGPTL8, telles que la dyslipidémie, le trouble cardiovasculaire ou le trouble cardiométabolique.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2024138111A1 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | NOVEL RNA THERAPEUTICS AND USES THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T17%3A40%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=BEYER,%20Thomas%20Patrick&rft.date=2024-06-27&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2024138111A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |