CD3 AND ITCR EXPRESSING ENGINEERED NATURAL KILLER CELLS WITH ENHANCED FUNCTION FOR ADOPTIVE IMMUNOTHERAPY
Embodiments of the disclosure include methods and compositions in which NK cells are modified by the hand of man to express the invariant NK T-cell receptor and CD3 co-receptor on NK cells that do not naturally express them. Such modified NK cells work effectively with bispecific or multi-specific a...
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creator | MARIN COSTA, David REZVANI, Katy BASAR, Rafet LIU, Bin |
description | Embodiments of the disclosure include methods and compositions in which NK cells are modified by the hand of man to express the invariant NK T-cell receptor and CD3 co-receptor on NK cells that do not naturally express them. Such modified NK cells work effectively with bispecific or multi-specific antibodies that are tailored to comprise anti-CD3 antibodies that bind the modified NK cells, thereby triggering signaling, activation, and cytotoxicity of target cells to which the antibodies also bind. Thus, the NK cells are specifically configured to be able to work effectively with Bispecific NK cell engagers (BiKEs) as well as Bispecific T cell Engagers (BiTEs).
Des modes de réalisation de la divulgation comprennent des méthodes et des compositions dans lesquelles des cellules NK sont modifiées par la main de l'homme pour exprimer le récepteur des lymphocytes T NK et le co-récepteur CD3 sur des cellules NK qui ne les expriment pas naturellement. De telles cellules NK modifiées fonctionnent efficacement avec des anticorps bispécifiques ou multi-spécifiques qui sont adaptés pour comprendre des anticorps anti-CD3 qui se lient aux cellules NK modifiées, ce qui permet de déclencher la signalisation, l'activation et la cytotoxicité de cellules cibles auxquelles les anticorps se lient également. Ainsi, les cellules NK sont spécifiquement conçues pour pouvoir fonctionner efficacement avec des engageurs de cellules NK bispécifiques (BiKE) ainsi que des engageurs de lymphocytes T bispécifiques (BiTE). |
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Des modes de réalisation de la divulgation comprennent des méthodes et des compositions dans lesquelles des cellules NK sont modifiées par la main de l'homme pour exprimer le récepteur des lymphocytes T NK et le co-récepteur CD3 sur des cellules NK qui ne les expriment pas naturellement. De telles cellules NK modifiées fonctionnent efficacement avec des anticorps bispécifiques ou multi-spécifiques qui sont adaptés pour comprendre des anticorps anti-CD3 qui se lient aux cellules NK modifiées, ce qui permet de déclencher la signalisation, l'activation et la cytotoxicité de cellules cibles auxquelles les anticorps se lient également. Ainsi, les cellules NK sont spécifiquement conçues pour pouvoir fonctionner efficacement avec des engageurs de cellules NK bispécifiques (BiKE) ainsi que des engageurs de lymphocytes T bispécifiques (BiTE).</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240829&DB=EPODOC&CC=WO&NR=2024137789A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240829&DB=EPODOC&CC=WO&NR=2024137789A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MARIN COSTA, David</creatorcontrib><creatorcontrib>REZVANI, Katy</creatorcontrib><creatorcontrib>BASAR, Rafet</creatorcontrib><creatorcontrib>LIU, Bin</creatorcontrib><title>CD3 AND ITCR EXPRESSING ENGINEERED NATURAL KILLER CELLS WITH ENHANCED FUNCTION FOR ADOPTIVE IMMUNOTHERAPY</title><description>Embodiments of the disclosure include methods and compositions in which NK cells are modified by the hand of man to express the invariant NK T-cell receptor and CD3 co-receptor on NK cells that do not naturally express them. Such modified NK cells work effectively with bispecific or multi-specific antibodies that are tailored to comprise anti-CD3 antibodies that bind the modified NK cells, thereby triggering signaling, activation, and cytotoxicity of target cells to which the antibodies also bind. Thus, the NK cells are specifically configured to be able to work effectively with Bispecific NK cell engagers (BiKEs) as well as Bispecific T cell Engagers (BiTEs).
Des modes de réalisation de la divulgation comprennent des méthodes et des compositions dans lesquelles des cellules NK sont modifiées par la main de l'homme pour exprimer le récepteur des lymphocytes T NK et le co-récepteur CD3 sur des cellules NK qui ne les expriment pas naturellement. De telles cellules NK modifiées fonctionnent efficacement avec des anticorps bispécifiques ou multi-spécifiques qui sont adaptés pour comprendre des anticorps anti-CD3 qui se lient aux cellules NK modifiées, ce qui permet de déclencher la signalisation, l'activation et la cytotoxicité de cellules cibles auxquelles les anticorps se lient également. Ainsi, les cellules NK sont spécifiquement conçues pour pouvoir fonctionner efficacement avec des engageurs de cellules NK bispécifiques (BiKE) ainsi que des engageurs de lymphocytes T bispécifiques (BiTE).</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQANAuDqL-w4GzoI1QHUNybQ7TS0lTq1MpEkEQLdT_xw5-gNNb3jx5KC1AsgYKygNeKo91TVwAckGM6FEDy9B4aeFE1qIHhdbW0FIwUzKS1VTyhlUgx5A7D1K7KtAZgcqyYRcMelldl8ns3j_HuPq5SNY5BmU2cXh3cRz6W3zFT9e6dJvudyLLDkcpxH_rCxplNvE</recordid><startdate>20240829</startdate><enddate>20240829</enddate><creator>MARIN COSTA, David</creator><creator>REZVANI, Katy</creator><creator>BASAR, Rafet</creator><creator>LIU, Bin</creator><scope>EVB</scope></search><sort><creationdate>20240829</creationdate><title>CD3 AND ITCR EXPRESSING ENGINEERED NATURAL KILLER CELLS WITH ENHANCED FUNCTION FOR ADOPTIVE IMMUNOTHERAPY</title><author>MARIN COSTA, David ; REZVANI, Katy ; BASAR, Rafet ; LIU, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024137789A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MARIN COSTA, David</creatorcontrib><creatorcontrib>REZVANI, Katy</creatorcontrib><creatorcontrib>BASAR, Rafet</creatorcontrib><creatorcontrib>LIU, Bin</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MARIN COSTA, David</au><au>REZVANI, Katy</au><au>BASAR, Rafet</au><au>LIU, Bin</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CD3 AND ITCR EXPRESSING ENGINEERED NATURAL KILLER CELLS WITH ENHANCED FUNCTION FOR ADOPTIVE IMMUNOTHERAPY</title><date>2024-08-29</date><risdate>2024</risdate><abstract>Embodiments of the disclosure include methods and compositions in which NK cells are modified by the hand of man to express the invariant NK T-cell receptor and CD3 co-receptor on NK cells that do not naturally express them. Such modified NK cells work effectively with bispecific or multi-specific antibodies that are tailored to comprise anti-CD3 antibodies that bind the modified NK cells, thereby triggering signaling, activation, and cytotoxicity of target cells to which the antibodies also bind. Thus, the NK cells are specifically configured to be able to work effectively with Bispecific NK cell engagers (BiKEs) as well as Bispecific T cell Engagers (BiTEs).
Des modes de réalisation de la divulgation comprennent des méthodes et des compositions dans lesquelles des cellules NK sont modifiées par la main de l'homme pour exprimer le récepteur des lymphocytes T NK et le co-récepteur CD3 sur des cellules NK qui ne les expriment pas naturellement. De telles cellules NK modifiées fonctionnent efficacement avec des anticorps bispécifiques ou multi-spécifiques qui sont adaptés pour comprendre des anticorps anti-CD3 qui se lient aux cellules NK modifiées, ce qui permet de déclencher la signalisation, l'activation et la cytotoxicité de cellules cibles auxquelles les anticorps se lient également. Ainsi, les cellules NK sont spécifiquement conçues pour pouvoir fonctionner efficacement avec des engageurs de cellules NK bispécifiques (BiKE) ainsi que des engageurs de lymphocytes T bispécifiques (BiTE).</abstract><oa>free_for_read</oa></addata></record> |
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subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
title | CD3 AND ITCR EXPRESSING ENGINEERED NATURAL KILLER CELLS WITH ENHANCED FUNCTION FOR ADOPTIVE IMMUNOTHERAPY |
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