P2X3 RECEPTOR ANTAGONISTS
This invention relates to compounds of formula (I) and their use as antagonists of P2X3 and P2X2/3 receptor activity, pharmaceutical compositions comprising such compounds, and methods oftreatment therewith. Compounds ofthe invention can be used for the treatment and/or prevention of pain and cluoni...
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| creator | RIVA, Carlo FRIGERIO, Fabio TAZZARI, Valerio GRAZIANI, Davide MENEGON, Sergio PIRONA, Lorenza |
| description | This invention relates to compounds of formula (I) and their use as antagonists of P2X3 and P2X2/3 receptor activity, pharmaceutical compositions comprising such compounds, and methods oftreatment therewith. Compounds ofthe invention can be used for the treatment and/or prevention of pain and cluonic pain and tolerance to analgesic, respiratory disorders and dysfunctions, and treatment of overactive bladder, bladder pain syndrome, dysuria and in general in genitourinary diseases, cardiovascular disorders and more in general for the potential treatment of visceral organ diseases and disorders charucteized by the involvement of P2X3 and P2X2/3 receptors.
La présente invention concerne des composés de formule (I) et leur utilisation en tant qu'antagonistes de l'activité des récepteurs P2X3 et P2X2/3, des compositions pharmaceutiques comprenant de tels composés, et des méthodes de traitement les utilisant. Les composés selon l'invention peuvent être utilisés pour traiter et/ou prévenir la douleur, la douleur chronique, l'accoutumance aux analgésiques, des troubles et dysfonctionnements respiratoires, et pour traiter la vessie hyperactive, la cystite interstitielle, la dysurie et d'une manière générale des maladies génito-urinaires, des troubles cardiovasculaires et plus particulièrement pour le traitement potentiel de maladies et de troubles des organes viscéraux caractérisés par l'implication des récepteurs P2X3 et P2X2/3. |
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La présente invention concerne des composés de formule (I) et leur utilisation en tant qu'antagonistes de l'activité des récepteurs P2X3 et P2X2/3, des compositions pharmaceutiques comprenant de tels composés, et des méthodes de traitement les utilisant. Les composés selon l'invention peuvent être utilisés pour traiter et/ou prévenir la douleur, la douleur chronique, l'accoutumance aux analgésiques, des troubles et dysfonctionnements respiratoires, et pour traiter la vessie hyperactive, la cystite interstitielle, la dysurie et d'une manière générale des maladies génito-urinaires, des troubles cardiovasculaires et plus particulièrement pour le traitement potentiel de maladies et de troubles des organes viscéraux caractérisés par l'implication des récepteurs P2X3 et P2X2/3.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240802&DB=EPODOC&CC=WO&NR=2024133200A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240802&DB=EPODOC&CC=WO&NR=2024133200A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RIVA, Carlo</creatorcontrib><creatorcontrib>FRIGERIO, Fabio</creatorcontrib><creatorcontrib>TAZZARI, Valerio</creatorcontrib><creatorcontrib>GRAZIANI, Davide</creatorcontrib><creatorcontrib>MENEGON, Sergio</creatorcontrib><creatorcontrib>PIRONA, Lorenza</creatorcontrib><title>P2X3 RECEPTOR ANTAGONISTS</title><description>This invention relates to compounds of formula (I) and their use as antagonists of P2X3 and P2X2/3 receptor activity, pharmaceutical compositions comprising such compounds, and methods oftreatment therewith. Compounds ofthe invention can be used for the treatment and/or prevention of pain and cluonic pain and tolerance to analgesic, respiratory disorders and dysfunctions, and treatment of overactive bladder, bladder pain syndrome, dysuria and in general in genitourinary diseases, cardiovascular disorders and more in general for the potential treatment of visceral organ diseases and disorders charucteized by the involvement of P2X3 and P2X2/3 receptors.
La présente invention concerne des composés de formule (I) et leur utilisation en tant qu'antagonistes de l'activité des récepteurs P2X3 et P2X2/3, des compositions pharmaceutiques comprenant de tels composés, et des méthodes de traitement les utilisant. Les composés selon l'invention peuvent être utilisés pour traiter et/ou prévenir la douleur, la douleur chronique, l'accoutumance aux analgésiques, des troubles et dysfonctionnements respiratoires, et pour traiter la vessie hyperactive, la cystite interstitielle, la dysurie et d'une manière générale des maladies génito-urinaires, des troubles cardiovasculaires et plus particulièrement pour le traitement potentiel de maladies et de troubles des organes viscéraux caractérisés par l'implication des récepteurs P2X3 et P2X2/3.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJAMMIowVghydXYNCPEPUnD0C3F09_fzDA4J5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgZGJobGxkYGBo4mxsSpAgCPVyDU</recordid><startdate>20240802</startdate><enddate>20240802</enddate><creator>RIVA, Carlo</creator><creator>FRIGERIO, Fabio</creator><creator>TAZZARI, Valerio</creator><creator>GRAZIANI, Davide</creator><creator>MENEGON, Sergio</creator><creator>PIRONA, Lorenza</creator><scope>EVB</scope></search><sort><creationdate>20240802</creationdate><title>P2X3 RECEPTOR ANTAGONISTS</title><author>RIVA, Carlo ; FRIGERIO, Fabio ; TAZZARI, Valerio ; GRAZIANI, Davide ; MENEGON, Sergio ; PIRONA, Lorenza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024133200A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RIVA, Carlo</creatorcontrib><creatorcontrib>FRIGERIO, Fabio</creatorcontrib><creatorcontrib>TAZZARI, Valerio</creatorcontrib><creatorcontrib>GRAZIANI, Davide</creatorcontrib><creatorcontrib>MENEGON, Sergio</creatorcontrib><creatorcontrib>PIRONA, Lorenza</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RIVA, Carlo</au><au>FRIGERIO, Fabio</au><au>TAZZARI, Valerio</au><au>GRAZIANI, Davide</au><au>MENEGON, Sergio</au><au>PIRONA, Lorenza</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>P2X3 RECEPTOR ANTAGONISTS</title><date>2024-08-02</date><risdate>2024</risdate><abstract>This invention relates to compounds of formula (I) and their use as antagonists of P2X3 and P2X2/3 receptor activity, pharmaceutical compositions comprising such compounds, and methods oftreatment therewith. Compounds ofthe invention can be used for the treatment and/or prevention of pain and cluonic pain and tolerance to analgesic, respiratory disorders and dysfunctions, and treatment of overactive bladder, bladder pain syndrome, dysuria and in general in genitourinary diseases, cardiovascular disorders and more in general for the potential treatment of visceral organ diseases and disorders charucteized by the involvement of P2X3 and P2X2/3 receptors.
La présente invention concerne des composés de formule (I) et leur utilisation en tant qu'antagonistes de l'activité des récepteurs P2X3 et P2X2/3, des compositions pharmaceutiques comprenant de tels composés, et des méthodes de traitement les utilisant. Les composés selon l'invention peuvent être utilisés pour traiter et/ou prévenir la douleur, la douleur chronique, l'accoutumance aux analgésiques, des troubles et dysfonctionnements respiratoires, et pour traiter la vessie hyperactive, la cystite interstitielle, la dysurie et d'une manière générale des maladies génito-urinaires, des troubles cardiovasculaires et plus particulièrement pour le traitement potentiel de maladies et de troubles des organes viscéraux caractérisés par l'implication des récepteurs P2X3 et P2X2/3.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | P2X3 RECEPTOR ANTAGONISTS |
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