IMMUNOGENIC COMPOSITIONS AND METHODS FOR ELICITING AN IMMUNE RESPONSE AGAINST CLOSTRIDIOIDES (CLOSTRIDIUM) DIFFICILE
The present invention relates to immunogenic compositions that comprise a Clostridioides difficile toxoid A and/or a C. difficile toxoid B, and an adjuvant, and methods of use thereof. The present invention further relate to a methods for eliciting an enhanced immune response in a human against a C....
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| creator | ANDERSON, Annaliesa Sybil SHI, Shuai GONZALEZ-GARIS, Marina A SURENDRAN, Naveen HU, Lei KANEVSKY, Isis LIBERATOR, Paul Arthur MORAN, Justin Keith PHELAN, Lynn Marie PRIDE, Michael William |
| description | The present invention relates to immunogenic compositions that comprise a Clostridioides difficile toxoid A and/or a C. difficile toxoid B, and an adjuvant, and methods of use thereof. The present invention further relate to a methods for eliciting an enhanced immune response in a human against a C. difficile infection. The methods include administering to the human an effective dose of an immunogenic composition, which includes a C. difficile toxoid and an adjuvant, wherein the composition is administered two times.
La présente invention concerne des compositions immunogènes qui comprennent un toxoïde de Clostridioides difficile A et/ou un toxoïde de C. difficile B, et un adjuvant, et leurs procédés d'utilisation. La présente invention concerne en outre des procédés pour déclencher une réponse immunitaire améliorée chez un être humain contre une infection par C. difficile. Les procédés comprennent l'administration à l'être humain d'une dose efficace d'une composition immunogène, qui comprend un toxoïde de C. difficile et un adjuvant, la composition étant administrée deux fois. |
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La présente invention concerne des compositions immunogènes qui comprennent un toxoïde de Clostridioides difficile A et/ou un toxoïde de C. difficile B, et un adjuvant, et leurs procédés d'utilisation. La présente invention concerne en outre des procédés pour déclencher une réponse immunitaire améliorée chez un être humain contre une infection par C. difficile. Les procédés comprennent l'administration à l'être humain d'une dose efficace d'une composition immunogène, qui comprend un toxoïde de C. difficile et un adjuvant, la composition étant administrée deux fois.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240620&DB=EPODOC&CC=WO&NR=2024127215A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240620&DB=EPODOC&CC=WO&NR=2024127215A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ANDERSON, Annaliesa Sybil</creatorcontrib><creatorcontrib>SHI, Shuai</creatorcontrib><creatorcontrib>GONZALEZ-GARIS, Marina A</creatorcontrib><creatorcontrib>SURENDRAN, Naveen</creatorcontrib><creatorcontrib>HU, Lei</creatorcontrib><creatorcontrib>KANEVSKY, Isis</creatorcontrib><creatorcontrib>LIBERATOR, Paul Arthur</creatorcontrib><creatorcontrib>MORAN, Justin Keith</creatorcontrib><creatorcontrib>PHELAN, Lynn Marie</creatorcontrib><creatorcontrib>PRIDE, Michael William</creatorcontrib><title>IMMUNOGENIC COMPOSITIONS AND METHODS FOR ELICITING AN IMMUNE RESPONSE AGAINST CLOSTRIDIOIDES (CLOSTRIDIUM) DIFFICILE</title><description>The present invention relates to immunogenic compositions that comprise a Clostridioides difficile toxoid A and/or a C. difficile toxoid B, and an adjuvant, and methods of use thereof. The present invention further relate to a methods for eliciting an enhanced immune response in a human against a C. difficile infection. The methods include administering to the human an effective dose of an immunogenic composition, which includes a C. difficile toxoid and an adjuvant, wherein the composition is administered two times.
La présente invention concerne des compositions immunogènes qui comprennent un toxoïde de Clostridioides difficile A et/ou un toxoïde de C. difficile B, et un adjuvant, et leurs procédés d'utilisation. La présente invention concerne en outre des procédés pour déclencher une réponse immunitaire améliorée chez un être humain contre une infection par C. difficile. Les procédés comprennent l'administration à l'être humain d'une dose efficace d'une composition immunogène, qui comprend un toxoïde de C. difficile et un adjuvant, la composition étant administrée deux fois.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEKwjAURbs4iPoPD1x0EGysOIfkpX3Q5JUmxbEUiZNoof1_DCLOTpfLOfcus5ms7RyX6EiBYtuwp0DsPEinwWKoWHsw3ALWpBJyZSLwWSG06JvkIshSkvMBVM0-tKSJSaOH3a93dg-ajEkfNa6zxX14THHzzVW2NRhUdYjjq4_TONziM879lcVRFLm4iPwsxek_6w3RzjoZ</recordid><startdate>20240620</startdate><enddate>20240620</enddate><creator>ANDERSON, Annaliesa Sybil</creator><creator>SHI, Shuai</creator><creator>GONZALEZ-GARIS, Marina A</creator><creator>SURENDRAN, Naveen</creator><creator>HU, Lei</creator><creator>KANEVSKY, Isis</creator><creator>LIBERATOR, Paul Arthur</creator><creator>MORAN, Justin Keith</creator><creator>PHELAN, Lynn Marie</creator><creator>PRIDE, Michael William</creator><scope>EVB</scope></search><sort><creationdate>20240620</creationdate><title>IMMUNOGENIC COMPOSITIONS AND METHODS FOR ELICITING AN IMMUNE RESPONSE AGAINST CLOSTRIDIOIDES (CLOSTRIDIUM) DIFFICILE</title><author>ANDERSON, Annaliesa Sybil ; SHI, Shuai ; GONZALEZ-GARIS, Marina A ; SURENDRAN, Naveen ; HU, Lei ; KANEVSKY, Isis ; LIBERATOR, Paul Arthur ; MORAN, Justin Keith ; PHELAN, Lynn Marie ; PRIDE, Michael William</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024127215A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ANDERSON, Annaliesa Sybil</creatorcontrib><creatorcontrib>SHI, Shuai</creatorcontrib><creatorcontrib>GONZALEZ-GARIS, Marina A</creatorcontrib><creatorcontrib>SURENDRAN, Naveen</creatorcontrib><creatorcontrib>HU, Lei</creatorcontrib><creatorcontrib>KANEVSKY, Isis</creatorcontrib><creatorcontrib>LIBERATOR, Paul Arthur</creatorcontrib><creatorcontrib>MORAN, Justin Keith</creatorcontrib><creatorcontrib>PHELAN, Lynn Marie</creatorcontrib><creatorcontrib>PRIDE, Michael William</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ANDERSON, Annaliesa Sybil</au><au>SHI, Shuai</au><au>GONZALEZ-GARIS, Marina A</au><au>SURENDRAN, Naveen</au><au>HU, Lei</au><au>KANEVSKY, Isis</au><au>LIBERATOR, Paul Arthur</au><au>MORAN, Justin Keith</au><au>PHELAN, Lynn Marie</au><au>PRIDE, Michael William</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IMMUNOGENIC COMPOSITIONS AND METHODS FOR ELICITING AN IMMUNE RESPONSE AGAINST CLOSTRIDIOIDES (CLOSTRIDIUM) DIFFICILE</title><date>2024-06-20</date><risdate>2024</risdate><abstract>The present invention relates to immunogenic compositions that comprise a Clostridioides difficile toxoid A and/or a C. difficile toxoid B, and an adjuvant, and methods of use thereof. The present invention further relate to a methods for eliciting an enhanced immune response in a human against a C. difficile infection. The methods include administering to the human an effective dose of an immunogenic composition, which includes a C. difficile toxoid and an adjuvant, wherein the composition is administered two times.
La présente invention concerne des compositions immunogènes qui comprennent un toxoïde de Clostridioides difficile A et/ou un toxoïde de C. difficile B, et un adjuvant, et leurs procédés d'utilisation. La présente invention concerne en outre des procédés pour déclencher une réponse immunitaire améliorée chez un être humain contre une infection par C. difficile. Les procédés comprennent l'administration à l'être humain d'une dose efficace d'une composition immunogène, qui comprend un toxoïde de C. difficile et un adjuvant, la composition étant administrée deux fois.</abstract><oa>free_for_read</oa></addata></record> |
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| title | IMMUNOGENIC COMPOSITIONS AND METHODS FOR ELICITING AN IMMUNE RESPONSE AGAINST CLOSTRIDIOIDES (CLOSTRIDIUM) DIFFICILE |
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